Experiment 2 - lab report PDF

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Experiment #2: Critical Analysis of Chemical Literature I.

Chemical Data and Laboratory Safety a. Acetaminophen (Tylenol) i. CAS registry number: 103-90-2 ii. CAS name: N-(4-hydroxyphenyl)-acetamide iii. Molecular Formula: C8H9NO2 iv. Molecular weight: 151.17 g/mol v. Percent composition: C 63.56%, H 6.00%, N 9.27%, O 21.17 vi. Structure:

b. Ibuprofen i. CAS registry number: 15687-27-1 ii. iii. iv. v.

CAS name: (RS)-2-(4-(2-methylpropyl)phenyl)propanoic acid Molecular Formula: C13H18O2 Molecular weight: 206.29 g/mol Percent composition: C 75.69%, H 8.80%, O 15.51%

vi. Structure:

c. Acetone i. Exposure Control/Personal Protection: face shield/safety glasses d. I didn’t realize that there were potential firefighter measures needed for acetone so that was interesting. Literally everything that would potentially need to be known in any case is included on this report so that is extremely convenient as

you don’t have to look anywhere else although I am confused what the carcinogenicity section means. II.

Finding Spectra a. Derivatives: 4-amino-N-methylphthalimide, 3,4,5,6-tetrofluoro-Nmethylphthalimid b. Spectra #1 (N-methylphthalimide)

III.

Topic and Article Searching a. When searching for acetaminophen, 23222 different searches were found, whereas with acetaminophen delivery systems, only 183 different search results appeared because the search was far more specific b. Filtering the search results for acetaminophen delivery systems in the last 5 years only shows 58 different results c. The effects of ibuprofen when taken in regard to acute pain were observed in this study, and it was found that the median of maximum plasma concentration of fast acting formulations of salts in oral ibuprofen occurred before 50 minutes in comparison to standard formulations of salts that took 90 minutes for maximum

plasma concentration. For this reason, fast acting formulations of ibuprofen had quicker absorption rates, faster initial pain reduction, and good overall analgesia with longer results when given the same dose as those standard formulations compared. i. Moore, R Andrew, et al. Faster, Higher, Stronger? Evidence Formulation and Efficacy for Ibuprofen in Acute Pain. Pain. 2014,

d. Fuller M, Rao NZ. The Effect of Time, Roasting Temperature, and Grind Size on Caffeine and Chlorogenic Acid Concentrations in Cold Brew Coffee. Scientific Reports. 2017, 7, 17979. (Yes this citation is correct)

IV.

Chemical Drawing Software

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