Medications affecting coagulation 02022021 PDF

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Medications affecting coagulation

Mode of Action

Coumadin

Heparin

Lovenox

Coumadin is prescription medicine used to treat blood clots and to lower the chance of blood clots forming in your body.

Prevention of thrombus formation. Prevention of extension of existing thrombi (full dose). Prophylaxis and treatment of various thromboembolic disorders, including Venous thromboembolism, pulmonary emboli, atrial fibrillation with embolization, acute and chronic consumptive coagulopathies, peripheral arterial thromboembolism. Used in very low doses (10–100 units) to maintain patency of IV catheters (heparin flush)

Prevention of thrombus formation.

Indications

Prophylaxis and treatment of venous thrombosis and its extension, pulmonar y embolism (PE).

Prevention of deep vein thrombosis (DVT) and pulmonary embolism (PE) in surgical and medical patients. Treatment of DVT (with warfarin). Prevention of ischemic complications (with aspirin) from unstable angina, non–Q-wave MI.

Dosage/Route

PO: 1mg-10mg

Side Effects

Hemorrhage Tissue Necrosis Acute Kidney Injury

Pain at injection site Anemia Bleeding Osteoporosis Drug-induced hepatitis

Labs to Monitor

PT/INR

activated partial thromboplastin time (aPTT)

Dizziness Nausea Headache Reversible increased liver enzymes Bleeding Anemia activated partial thromboplastin time (aPTT)

Antidote

Vitamin K

Protamine sulfate

Protamine sulfate

Patient teaching

Higher risk for bleeding

Routine bloodwork

Bleeding or

Avoid drinking alcohol Avoid foods high in vitamin K Increased risk for injury

to monitor for hepatitis and aPTT Increased risk for injury and bleeding Avoid drinking alcohol Watch for rash Report pain at site

bruising easily Black or bloody, tarry stools Hypotension Back pain Avoid drinking alcohol...