91709 Pharmacology 2 - subject outline PDF

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SUBJECT OUTLINE 91709 Pharmacology 2 Course area

UTS: Science

Delivery

Spring 2018; City

Credit points 6cp Requisite(s)

91707 Pharmacology 1 These requisites may not apply to students in certain courses. See access conditions.

Result type

Grade and marks

Attendance: 6hpw

Subject coordinator Pharmacology lecturer and subject coordinator Name: Dr Francis Geronimo Email: [email protected]

Teaching staff Dr Francis Ruel Geronimo ([email protected]) Associate Professor Ken Rodgers ([email protected]) Dr Yiguang Lin ([email protected]) Dr Valery Combes ([email protected]) Professor Graham Nicholson ([email protected]) Dr Eileen McGowan ([email protected]) Dr Lana McClements ([email protected]) Dr Hermily-Lourdes Geronimo ([email protected]) Dr Grethel De Dios ([email protected]) Dr Laura Batmanian ([email protected])

Subject description This subject develops and extends the principles governing drug and xenobiotic action covered in 91707 Pharmacology 1. It is designed to foster a problem-solving approach to pharmacology with particular emphasis on applying molecular pharmacology concepts to pathophysiological problems. The objectives are to further develop the concept of receptors as cellular determinants of drug and xenobiotic action, and to develop the concepts of modulated receptors and ion channels in determining drug action. Selective toxicity in the treatment of microbial, viral and protozoal infections is examined as well as toxicokinetic factors, defense mechanisms, cellular reactivity, receptors and binding sites as determinants of target organ toxicity. The clinical efficacy of the major pharmacology drug classes used in the treatment of cancer, affective and psychotic illnesses, cardiovascular disease, lipid disorders, blood disorders, diabetes, peptic ulcers, nausea and vomiting, and disorders of the respiratory and musculoskeletal systems, are examined. In addition, the abuse of drugs is examined including tobacco, alcohol, CNS stimulants, psychotomimetics and the mechanisms underlying drug dependence, including treatment of drug overdose and antidotal therapy in the context of clinical toxicology. Lectures are complemented by a tutorial program which emphasises the clinical nature of the subject and develops lecture material using a variety of tutorial and case study approaches.

Subject learning objectives (SLOs) 16/07/2018 (Spring 2018)

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Upon successful completion of this subject students should be able to: 1. Compare and contrast the principles of pharmacotherapy of bacterial, viral and protozoal infections. 2. Summarise the qualitative and quantitative aspects of drug addiction (such as psychotomimetics, stimulants, and nicotine), tolerance, and withdrawal, and relate these to the treatment of dependence. 3. Compare and contrast the qualitative and quantitative aspects of drugs, drug classes, and drug toxicity of chemotherapeutic agents for cancer and prevention. 4. Differentiate the pharmacology and therapeutic uses of drugs used in the treatment of psychoses, depression, Parkinson's disease, and Alzheimer's disease. 5. Apply the principles of pharmacotherapy and secondary prevention of cardiovascular disorders such as acute coronary syndromes, heart failure, and hypertension. 6. Explain the different aspects involved in drug development and design, including clinical trials, pharmaceutical timelines, budgets and funding, role of biomarkers in clinical trial end points, and surveillance of adverse effects. 7. Describe the use of monoclonal antibodies as both diagnostic and therapeutic agents. 8. Describe the pharmacology and therapeutic uses of common neuropeptides and of drugs that target peptic ulcer disease, gastric motility, and nausea. 9. Clearly communicate the pharmacology and therapeutic applications of major groups of drugs to an general audience using a range of audio-visual tools.

Course intended learning outcomes (CILOs) This subject also contributes specifically to the development of following course intended learning outcomes: An understanding of the nature, practice and application of the chosen science discipline. (1.0) Encompasses problem solving, critical thinking and analysis attributes and an understanding of the scientific method knowledge acquisition. (2.0) The ability to acquire, develop, employ and integrate a range of technical, practical and professional skills, in appropriate and ethical ways within a professional context, autonomously and collaboratively and across a range of disciplinary and professional areas, e.g. time management skills, personal organisation skills, teamwork skills, computing skills, laboratory skills, data handling, quantitative and graphical literacy skills. (3.0) An awareness of the role of science within a global culture and willingness to contribute actively to the shaping of community views on complex issues where the methods and findings of science are relevant. (5.0) An understanding of the different forms of communication - writing, reading, speaking, listening - including visual and graphical, within science and beyond and the ability to apply these appropriately and effectively for different audiences. (6.0)

Contribution to the development of graduate attributes This subject addresses the following Science Graduate Attributes: Graduate attribute 1. Disciplinary knowledge and its appropriate application During the lecture and tutorial materials, you will learn the pharmacological principles of drugs used to treat cardiovascular disease, mental disorders, nervous system diseases, neoplasms, infectious diseases, and autoimmune diseases. Your understanding of the concepts in this subject will be applied to discussions of the pharmacology and rational use of drugs presented in an assessment task using clinical case scenarios. For the video project, you will learn about new drugs and compare them with existing recommended therapeutic agents. Your comprehension and competency of pharmacology will also be assessed in the final exam. Graduate attribute 2. An Inquiry-oriented approach Using the textbook and the lecture handouts as your guide, you can enhance your learning experience by reading relevant published scientific literature. To support this approach, you are provided with pre-class activities for the tutorials as well as videos and questions prior to the lecture. You will read, evaluate and compare articles from peer-reviewed journals in order to complete the tasks required for the clinical case scenario analysis and the video project. 16/07/2018 (Spring 2018)

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Graduate attribute 3. Professional skills and their appropriate application For this subject, you will need excellent time management and organisational skills in order to complete the assessment tasks on time. To gather information and to coordinate activities from your subject coordinator, peers and other UTS staff, you will exercise professional and ethical behaviour. In the tutorials, you will learn how to approach clinical case scenarios and apply this knowledge when you attempt to complete the assessment task on analysis of clinical case scenarios. Similar skills will be applied when you produce your video project. Graduate attribute 5. Engagement with the needs of society Drugs are an important part of the management of medical conditions in the community. New drugs and new pharmacologic activities of existing drugs are discovered and developed to address new problems with existing diseases, to treat new diseases, or to replace older drugs. For the clinical case scenarios in the pre-class activities and case analyses, you will discuss the recommended drugs for selected medical conditions as well as identify the associated side effects and their management. For the video project, you will prepare a visual presentation about a new drug to educate your viewers about the evidence for the drug’s approved use. Graduate attribute 6. Communication skills Through the assessment tasks in this subject, you will further develop your academic and professional written and verbal communication skills. Through the pre-class activities, clinical case scenario analyses and the video project, you should be able to clearly and effectively convey the pharmacologic concepts of drugs and their application.

Teaching and learning strategies To most efficiently utilise the in-class session time available you are encouraged to always read the relevant preparation material before coming to class. You will find the recommended textbook, the lecture handouts, the pre-class videos and pre-class questions on UTSOnline. Please bring your relevant notes and answers to every tutorial session. You will have time during the session to discuss the content with your peers and make further notes to consolidate your pre-class learning. Subject content will be delivered as interactive lectures which include discussion of cases and questions related to the lecture topics. In preparation for the interactive lectures, view the pre-lecture videos and questions for selected topics in UTSOnline. There will also be a revision session about the completed lectures. Feedback to these questions are available immediately after completion of the revision activity. In addition to the lectures, you will attend tutorial classes three times during the teaching session (see Program). These two-hour tutorials expand, reinforce and supplement theoretical material from lectures through clinical case scenarios. In UTSOnline, you can access the tutorial materials containing the clinical case scenarios. In preparation for the tutorials, you will complete the pre-class activities containing the clinical case scenarios and the accompanying questions that will be covered during the tutorials. These tutorials will cover three major topics: cardiovascular drugs, neuropharmacology, and antimicrobials. During the tutorial sessions, you will participate in the discussion of the answers to the questions with your peers and also receive feedback on your understanding of the cases and pharmacology principles. Discussions will involve analysis of the clinical case scenarios and correlating them with the pharmacology of the drugs. Verbal feedback from your tutor will also be given during these sessions.

Content (topics) Concepts of drug efficacy, side effects, drug-receptor interactions, genetics, agonists, and antagonists at an advanced level relevant to medicine, industry and research Clinical efficacy of the major pharmacology drug classes used in the treatment of: cardiovascular disorders, addiction, upper gastrointestinal disorders, nausea and vomiting, microbial infections, neoplastic disorders, psychiatric conditions (including depression, anxiety, and psychosis) and neurodegenerative conditions (such as Parkinson's and Alzheimer's diseases) New drug indications, drug development, and clinical trial pathways

Program Week/Session

Dates

16/07/2018 (Spring 2018)

Description

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Week 1

23 JUL

Orientation Notes: No tutorial sessions. Tutorials start in Week 4.

Week 2

30 JUL

30 JUL: Neurodegenerative diseases 31 JUL: Antidepressants Notes: No tutorial sessions. Tutorials start in Week 4.

Week 3

06 AUG

06 AUG: Pharmacology of addiction; Stimulants and psychostminulants 07 AUG: Antipsychotics Notes: No tutorial sessions. Tutorials start in Week 4.

Week 4

13 AUG

13 AUG: Antibiotics 14 AUG: Antivirals Notes: Tutorials: Drugs for neurologic diseases and drugs of addiction

Week 5

20 AUG

20 AUG: Antifungals; Antimalarials 21 AUG: Antihypertensive drugs Notes: Tutorials: Drugs for neurologic diseases and drugs of addiction

Week 6

27 AUG

27 AUG: Diuretics; Lipid-lowering drugs 28 AUG: Drugs to treat heart failure Notes: Tutorials: Antimicrobials

Week 7

03 SEP

03 SEP: Drugs to treat acute coronary syndrome; Anticoagulants, antiplatelets, and thrombolytics 04 SEP: Antiarrhythmics Notes: Tutorials: Antimicrobials

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STUVAC

10 SEP

STUVAC Notes: No tutorials

Week 8

17 SEP

17 SEP: Non-steroidal anti-inflammatory drugs; Drugs to treat peptic ulcer disease 18 SEP: Histamine and antihistamines Notes: No tutorials.

Week 9

24 SEP

24 SEP: Cancer chemotherapy 25 SEP: Drugs to treat nausea and vomiting Notes: Tutorials: Formative feedback on video project

Week 10

01 OCT

01 OCT: Drug design and development 02 OCT: Immunosuppresive agents Notes: Tutorials: Formative feedback on video project Submit Assessment Task 3 (Clinical Case Scenario Analysis).

Week 11

08 OCT

08 OCT: Clinical toxicology; Monoclonal antibodies 09 OCT: Uric acid and gout Notes: Tutorials: Drugs to treat cardiovascular diseases

Week 12

15 OCT

15 OCT: Revision 1 16 OCT: Revision 2 Notes: Tutorials: Drugs to treat cardiovascular diseases Submit Assessment Task 2 (Video Project) Complete SparkPlus

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Additional information Lectures: Lectures are scheduled on Mondays 16:00 - 18:00 and Tuesdays 12:00 - 13:00. Tutors In your tutorial sessions you will be working with one tutor throughout the semester. These may be full-time members of the School of Life Sciences or part-time staff with relevant backgrounds and experience in teaching science. You will meet your tutors at the first tutorial session. Queries If you have any queries regarding THE SUBJECT, such as timetable conflicts, lecture notes, etc, please send your email to [email protected]. For help with any aspect of the LECTURE CONTENT, please contact the relevant lecturer. For help with any aspect of the TUTORIAL CONTENT, please see your tutor in the appropriate session. For help on anything that affects your ability to complete the ASSESSMENT TASKS, please send your email to [email protected].

Assessment Assessment task 1: Pre-work activity Intent:

To give you the opportunity to develop your knowledge and test your understanding of the topics on cardiovascular drugs, drugs for neurologic disorders, and antimicrobials. This assessment task contributes to the development of the following graduate attributes: 1. Disciplinary knowledge and its appropriate application 2. An Enquiry-oriented approach 3. Professional skills and their appropriate application 5. Engagement with the needs of Society

Objective(s): This assessment task addresses subject learning objective(s): 1, 2, 3, 4 and 5 This assessment task contributes to the development of course intended learning outcome(s): 1.0, 2.0, 3.0 and 5.0 Type:

Report

Groupwork: Individual Weight:

10%

Task:

You will complete pre-work activities are short tests found in UTSOnline. These contain questions based on clinical case scenarios focusing on the pharmacology and rational use of drugs discussed in the tutorials. You have to complete a pre-work activity before each tutorial block (each block encompasses two weeks; see Program). Each tutorial block will focus on the three major tutorial topics: cardiovascular drugs, neuropharmacology (drugs for neurologic diseases and drugs of addiction), and antimicrobials. Knowledge of these drugs are important in the management of common medical conditions in the community.

Length:

You will complete 10 multiple-choice questions for each pre-work activity before each tutorial block (see Task). Each pre-work activity will run for 15 minutes only.

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Due:

Pre-work activities are accessible in UTSOnline from Thursday to Sunday before each tutorial block (see Task).

Criteria:

The underlying premise for the assessment is accuracy of your disciplinary knowledge, as well as interpretation and application of this information to case scenarios based on medical conditions in the community. The use of clinical case scenarios assesses your development of enquiry oriented learning by conducting thorough research on the topic and providing a comprehensive evaluation of the activity and use of the drugs.

Further information:

Feedback and answers to the pre-work activities will be part of your discussion during the tutorials. If you are absent on the day the of the tutorial, you will be responsible with catching up with the lessons. There are no make up tutorials. If you do not complete a pre-work activity, you’ll receive a zero mark the missed task. There are no make up pre-work activities. If you missed a pre-work activity due to a misadventure or illness, you can submit a medical certificate or other documentary evidence to explain the circumstances to [email protected]. If excused, the missed pre-work activity will not be included in the computation of the final grade.

Assessment task 2: Video project Intent:

To clearly communicate and explain the pharmacology and use of existing or new drugs in a video presentation with the purpose of educating a lay audience This assessment task contributes to the development of the following graduate attributes: 1. Disciplinary knowledge and its appropriate application 2. An Enquiry-oriented approach 3. Professional skills and their appropriate application 5. Engagement with the needs of Society 6. Communication skills

Objective(s): This assessment task addresses subject learning objective(s): 1, 2, 3, 4, 5 and 9 This assessment task contributes to the development of course intended learning outcome(s): 1.0, 2.0, 3.0, 5.0 and 6.0 Type:

Project

Groupwork: Group, individually assessed Weight:

30%

Task:

You will join a group of four members and will work to produce a five-minute video on the topic assigned by the subject coordinator. The topic relates to pharmacology and rational use of drugs. These drugs may come from those discussed in the lectures or those arising from medical research. In UTSOnline, you can access a learning module on how to prepare a digital media presentation. Feedback from the teaching associates can be provided during the tutorial sessions. You may also provide feedback on the draft videos from other groups and may also receive peer feedback on your draft. Instructions about the format or submission process will be provided in UTSOnline.

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You will also assess the contribution of individual members of your group using SparkPlus. You will receive a group grade but individual marks will be moderated based on the results from SparkPlus. Length:

Five-minute video presentation

Due:

11.59pm Friday 19 October 2018 See also Further information.

Criteria:

Your assessment task will be marked based on the following: accuracy and completeness of information, creativity and ability to effectively communicate concepts or ideas and to use of digital media effectively, presentation skills, quality of research, accuracy in referencing the literature, images, music, and other...