Table of CD Markers Practical Class 1 Exercise 1 PDF

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Summary

table on CD markers ...

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Table of CD Markers CD Marker

Ligands T-cell

B-cell

Cell Types Dendritic Monocyte Cell Macrophag e no

Function Granulocyt e

CD3

TCR

yes

no

CD4

MHC II, gp 120, IL-16, Lck

yes

no

Yes

yes

CD8

MHC I, Lck

yes

No

no

no

CD11C

iCb3, fibrinogen, ICAM -1,4

yes

yes

yes

yes

CD14

Endotoxin, liposaccharid e (LPS), TLR4, LBP, LY96, TLR2 CD19, CD21, CD225, Leu13, Lyn, Fyn, Vav, P13kinase

no

no

yes

yes

no

yes

yes

no

no

no

no

no

yes

no

Receptor for interleukin-2

CD19

yes

no

A complex of subunits that mediates T cell transduction. Initiates or augments early phase of T cell activation May play an important roll in T cell mediated killing Important for cell – cell interaction during inflammatory responses Mediates the innate immune response to bacterial liposaccharide Assembles with the antigen receptor of b lymphocytes to decrease the threshold for antigen receptor dependent stimulations. Development and differentiation of b cells into plasma cells.

CD20

Lyn, LCK, Fyn, cell surface protein: 2830, 180-200, 50-60 kDa

yes

yes

CD25

IL-2

yes

yes

CD33

Sugar chains containing sialic acid, α2,6- linked Sialic acid

-

-

+

+

+

Cell adhesion, cell-cell signaling, inhibitory receptor, and apoptosis

CD45

p56lck, p59fyn, Src kinases

+

+

+

+

+

Regulator of Tand B-cell antigen receptor

signaling; regulator of cell growth and differentiation CD45RA

p56lck, p59fyn, Src kinases

+

+

+

+

-

CD45 isoform

CD45RB

p56lck, p59fyn, Src kinases

+

+

+

+

+

CD45 isoform

CD56

NCAM-1, Heparin sulfate

+

CD66b

CD66c, e, Src kinases

-

-

CD123

IL-3, CD131

-

-

CD127

IL-7, CD132, fyn, lyn, Jak1, PI3kinase, Lck

+

-

Cell adhesion and neural plasticity +

Cell adhesion, cellular migration, pathogen binding and activation of signaling pathways

+

-

+

A subunit of the IL-3 receptor and plays an important role in hematopoietic progenitor cell growth and differentiation

+

-

– Receptor for IL-7 and thymic stromal lymphopoietin (TSLP). This receptor is important for V(D)J recombination during development

CD326

A homotypic calciumindependent T-cell adhesion molecule

Instructions Using the file “cd_marker_handbook.pdf” complete the above table. In the “Cell Types” columns add a “+” or “-“ to indicate the presence or absence of a specific marker on that cell type....