Pharmacology ANS & Receptors PDF

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ANS (Homeostatic Control: Heart Rate, GI Activity, Visceral F(X)’s) | Location: Stem Preganglionic fibers leave the brain stem and spinal cord  Release Ach onto Nicotinic cholinergic receptors (Na Ion channel) Postganglionic fibers leave the autonomic ganglia  Sym branch: release Norepi onto adrenergic  Para branch: release Ach onto muscarinic receptors Parasympathetic “Calms the body” | Location: Brain stem & Spinal Segs S2-4  Specific, and not systemic  Releases Ach  Associated with the phospholipase C system (DAG->Calmodulin/IP3->Ca)  Protein Kinase C)  Cholinergic – Discrete activation (Muscarinic) Sympathetic “Fight or Flight” | Location: Lateral Gray Horns T1-L2  Systemic effects  Releases Norepinephrine  Associated with the Adenylyl Cyclase System  cAMP  Protein Kinase A  Adrenergic – Diffuse Activation (Alpha 1 & 2 | Beta 1, 2, 3) Adrenal Glands Sym: Massive release of epinephrine Para: Background or tonic release to help regulate vaso-motor tone Alpha 1 (G0 Transducir, Muscarinic)  Vasoconstriction, (+) BP  (+) Peripheral Vascular Resistance  Mydriasis  Inhibits the insulin receptor Alpha 2 (G inhibit)  Autoreceptor, presynaptic  Smooth muscle contraction  Neurotransmitter inhibition Adrenoceptors Beta 1 Mediate: (G-stimulatory)  Tachycardia  (+) Lipolysis  (+) Myocardial contraction Beta    

2: (G-Stimulatory) Vasodilation (-) Peripheral Vascular Resistance (+) Glycogenolysis and glucagon release Relaxation of bronchiolar and uterine smooth muscle...