Methergine PDF

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Summary

Drug study for Methergine....

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Section:

COLLEGE OF NURSING PHARMACOLOGY

Brand Name: Methylergometrine Maleate Dosage, Route & Frequency Recommended Prescribed PO (Adults): 200– 400 mcg (0.4– 0.6 mg) q 6– 12 hr for 2– 7 days. IM, IV (Adults): 200 mcg (0.2 mg) q 2– 4 hr for up to 5 doses.

Generic Name: Methergine Drug Action Directly stimulates uterine and vascular smooth muscle. Therapeutic Effects: Uterine contraction. Pharmacokinetics Absorption: Well absorbed following oral or IM administration. Distribution: Unknown. Enters breast milk in small quantities. Metabolism and Excretion: Probably metabolized by the liver. Half-life: 30– 120 min.

Drug-Drug & DrugFood Interactions DRUG: Excessive vasoconstriction may result when used with heavy cigarette smoking (nicotine), other vasopressors, such as dopamine, or beta-blockers. FOOD: Grapefruit juice may increase levels.

Responsibilities in the Nursing Process (ADPIE) Assessment: Assess for signs of ergotism (cold, numb fingers and toes, chest pain, nausea, vomiting, headache, muscle pain, weakness).

Drug Classification: Drugs for pain control, Ergot Alkaloids Indications Prevention and treatment of postpartum or postabortion hemorrhage caused by uterine atony or subinvolution.

Contraindications Contraindicated in: Hypersensitivity; OB: Should not be used to induce labor; Lactation: Do not breast feed during treatment and for 12 hours after the last dose; Concurrent use of potent CYP3A4 inhibitors.

Side Effects (By System) CNS: dizziness, headache. EENT: tinnitus. GI: nausea, vomiting GU: cramps. Derm: diaphoresis.

Adverse Reactions (By System) CNS: STROKE CV: HYPERTENSION, arrhythmias, AV block, chest pain, palpitations. Neuro: paresthesia

Misc: allergic reactions.

Responsibilities in the Nursing Process (ADPIE) Intervention: Monitor BP, heart rate, and uterine response frequently during medication administration. Notify health care professional promptly if uterine relaxation becomes prolonged or if character of vaginal bleeding changes.

Diagnosis: Acute pain Evaluation: Contractions that maintain uterine tone and prevent postpartum hemorrhage. Planning: To produce contractions that maintain uterine tone and to prevent postpartum hemorrhage....