Pharmo 2 outline PDF

Preview

Summary

Outline ...

Description

SUBJECT OUTLINE 91709 Pharmacology 2 Course area

UTS: Science

Delivery

Spring 2019; City

Credit points 6cp Requisite(s)

91707 Pharmacology 1 These requisites may not apply to students in certain courses. See access conditions.

Result type

Grade and marks

Attendance: Lectures: 3 hpw. Tutorials: 2 hpw (see Program)

Subject coordinator Pharmacology lecturer and subject coordinator Name: Dr Francis Geronimo Email: [email protected]

Teaching staff Dr Francis Ruel Geronimo ([email protected]) Dr Yiguang Lin ([email protected]) Dr Valery Combes ([email protected]) Professor Graham Nicholson ([email protected]) Dr Eileen McGowan ([email protected]) Dr Lana McClements ([email protected]) Dr Laura Batmanian ([email protected]) Preethi Thiagarajan ([email protected]) Nick Olsen

Subject description This subject develops and extends the principles governing drug and xenobiotic action covered in 91707 Pharmacology 1. It is designed to foster a problem-solving approach to pharmacology with particular emphasis on applying molecular pharmacology concepts to pathophysiological problems. The objectives are to further develop the concept of receptors as cellular determinants of drug and xenobiotic action, and to develop the concepts of modulated receptors and ion channels in determining drug action. Selective toxicity in the treatment of microbial, viral and protozoal infections is examined as well as toxicokinetic factors, defense mechanisms, cellular reactivity, receptors and binding sites as determinants of target organ toxicity. The clinical efficacy of the major pharmacology drug classes used in the treatment of cancer, affective and psychotic illnesses, cardiovascular disease, lipid disorders, blood disorders, diabetes, peptic ulcers, nausea and vomiting, and disorders of the respiratory and musculoskeletal systems, are examined. In addition, the abuse of drugs is examined including tobacco, alcohol, CNS stimulants, psychotomimetics and the mechanisms underlying drug dependence, including treatment of drug overdose and antidotal therapy in the context of clinical toxicology. Lectures are complemented by a tutorial program which emphasises the clinical nature of the subject and develops lecture material using a variety of tutorial and case study approaches.

15/07/2019 (Spring 2019)

© University of Technology Sydney

Page 1 of 11

Subject learning objectives (SLOs) Upon successful completion of this subject students should be able to: 1. Compare and contrast the principles of pharmacotherapy of bacterial, viral and protozoal infections. 2. Summarise the qualitative and quantitative aspects of drug addiction (such as psychotomimetics, stimulants, and nicotine), tolerance, and withdrawal, and relate these to the treatment of dependence. 3. Compare and contrast the qualitative and quantitative aspects of drugs, drug classes, and drug toxicity of chemotherapeutic agents for cancer and prevention. 4. Differentiate the pharmacology and therapeutic uses of drugs used in the treatment of psychoses, depression, Parkinson's disease, and Alzheimer's disease. 5. Apply the principles of pharmacotherapy and secondary prevention of cardiovascular disorders such as acute coronary syndromes, heart failure, and hypertension. 6. Explain the different aspects involved in drug development and design, including clinical trials, pharmaceutical timelines, budgets and funding, role of biomarkers in clinical trial end points, and surveillance of adverse effects. 7. Describe the use of monoclonal antibodies as both diagnostic and therapeutic agents. 8. Describe the pharmacology and therapeutic uses of common neuropeptides and of drugs that target peptic ulcer disease, gastric motility, and nausea. 9. Clearly communicate the pharmacology and therapeutic applications of major groups of drugs to an general audience using a range of audio-visual tools.

Course intended learning outcomes (CILOs) This subject also contributes specifically to the development of following course intended learning outcomes: An understanding of the nature, practice and application of the chosen science discipline. (1.0) Encompasses problem solving, critical thinking and analysis attributes and an understanding of the scientific method knowledge acquisition. (2.0) The ability to acquire, develop, employ and integrate a range of technical, practical and professional skills, in appropriate and ethical ways within a professional context, autonomously and collaboratively and across a range of disciplinary and professional areas, e.g. time management skills, personal organisation skills, teamwork skills, computing skills, laboratory skills, data handling, quantitative and graphical literacy skills. (3.0) An awareness of the role of science within a global culture and willingness to contribute actively to the shaping of community views on complex issues where the methods and findings of science are relevant. (5.0) An understanding of the different forms of communication - writing, reading, speaking, listening - including visual and graphical, within science and beyond and the ability to apply these appropriately and effectively for different audiences. (6.0)

Contribution to the development of graduate attributes This subject addresses the following Science Graduate Attributes: Graduate attribute 1. Disciplinary knowledge During the lecture and tutorials, you will learn the pharmacological principles of drugs used to treat cardiovascular disease, mental disorders, nervous system diseases, neoplasms, infectious diseases, and autoimmune diseases. Your understanding of the concepts in this subject will be applied to discussions of the pharmacology and rational use of drugs presented in an assessment task using clinical case scenarios. For the video project, you will learn about new drugs and compare them with existing recommended therapeutic agents. Your comprehension and competency of pharmacology will also be assessed in the tutorial activities and in the final exam. Graduate attribute 2. Research, inquiry and critical thinking Using the textbook and the lecture handouts as your guide, you can enhance your learning experience by reading relevant published scientific literature. To support this approach, you are provided with pre-class activities for the

15/07/2019 (Spring 2019)

© University of Technology Sydney

Page 2 of 11

tutorials as well as videos and questions prior to the lecture. You will read, evaluate and compare articles from peer-reviewed journals in order to complete the tasks required for the video project. Graduate attribute 3. Professional, ethical and social responsibility For this subject, you will need excellent time management and organisational skills in order to complete the assessment tasks on time. To gather information and to coordinate activities with your subject coordinator, peers and other UTS staff, you will exercise professional and ethical behaviour. Using clinical case scenarios in the tutorials, you will learn how to apply your knowledge about pharmacology, including the rational use of drugs for medical conditions. Similar skills will be applied when you create your video project. Graduate attribute 4. Reflection, innovation and creativity Drugs are an important part of the management of medical conditions in the community. New drugs and new pharmacologic activities of existing drugs are discovered and developed to address new problems of existing diseases, to treat new diseases, or to replace older drugs. For the clinical case scenarios in the tutorials, you will discuss the recommended drugs for selected medical conditions as well as identify the associated side effects and their management. For the video project, you will prepare a visual presentation about a drug to educate your viewers about the evidence for the drug’s approved use. Graduate attribute 5. Communication Through the assessment tasks in this subject, you will further develop your academic and professional written and verbal communication skills. Through the clinical case scenario analyses and the video project, you should be able to clearly and effectively convey the pharmacologic concepts of drugs and their application.

Teaching and learning strategies To utilise the in-class session time efficiently, you are encouraged to always read the relevant preparation material before coming to class. You will find the recommended textbook, lecture handouts, pre-class videos and pre-class questions in UTSOnline. Please bring your relevant notes to every tutorial session. You will have time during the session to discuss the content with your peers and make further notes to consolidate your pre-class learning. Subject content will be delivered as interactive lectures which include discussion of cases and questions related to the lecture topics. In preparation for the interactive lectures, view the pre-lecture videos and questions for selected topics in UTSOnline. There will also be a revision session about the completed lectures. Feedback to these questions are available immediately after completion of the revision activity. In addition to the lectures, you must attend tutorial classes (see Program). These two-hour tutorials expand, reinforce, and supplement theoretical material from lectures through clinical case scenarios. In UTSOnline, you can access the tutorial materials containing the clinical case scenarios. In preparation for the tutorials, you must read the associated lecture materials and the questions about the clinical case scenarios. These tutorials will cover three major topics: cardiovascular drugs, neuropharmacology, and antimicrobials. During the tutorial sessions, you will participate in the discussion of the answers to the questions and also receive feedback on your understanding of the cases and pharmacology principles from your peers and tutors. Discussions will involve analysis of the clinical case scenarios and correlating them with the pharmacology of the drugs. Verbal feedback from your tutor will also be given during these sessions. During every tutorial, there will be an assessment task using clinical case scenarios (see below for more information).

Content (topics) Concepts of drug efficacy, side effects, drug-receptor interactions, genetics, agonists, and antagonists at an advanced level relevant to medicine, industry and research Clinical efficacy of the major pharmacology drug classes used in the treatment of: cardiovascular disorders, addiction, upper gastrointestinal disorders, nausea and vomiting, microbial infections, neoplastic disorders, psychiatric conditions (including depression, anxiety, and psychosis) and neurodegenerative conditions (such as Parkinson's and Alzheimer's diseases) New drug indications, drug development, and clinical trial pathways

15/07/2019 (Spring 2019)

© University of Technology Sydney

Page 3 of 11

Program Week/Session

Dates

Description

Week 1

22 JUL

Orientation Notes: No tutorial sessions. Tutorials start in Week 4.

Week 2

29 JUL

30 JUL: Neurodegenerative diseases 31 JUL: Antidepressants Notes: No tutorial sessions. Tutorials start in Week 4.

Week 3

05 AUG

06 AUG: Pharmacology of addiction; Stimulants and psychostminulants 07 AUG: Antipsychotics Notes: No tutorial sessions. Tutorials start in Week 4.

Week 4

12 AUG

13 AUG: Antibiotics 14 AUG: Antivirals Notes: Tutorials: Drugs for neurologic diseases and drugs of addiction Block 1: 12 - 15 Aug (see Additional Information below)

Week 5

19 AUG

20 AUG: Antifungals; Antimalarials 21 AUG: Antihypertensive drugs Notes: Tutorials: Drugs for neurologic diseases and drugs of addiction Block 2: 19 - 22 Aug (see Additional Information below)

Week 6

26 AUG

27 AUG: Diuretics; Lipid-lowering drugs 28 AUG: Drugs to treat heart failure Notes: Tutorials: Antimicrobials Block 1: 26 - 28 Aug (see Additional Information below)

15/07/2019 (Spring 2019)

© University of Technology Sydney

Page 4 of 11

Week 7

02 SEP

03 SEP: Drugs to treat acute coronary syndrome; Anticoagulants, antiplatelets, and thrombolytics 04 SEP: Antiarrhythmics Notes: Tutorials: Antimicrobials Block 2: 02 - 04 Sep (see Additional Information below)

STUVAC

09 SEP

STUVAC Notes: No tutorials

Week 8

16 SEP

17 SEP: Non-steroidal anti-inflammatory drugs; Drugs to treat peptic ulcer disease 18 SEP: Uric acid and gout Notes: No tutorials

Week 9

23 SEP

24 SEP: Cancer chemotherapy 25 SEP: Drugs to treat nausea and vomiting Notes: Tutorials: Drugs to treat cardiovascular diseases Block 1: 23 - 26 Sep (see Additional Information below)

Week 10

30 SEP

01 OCT: Revision 1 02 OCT: Clinical toxicology Notes: Tutorials: Drugs to treat cardiovascular diseases Block 2: 30 Sep - 03 Oct (see Additional Information below)

Week 11

07 OCT

08 OCT: Drug design and development 09 OCT: Immunosuppresive agents Notes: Tutorials: Cancer chemotherapy Block 1: 08 - 10 Oct, 14 Oct (see Additional Information below)

15/07/2019 (Spring 2019)

© University of Technology Sydney

Page 5 of 11

Week 12

14 OCT

15 OCT: Revision 2 16 OCT: Monoclonal antibodies Notes: Tutorials: Cancer chemotherapy Block 2: 14 - 17 Oct (see Additional Information below) Video project due date: 18-Oct, 11:59 PM SparkPlus due date: 18-Oct, 11:59 PM

Additional information LECTURES Lectures are scheduled on Tuesdays 15:30 - 17:30 and Wednesdays 16:00 - 17:00. TUTORIALS In your tutorial sessions you will be working with one tutor throughout the teaching session. These may be full-time members of the School of Life Sciences or part-time staff with relevant backgrounds and experience in teaching science. You will meet your tutors during your first tutorial session. During every tutorial session, you must complete a test based on the lectures discussed in the previous weeks (see Assessment Tasks). You will learn to apply your learning using clinical case scenarios. There are not make up tutorial classes. Please consult your peers if you miss any tutorial activity. QUERIES If you have any queries regarding the subject or the tutorial content, such as timetable conflicts, lecture notes, etc, please send your email to [email protected]. For help with any aspect of the lecture content, please contact the relevant lecturer. For help on anything that affects your ability to complete the assessment tasks, please send your email to [email protected] with an accompanying supporting document or medical certificate.

Assessment Assessment task 1: Video project Intent:

This assessment task contributes to the development of the following graduate attributes: 1. Disciplinary knowledge 2. Research, inquiry and critical thinking 3. Professional, ethical and social responsibility 4. Reflection, innovation and creativity 5. Communication

Objective(s): This assessment task addresses subject learning objective(s): 1, 2, 3, 4, 5 and 9 This assessment task contributes to the development of course intended learning outcome(s): 1.0, 2.0, 3.0, 5.0 and 6.0

15/07/2019 (Spring 2019)

© University of Technology Sydney

Page 6 of 11

Type:

Project

Groupwork: Group, individually assessed Weight:

30%

Task:

To clearly communicate and explain the pharmacology and use of existing or new drugs in a video presentation with the purpose of educating a general audience. You will join a group and will work to produce a five-minute video on an assigned topic. The topic relates to pharmacology and rational use of drugs. These drugs may come from those discussed in the lectures or those arising from medical research. In UTSOnline, you can access a learning module on how to prepare a digital media presentation. Feedback from the teaching associates or peers can be provided during the tutorial sessions. Instructions about the format or submission process will be provided in UTSOnline. You will also assess the contribution of individual members of your group using SparkPlus. You will receive a group grade but individual marks will be moderated based on the results from SparkPlus. Additional resources for your video project can be found at https://www.digitalmediaforlearning.com/for-students

Length:

Five-minute video presentation

Due:

11.59pm Friday 18 October 2019

Criteria:

Your assessment task will be marked based on the following: the accuracy and completeness of information, creativity and the ability to effectively communicate the concepts or ideas and to use digital media effectively, presentation skills, quality of research, accuracy in referencing the literature, images, music, and other video footages, and the ability to put the topic into broader context. Individual contribution to the group task will be assessed using SparkPlus. SparkPlus will be used to moderate individual grades.

Further SparkPlus information: Using SparkPlus, you will provide anonymous feedback on the performance and contribution of your peers during the development of your video project. Your final grade will not be affected by the outcome of SparkPlus. In Week 12, you have to complete your feedback in SparkPlus. The mark for the video project will be moderated for each individual based on the outcome of SparkPlus. Completion of SparkPlus feedback is compulsory. You lose 20% of your grade for this task if you do not complete the SparkPlus. Late Submissions If you are unable to comply with the due date, you can apply for a Special Consideration or provide appropriate documentary evidence to [email protected]. Late submissions within a week from the due date will receive a penalty of 10% deduction from the score for this task. Late submissions received more than a week from the due date will receive a penalty of 20% deduction from the score for this task. Projects submitted more than two weeks from the due date will not be accepted. No projects should be submitted via email.

15/07/2019 (Spring 2019)

© University of Technology Sydney

Page 7 of 11

Assessment task 2: Clinical case scenario analysis Intent:

To determine the depth of your understanding and knowledge of pharmacology for drugs and its rational use in clinical practice This assessment task contributes to the development of the following graduate attributes: 1. Disciplinary knowledge 2. Research, inquiry and critical thinking 3. Professional, ethical and social responsibility 4. Reflection, innovation and creativity 5. Communication

Objective(s): This assessment task addresses subject learning objective(s): 1, 2, 3, 4, 5, 6, 7, 8 and 9 This assessment task contributes to the development of course intended learning outcome(s): 1.0, 2.0, 3.0, 5.0 and 6.0 Type:

Quiz/test

Groupwork:

Individual

Weight:

30%

Task:

During the tutorials, you will answer short-answer or multiple choice questions about the pharmacology of the drugs and their clinical uses. These tests are compulsory and are closed book.These assess your understanding of the topics discussed in the lectures.

Due:

The questions must be answered within the allotted time during the tutorials.

Criteria:

You ...