Aspirin-level-2-labnotebook PDF

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Aspirinlevel2 Veronica Aims Inlevel2,you'lllearnaboutthechemicalpropertiesofaspirin.You'llgettopurifyyourcrudesamplebyrecrystallisation,werecommendastarting weightof5g,andthenanalyseitusingthinlayerchromatography.

Ineachactivityyou'llbeabletocollectpoints.Attheendofthelevelyoucanrestarttoimproveyourskillsorprogresstothenextchallenge.

Video100Points

Comprehension100Points1Attempt Recrystallisationisaprocedureforpurifyingcompounds. Recrystallisationinvolvesdissolvingyoursampleintheminimumvolumeofsolvent. Ifacompoundisnon-polar,thebestchoiceofsolventinwhichtodissolveitisnon-polar. Afterrecrystallisation,youwouldusuallyexpectthemassofyourproducttohavedecreased. TLCisaprocedureusedtoanalysechemicalcompounds.ItstandsforThinLayerChromatography.

Polarityofaspirin100Points1Attempt

Thecarboxylicacidgroupisstronglypolar. Theestergroupisweaklypolar. Thephenylgroupisnonpolar. Aspirinisapolarmolecule. Ethanolisapolarsolventwhichcanbeusedtorecrystalliseaspirin.

Recrystallisation100Points1Attempt Whiteneedle-likecrystalsformedonrecrystallisation:

Vacuumfiltration100Points Filteredcrystals:

TLCexperiment100Points1Attempt TLCplate: A:Startingmaterial B:Crudeaspirin C:Recrystallisedaspirin

TLCanalysis100Points1Attempt

Rf=

Thedistancefromtheorigintothecompound. Thedistancefromtheorigintothesolventfront.

AspirinRf=0.5. 2-HydroxybenzoicacidRf=0.75.

Key

A:Startingmaterial B:Crudeproduct C:Recrystallisedproduct

Yield100Points1Attempt Amountof2-hydroxybenzoicacidis0.0370mol. Theoreticalyieldofaspirinis6.66g. Percentageyieldofcrudeaspirinis72%. Percentageyieldofpureaspirinis60%.

Review ThingsIdidwellon: estuvobuenalaactividadybastanteinteractiva ThingsIcouldimproveon: RepasarTLC Youhaveendedupwithayieldof60%pureaspirin.Doyouthinkthisrepresentsagoodyieldoverall? Yaquecuandoserecristalizatodaviaquedanatrpadosimpuresas...