5 - Q6 explained PDF

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Q6 explained...

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6) Levinthal’s paradox states that due to the wide variety of protein conformation combinations which can occur for a protein to fold, to take the time to search through the combinations would be too time consuming for a protein to fold. It is paradoxical since the amount of conformations a protein can have which is 10100 and the take it takes a protein to fold is very fast 10-13 sec. This means in order for the protein folding to occur within that fast time frame it suggest that conformation folding occurs randomly. If all the possible conformation confirmations would have undergone sampling it would take approximately 1077 years for a protein to fold. In conclusion, Levinthal’s paradox indicates that folding of protein in not a random process so there should be a pathway which simplifies the folding choices....