Cardiac drugs notes PDF

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14.CARDIAC DRUGS1. HEART FAILURETerminology A. Inotrope: force of contraction B. Chronotrope: heart rate i. Can be positive or negative2. INOTROPES: SEPSISSeptic shock is a consequence of a systemic infection characterised by hypotension, unresponsive to fluid resuscitation. 60% patients have cardia...

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14.12.18

CARDIAC DRUGS 1. HEART FAILURE Terminology A. Inotrope: force of contraction B.

Chronotrope: heart rate i.

Can be positive or negative

2. INOTROPES: SEPSIS Septic shock is a consequence of a systemic infection characterised by hypotension, unresponsive to fluid resuscitation. 60% patients have cardiac depression with impaired left ventricular function.

3. SMPATHOMIMETIC AMINES

2

4. DOBUTAMINE

5. MILRINONE

6. INOTROPIC ACTION OF DIGOXIN Digoxin is an inotrope without being a chronotrope

3

7. THE DIG TRIAL The effect of digoxin on mortality and morbidity in patients with severe heart failure.

8. ANGINA

9. GLYCERYL TRINITRATE 4

10.

NITRATE ALTERNATIVES

11.

FIRST B-ADRENOCEPTOR ANTAGONIST: PROPRANOLOL Propranolol (B-adrenoreceptor antagonist) has been described as the greatest breakthrough in the treatment heart disease since the discovery of digitalis.

12.

B-BLOCKERS IN ANGINA

5

13.

B-ADRENOCEPTOR ANTAGONISM

14.

SELECTIVE B-ADRENOCEPTOR ANTAGONIST

15.

B-ADREBICEOTIR ANTAGONISTS 3rd generation: additional pharmacological property ex) bucindolol is also a nitrate

6

16.

B-BLOCKERS AND HEART FAILURE B-blockers reduce heart rate and myocardial contractility and for many years were contraindicated in the treatment of heart failure.

17.

CARVEDILOL

7

18.

BETA BLOCKERS IN CHRONIC HEART FAILURE

19.

CALCIUM ENTRY BLOCKERS IN ANGINA

20.

CALCIUM CHANNEL BLOCKERS

8...