4. White Blood Cells (Table) PDF

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Summary

IMMUNOLOGY SEROLOGY WHITE BLOOD CELLS WHITE BLOOD CELLS NEUTROPHILS EOSINOPHILS BASOPHILS MAST CELLS MONOCYTES FUNCTION AMOUNT present in Bacterial infections circulates freely for when in tissues, it stays for 5days increases in Allergic reactions Parasitic infections neutralizes Basophil Mast cell...

Description

IMMUNOLOGY & SEROLOGY

WHITE BLOOD CELLS WHITE BLOOD CELLS

NEUTROPHILS

EOSINOPHILS

BASOPHILS

MAST CELLS

MONOCYTES

FUNCTION

AMOUNT

- present in Bacterial infections - circulates freely for 6-10hrs - when in tissues, it stays for 5days

- increases in Allergic reactions & Parasitic infections - neutralizes Basophil & Mast cell products - capable of Phagocytosis but less efficient than Neutrophils because they lack digestive enzymes - increases in Immediate Hypersensitivity reactions - lack Hydrolytic enzymes although Peroxidase is present - life-span: only few hours

50-70%

1-3%

< 1%

- increases in Immediate Hypersensitivity reactions by binding IgE - life-span: 9-18 months

- capable of facilitated Phagocytosis

JOYCE ANN S. MAGSAKAY

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4-10%

SIZE

10-15 um

NUCLEUS

CYTOPLASM

GRANULES

Violet-lilac (take up both stain)

1° granules (Azurophilic): - Myeloperoxidase, Elastase, Proteinase, Lysozyme, Cathepsin G, Defensin 2° granules (Specific): - Collagenase, Lactoferrin, Lysozyme, NADPH oxidase 3° granules: - Gelatinase, Plasminogen activator 1° granules: - Acid phosphatase, Arylsufatase 2° granules (Eosin-Specific): - Major Basic Protein, Eosinophil cationic protein, Eosinophil Peroxidase, Eosinophil-derived neurotoxin

has 2-5 lobes

12-15 um

has 2 lobes eccentrically located

Reddishorange (take up Eosin dye)

10-15 um

Granules obscure the Nucleus

Bluish-purple (take up Methylene blue dye)

- has Histamine, Heparin, Eosinophil Chemotactic factor-A

> Basophils

Granules obscure the Nucleus

Bluish-purple (take up Methylene blue dye)

- has Acid Phosphatase, Alkaline Phosphatase, Protease

Irregularly

- dull grayish

Type 1: (similar to Neutrophils)

12-22

BS MEDICAL LABORATORY SCIENCE

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OLFU VALENZUELA

IMMUNOLOGY & SEROLOGY

WHITE BLOOD CELLS Tissue: Macrophage Connective tissue: Histiocytes Bones: Osteoblasts Liver: Kupffer cells Lungs: Alveolar macrophage Brain: Microglial cells

DENDRITIC CELLS Skin: Langerhan cells Visceral organs: Interstitial Dendritic cells Lymphoid: Interdigitating Dendritic cells

(with the help of Opsonins) - also responsible in Thermoregulation & Wound Healing - stay in peripheral blood for 70hrs.

When in becomes Macrophage: - increase in size (25-80 um) - increase in Endoplasmic Reticulum, Lysosomes, Mitochondria - doesn’t contain peroxidase

um

folded / horseshoeshaped nucleus

blue - has hour-glass appearance due to presence of fine dust-like granules - has digestive vacuoles

- Peroxidase, Acid Phosphatase, Arylsufatase Type 2: - β-glucorinase, lysozyme, & lipase (no ACP)

- most potent Phagocytic cell - capable of Phagocytosis & present T-helper cell - believed to be descendants of Myeloid line - covered with long membranous extensions - resembles nerve cell dendrites

JOYCE ANN S. MAGSAKAY

|

BS MEDICAL LABORATORY SCIENCE

|

OLFU VALENZUELA...