470860929 Pharm Antibiotic Cheat Sheet pdf PDF

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Download 470860929 Pharm Antibiotic Cheat Sheet pdf PDF

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ANTIBIOTIC CHEAT SHEET ANTIBIOTIC MOA Inhibition of cell wall synthesis

Inhibition of nucleic acid synthesis Inhibition of protein synthesis

Cell wall

Disruption of cell membrane function

Cell membrane

DNA

Block pathways and inhibit metabolism

Folic acid

Ribosome

How and Where Various Antibiotics Work Gram Negative

Gram Positive Outer membrane Lipoproteins Peptidoglycan Periplasmic space Cutoplasmic membrane

Lipopolysaccharides

Gram +

Porin

Protein

Gram + and -

Penicillins (Amoxicillin) Gram + (Strep, Syphillis) Disrupts synth of peptidoglycan

Tetracyclines (tetracycline, doxycycline) Broad spectrum (Gram +/-, atypicals) Inhibit protein synth

Sulfonamides (TMP-SMZ) UTIs Inhibit DNA synth

Macrolides (azythromycin, erythromycin) Gram + (URI’s, Strep, Staph) Inhibits protein synth

Cephalosporins Disrupts synth of peptidoglycan 1st gen: Gram + (Keflex) 2nd gen: Gram - > Gram + (Cefzil) 3rd gen: Gram - > Gram + Pseudomonas (cefdinir) 4th gen: Pseudomonas (Cefepime) 5th gen: MRSA (Ceftobiprole)

Carbapenems (meropenem) Broad spectrum Disrupts synth of peptidoglycan

Fluoroquinolones (Ciprofloxacin, Levofloxacin) Broad spectrum Inhibit DNA synth

Metronidazole (Flagyl) Anaerobes, protozoa Disrupts DNA

Lincosamides (clindamycin) Step, Staph Inhibit protein synth

Gram Aminoglycosides (streptomycin, tobramycin, gentamicin) Gram - Psuedomonas - TB Inhibit protein synth

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