Metyrosine PDF

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Medication CArd...

Description

METYROSINE (me-tye'roe-seen) Demser Classifications: HORMONES AND SYNTHETIC SUBSTITUTES; ENZYME INHIBITOR Pregnancy Category: C

Availability 250 mg capsules

Actions Blocks the enzyme tyrosine hydroxylase to inhibit the conversion of tyrosine to DOPA, which is the initial and rate-setting step in synthesis of catecholamines (dopamine, epinephrine, norepinephrine).

Therapeutic Effects In patients with pheochromocytoma, reduces catecholamine synthesis as much as 80%, ameliorating hypertensive attacks and associated symptoms.

Uses Short-term management of pheochromocytoma until surgery is performed, in long-term control when surgery is contraindicated, and in patients with malignant pheochromocytoma.

Unlabeled Uses Has been used in selected patients with schizophrenia to potentiate antipsychotic effects of phenothiazines.

Contraindications Control of essential hypertension. Safety during pregnancy (category C), lactation, or in children...