Antiglobulin-TESTING AND OTHER TESTS PDF

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ANTIGLOBULIN TEST  It is done in the laboratory especially for the patients with adverse transfusion reaction  Example : - kunwari nagkaroon sila ng transfusion reaction na kung saan nangati sila nahiraan silang huminga, so ang unang ginagawa kapag ganitong investigation at nagpeperform tayo ng antiglobulin testing to find out what have caused the transfusion reaction whether it is in vivo or in vitro at malalaman rin kung ano ang mga particular antibodies and antigen ang naroroon HISTORY 1908

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Moreschi -described the principle of Antiglobulin Test -his stdies used rabbit antigoat to agglutinante rabbit RBCs were senstized with low agglutinating doses of goat anti-rabbit RBC serum Coombs, Mourant, and Race -described the used of the antiglobulin test for the detectingid weak and nonagglutinating Rh andtibodies in serum Coombs, and coworkers -described the use of AHG to detect in vivo sensitization of the RBCs of neonates suffering from HDFN (HDFN - Hemolytic Disease for Fetus and Newborn) Coombs, and Mourant -demonstrated the antibody activity that detected Rh antibodies was associated with the anti-gamma globulin fraction in the reagent Dacie -presented the first evidence that there might be another antibpdy activity preent that influenced the final reaction -he observed that different reaction patterns were obtained when dilutions of AHG were used to test cells sensitisized with warm (IgG, 37 °C) as compared with cold antibodies (IgM,...