BME 205 Spring 2020 Tentative Syllabus PDF

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BME 205 Clinical Challenges of the 21st Century

Spring 2020

3 credits

This course satisfies both SNW and TECH requirements. Class time: Tuesday and Thursday 10:00-11:20am Classroom: Earth and Space Sciences 001 Course Instructor: Meilin Ete Chan, PhD [email protected] Office: Bioengineering 115 Office hours: (to be announced on Blackboard under Faculty Information)

Graduate Teaching Assistant: Christopher Freda ([email protected]) Means of instruction: Lecture/classroom interaction/seminar Reference book: (not required) Course Web page: http://blackboard.stonybrook.edu/. Prerequisites: (none) Technology tool needed: TopHat subscription to be installed on your mobile devices. It is important for our inclass interaction and your quizzes.

Course Description: Technology used by current medical practice, focusing on weekly topics associated with a specific disease state. Technology used to diagnose and treat these disease states will be rigorously examined. Weekly topics will include cancer, cardiovascular disease, Alzheimer's, obesity, diabetes, osteoporosis, osteoarthritis, and organ transplant. Key disease states will be presented in physiological and cellular depth. This course may not be taken for major credit. Course Objectives: • To understand specific disease states at the physiological and cellular level • To understand the process of diagnosis and treatment for these disease states • To understand the technology required for both the diagnosis and treatment • To demonstrate an ability to use Problem Based Learning concepts to identify a disease, and propose the treatment, based on the topics covered • To demonstrate an ability to apply technical tools & knowledge to practical systems & problem solving • Design, understand, build or analyze selected aspects of the human-made world

BME 205 Clinical Challenges of the 21st Century

Spring 2020

3 credits

Course format: Overall class format in a 4-day cycle, for a total of 6 cycles starting from the second week of course: Day 1 and 2 in a cycle (Tue & Day 3 in a cycle (Tue) Day 4 in a cycle (Thurs) Thurs) • In-class meeting for all groups • Presenting groups will • Overview of the week present their solution as a ppt • Group assignments are meant to • Physiology and science on Thurs be completed before coming to • Quiz *.3 about students’ class and finalized during the in• Pathophysiology presentation. class meeting • Technology for diagnosis with • Non-presenting groups will limitations submit their finalized group work • Technology for treatment with at the end of class time. limitations • Presenting groups will submit • Clinical Challenges their finalized group presentation • Epidemiology and World slides by 12pm on Wed. Health • Presenting and NonPresenting Group assignments made available • Quiz *.1 and *.2 about basic anatomy/physiology and specific disease, respectively Attendance:

Attendance is mandatory and necessary in this class (especially if you are receiving TAP or other financial assistance because instructor has to report to the Provost who shows up to class) and it will be monitored along with quizzes and in-class meetings. There is no sign-in sheet for attendance; all attendances are taken with an interactive software Top Hat that should be installed on your mobile devices. (If you are sick) If your absence is excusable because of sickness, then bring the documentation to the Dean of Student’s Office, Cathrine Duffy (Cathrine Duffy ) in the SAC room 222 (more on attendance, below). She must authorize the absence and email the instructor for confirmation. Please never send your confidential medical documentation to the instructor or the teaching assistants. (Special cases) If you have transportation issues, I can be flexible (students have emailed me pictures of fender benders, or flat tires). If there are other real-life problems you need to deal with, I can be flexible (students have needed to get mom to the doctor, or even were sworn in as US citizens). These deals are 1-time excused absences that are planned ahead (before class), and not after the fact. Emergencies are different. (Religious or SBU related events) Using the SBU official site as a guide for any religious observances. [http://www.stonybrook.edu/commcms/provost/_pdf/policies/Guide%20to%20Religious%20Holidays%20201 6-2020.pdf] However, I acknowledge that not all religious observances are listed here; email the instructor with a website that tells about your religious observance in order to be excused from class without Cathrine Duffy’s approval. Also, check your calendars now for SBU related events that you are required to attend due to sports or other activities.

BME 205 Clinical Challenges of the 21st Century

Spring 2020

3 credits

Spring 2018 Week Week 1. 1/28 and 1/30

Week 2&3 Lectures 2/4 and 2/6 In-class group meeting 2/11 Presentations 2/13

Description Overview of the course. Basics of cells, organs, and systems (each cycle of seminar will begin with basics of cell and organ physiology) Introduction to ‘Cases’ and problem-based learning ((Homework: How to avoid Plagiarism?))

(Cycle 1) Brain and Nervous System What is Alzheimer’s disease? • Discussion/lecture on types of neurons in the brain, potential causes of Alzheimer’s, and MRI diagnosis What is Parkinson’s disease? • Discussion/lecture on neural pathways affected, including the role of dopamine and its receptor. Differences in treatment by medication vs Stem Cells

Week 4&5

(Cycle 2) Cardiovascular System

Lecture 2/18 and 2/20

What is cardiovascular disease? • Seminar on cardiovascular disease incidence, causes, diagnosis and treatment • Discussion/lecture on the technology used in diagnosis/treatment (blood chemistry and protein analysis)

In-class group meeting 2/25 Presentations 2/27

Week 6&7 Lecture 3/3 and 3/5 In-class group meeting 3/10 Presentations 3/12

Week 8 Week 9&10 Lecture 3/24 and 3/26 In-class group meeting 3/31

What is heart valve failure? (Dr. Jawaad Sheriff) • Seminar on heart valve failure, incidence, causes, diagnosis and treatment • Discussion/lecture on ways to diagnose heart problems.

(Cycle 3) Musculoskeletal System What is osteoarthritis? • Seminar on osteoarthritis focusing on rheumatoid arthritis. • Discussion/lecture on the immune system’s role in rheumatoid arthritis, and how antiinflammatory drugs work. What is osteoporosis? • Seminar on disuse vs age related bone loss. • Discussion/lecture on how bone density is determined by ultrasound and other methods.

Spring Recess! (Cycle 4) Cancer and Genetic Engineering • • •

Seminar on cancers Discussion/lecture on molecular level detection of cancer, ways for removal/eradication Discussion on evolving treatment strategy such as immunotherapy with CarT cells

Presentations 4/2

Week 11&12 Lecture 4/7 and 4/9 In-class group meeting 4/14 Presentations 4/16

(Cycle 5) Metabolic Disorder and Games for Health • • •

Seminar on diabetes and obesity. Discussion/lecture on how a portable home blood glucose meter works Discussion on how gamification helps in improving health (e.g., exergames)

BME 205 Clinical Challenges of the 21st Century Week 13&14. Lecture 4/21 and 4/23

Spring 2020

(Cycle 6) Transplantation and Tissue Engineering • •

In-class group meeting 4/28 •

Seminar on organ transplant Discussion/lecture on the immune system recognition of self, foreign body rejection, and fabrication of artificial organs Discussion on tissue engineering

Presentations 4/30

Week 15

3 credits

Extra credit opportunities

In-class activity 5/5 and 5/7

*Students must submit a document indicating they understand plagiarism and its consequences.

BME 205 Clinical Challenges of the 21st Century

Spring 2020

Grading: No final exam during finals week. Grading items • Week 1 assignment: How to avoid plagiarism? • 6 Sets of Quizzes - *.1 for Basic Anatomy & Physiology (a%) and - *.2 for Specific Diseases (b%) ▪ where a+b% = 7.5%, approximately 10-15 questions total for participation and correctness - *.3 for Case Study Related Questions (2.5%, i.e., 0.5% from each of the 5 presentations) •

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3 credits

Total 1% 6 cycles X 10% = 60%

1 In-class meeting participation for students in presenting groups 4% - One completed submission of a draft PowerPoint by 12pm on Mon, the day prior to the in-class meeting, with a table showing individual contribution (slides from individual sub-group: 3%) - Attendance (1%) Group presentation 10% - # Completed group submission of a finalized PowerPoint by 12pm on Wed, the day prior to the presentation (6%) - # Submission of three key concept questions (1%) - # Presentation (Individual sub-group + Group) (2+1% = 3%, or 0% if you are absent) 5 In-class meeting participation for non-presenting groups 5 X 5% = 25% - Completed group submission of the finalized non-presenting group assignment by the end of class time (3%) - Participation during the in-class meeting with the instructor/TA (1%) - Attendance (1%) - Note: If you do not come to class, you cannot participate in the meeting, which means you lose 2/5 points : COME TO CLASS!

#: indicates a score given to a group, but an individual will get a zero if he/she is absent or does not participate. (NO ROUNDING UP at the end of the semester) 95 or above = A; 90-94.99 = A-; 85-89.99 = B+; 80-84.99 = B; 75-79.99 = B-; 70-74.99 = C+; 65-69.99 = C; 60-64.99 = C-;...