summary of Medications for examinations used in the module PDF

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Summary

ACE – Ramipril 1 titrated upto 10mg, with or without food Mode of action ACE inhibitors block the action of the ACE, to prevent the conversion of angiotensin I to angiotensin II decrease the breakdown of bradykinin. Angiotensin II is a vasoconstrictor and stimulates aldosterone secretion. Blocking i...

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ACE–Ra mi pr i l1. 2 5 mgt i t r a t e du p t o1 0 mg , wi t horwi t h ou tf o o d Mod eo fa c t i on

ACEi n h i b i t o r sb l o c kt h ea c t i o no ft h eACE, t opr e v e ntt hec onv e r s i o no fa ng i o t e ns i nIt oang i o t e ns i nI I de c r e a s et hebr e akdo wno fbr ady ki ni n. An g i o t e n s i nI Ii sav a s o c o n s t r i c t o r a nds t i mu l a t e sa l d o s t e r o n es e c r e t i on . Bl o c ki n gi t sa c t i o nr e d u c e sa f t e r l o a d ,wh i c hl o we r sBP I t d i l a t e st h ee ffe r e n tg l o me r u l a ra r t e r i o l e , wh i c hr e d uc e si n t r a g l o me r u l a rp r e s s u r ea n d s l o wst h epr o gr e s s i o no fCKD. Re d u c i n gt h ea l d o s t e r o n el e v e lp r o mo t e ss o d i u ma n dwa t e re x c r e t i on . Th i sc a nh e l pt or e d u c ep r e l o a d , wh i c hha sab e n e fic i a le ffe c ti nh e a r tf a i l ur e . c o uns e l l i n g

Wo r ksb y :ma ki n gy o u rbl o o dv e s s e l sr e l a xa n dwi d e n ma ki n gi te a s i e rf o ry o u rh e a r tt op u mpb l o o da r o u n db o d y s t Si dee ffe c t s–h yp o t e n s i ona f t e r 1 d os e–t a k eb e f or eb e d , d i z z i n e s sd r yc o u g h , h yp e r k a l a e mi a , a n g i oe de ma , wor s e nr e na lf a i l u r e , a v o i dOTCNS AI DS, b l o o dt e s tmo n i t or i n gK+r e n a lf u n c t i on I fy oumi s sado s et a k ei twh e ni ti sne x td u e , d on o tt a k ead o u b l ed o s e Dono ts t o ps u d d e n l y Ma yt a ket i met os ho wa n ye ffe c t , Ke e po u to fs i g h ta n dr e a c ho fc h i l dr e n

Al f a c a l c i d o l–v i t a mi nDa n a l o g u e Vi t a mi nDn e e d sa c t i v a t i o nb yki d n e y s Ki d n e yf a i l ur ec a n td ot h a t Al f a c a l c i d o ld o e s n ’ tn e e da c t i v a t i n g Al f a c a l c i d o ls t i mu l a t e si n t e s t i n a lc a l c i u ma b s o r p t i o n , i n c r e a s e sur i n a r yCae x c r e t i ona n ds e r u mCal e v e l s a nds u p p r e s s e sp a r a t h y r o i dho r mo n es e c r e t i o n . Si dee ffe c t s :Ab d omi n a ld i s c omf o r tr a s ha n di t c h . bl o o dt e s t st oc h e c kc a l c i u m I fy ouf o r g e tt ot a k ead o s e , t a k ei ta ss o o na sy o ur e me mb e r . Ke e po u to fs i g h ta n dr e a c ho fc h i l dr e n

An t i p s y c h o t i c sRi s p e r i d o n e, 2nd– bl o c kpo s t s yna pt i cdo pa mi neD2r e c e pt o r s a nds e r o t o ne r g i c5 HT2 Aa nd hi s t a mi ne 1r e c e pt o ra nt a g o ni s t . I ns c hi z ophr e ni at o omuc hdo pa mi nes one e dt or e duc ei t An t i p s y c h o t i c sc a u s ed o p a mi n eb l o c ka d ei nba s a lg a n g l i a Ex t r a p y r a mi d a ls y mp t o ms( EPSE)a r ec a u s e da sar e s ul t

EPSEa r ep a r ki n s o n i s m,a k a t h i s i a , d y s t o n i a ,d y s ki n e s i a La c kofDo p a mi n er e s u l t si nc h o l i n e r g i ce x c e s s I mp o r t a n tt ob a l a n c ec h ol i ne r g i ca ndd op a mi ne r g i ca c t i vi t yi nt heb a s a lg a n g l i a EPSEf u r t h e rma n a g e db yr e v i e wi n g / r e d uc i n gd o s eo fa n t i p s y c h o t i ct h e r a p y EPSEf u r t h e rma n a g e db yp r e s c r i b i n gp r o c y c l i d i n ea sr e g ul a rme d i c a t i o n c o uns e l l i ng

Si dee ffe c t s2 nd–dr o ws i ne s s ,he a dac he , Sl o wmo v e me nt , mus c l emo v e me nt s , t wi t c hi ng , Pa r k i n s o n ’ ss y mp t o ms ,h i ghp r o l a c t i n ,we i g h tg a i n,d i z z i n e s s , t r e mo r , Ma yt a ket i met os ho wa n ye ffe c t , Dono ts t o ps u d d e n l y Be s tt ob et a k e na tni g h t , i n f o r mo t h e rh e a l t hc a r ep r o f e s s i ona l sa b ou ty o u rt r e a t me n t , n d Si dee ffe c t s2 –s e d a t i o n , we i g h tg a i n ,d i a b e t e s , l i p i dc h a n g e s Br e a s tp a i n , g a l a c t o r r h o e ar i s pe r i d on e-mo n i t o r i n g Ta k ewi t hp l e n t yofwa t e r , don o td r i n ka l c oh o l Mo n i t o r i n g–ph y s i c a lh e a l t hmo n i t o r i n g– Ca r d i o v a s c u l a ry e a r l y Pr o l a c t i ns t a r t , a t 6 mo nt hst h e ny e a r l y PI LL Fo r g e tdo s e s Ke e po u to fs i g h ta n dr e a c ho fc h i l dr e n

Ha l o p e r i d o l1st– bl o c kpo s t s yna pt i cdo pa mi neD2r e c e pt o r si nt hebr a i n Ant y ps y c ho t i c I ns c hi z ophr e ni at o omuc hdo pa mi nes one e dt or e duc ei t An t i p s y c h o t i c sc a u s ed o p a mi n eb l o c ka d ei nba s a lg a n g l i a Ex t r a p y r a mi d a ls y mp t o msa r ec a u s e da sar e s u l t EPSEi n c l u de sp a r k i n s o n i s m,a k a t h i s i a ,d y s t o n i a , d y s ki n e s i a Do p a mi n ed e fic i e n c yr e s ul t si nc h o l i n e r g i ce x c e s s I mp o r t a n tt ob a l a n c ec h ol i ne r g i ca ndd op a mi ne r g i ca c t i vi t yi nt heb a s a lg a n g l i a EPSEf u r t h e rma n a g e db yr e v i e wi n g / r e d uc i n gd o s eo fa n t i p s y c h o t i ct h e r a p y EPSEf u r t h e rma n a g e db yp r e s c r i b i n gp r o c y c l i d i n ea sr e g ul a rme d i c a t i o n Si dee ffe c t s1 s t –d y s t o n i cr e a c t i o n s ,a k a t h i s i a , n e u r o l e p t i cma l i g n a n ts y n d r o me , d r o ws i ne s s , h y p o t e n s i on , e r e c t i l ed y s f u nc t i o n , h y p e r p r o l a c t i na e mi a ,b r e a s tp a i n ,g a l a c t or r h o e a , Mo n i t o rs ymp t o msf o rt a r d i v ed y s ki ne s i a , Re p o r th y p e r p r o l a c t i na e mi a , br e a s tp a i n , g a l a c t o r r ho e a-mon i t o r i n g Smo ki n gs t a t u s–d o s ea d j u s t Ma yt a ket i met os ho wa n ye ffe c t , Mo n i t o rEl e c t r o l y t e sb e f o r et r e a t me nt Pr o l a c t i ns t a r t , a t 6 mo nt hst h e ny e a r l y Ca r d i o v a s c u l a rr i s ky e a r l y ECGb e f or es t a r t i n g Dono ts t o ps u d d e n l yt a ki n g Fo r g e tdo s e PI LL Ke e po u to fs i g h ta n dr e a c ho fc h i l dr e n

ARBs–Lo s a r t a n ,1 2 . 5mg bl o c kt hea c t i o no fa ng i o t e ns i nI Io nt heAT1r e c e pt o r . An g i o t e n s i nI Ii sav a s o c o n s t r i c t or s t i mu l a t e sa l d os t e r o n es e c r e t i o n . Bl o c ki n gi t sa c t i onr e d u c e sa f t e r l o a d , wh i c hl o we r sBP I t d i l a t e st h ee ffe r e n tg l o me r u l a ra r t e r i o l e , wh i c hr e d uc e si n t r a g l o me r u l a rp r e s s u r ea n d s l o wst h epr o gr e s s i o no fCKD. Re d u c i n gt h ea l d o s t e r o n el e v e lp r o mo t e s s o d i u ma n dwa t e re x c r e t i o n . Th i sc a nh e l pt or e d u c ep r e l o a d , wh i c hha sab e n e fic i a le ffe c ti nh e a r tf a i l ur e . Wo r ksb y :ma ki n gy o u rbl o o dv e s s e l sr e l a xa n dwi d e n ma ki n gi te a s i e rf o ry o u rh e a r tt op u mpb l o o da r o u n db o d y s t Si dee ffe c t sh y p o t e n s i o na f t e r1 d o s e–t a k eb e f o r eb e d , d i z z i n e s s , h y p e r k a l a e mi a , wo r s e nr e na lf a i l u r e , a v o i dOTCNS AI DS, c h e c kbl o o dt e s tmo ni t o r i n gK+a n dr e n a lf u n c t i o nb e f or et r e a t me n t Ta k es a met i mee a c hd a y Dono ts t o pt a ki n g I fmi s s e dd o s et h e nt a k et h en e x td o s ea sno r ma l . Dono tt a k ead o u b l ed o s et oma k eu pf o raf o r g o t t e nt a b l e t . Ma yt a ket i met os ho wa n ye ffe c t , Ke e po u to fs i g h ta n dr e a c ho fc h i l dr e n

Mo n i t o re ffic ac yc l i n i c a l l y , r e d uc e ds y mpt o ms ofb r e a t h l e s s n e s si nh e a r tf a i l u r e , i mpr o v e dBPc o n t r o li nh y p e r t e n s i on . As p i r i n–7 5 mg, Mo deo fa c t i on

Th r o mb o t i ce v e n t sh a pp e nwh e nt h r o mb u sf o r msi na r t e r i e s a ndo c c l u de st h ec i r c u l a t i o n . As p i r i ni r r e v e r s i bl yi nhi bi t sc y c l oo xy g e na s e t or e d uc epr o du c t i o no ft hr o mb o x a n ef r o ma r a c hi d o n i ca c i d , wh i c hr e duc e spl a t e l e ta g gr e g a t i o n a l s oi nhi bi t spr o s t a c y c l i n whi c hpr e v e nt spl at e l e ta g g r e g a t i o n a ndt h er i s ko fa r t e r i a l o c c l u s i o n. Th ea n t i p l a t e l e te ffe c to fa s p i r i noc c u r sa tl o wdo s e s a ndl a s t sf o rt h el i f e t i meofap l a t e l e t wh i c hdo e s ntha v en u c l e u st oa l l o ws y n t h e s i sofn e wc y c l o o x y g e na s e s oi twe a r so ffwh e nn e wp l a t e l e t sa r ema d e . p r e v e n th e a r ta t t a c k so rs t r ok e sa n dt op r o l o n gl i f e Si dee ffe c t s–Gii r r i t a t i o n–u s ePPi , r e p o r tu n e x p l a i ne db l e e di n g , b r u i s i n g . Mo n i t o r i n g–a s ka b o u ts i dee ffe c t s Co n t a i n sa s p i r i n .

Dono tt a k ea n y t h i n ge l s ec o n t a i n i n ga s pi r i n wh i l et a ki n gt h i sme d i c i n e . t a k ewi t hf o o d, PI LL Mi s s e dd o s e Dono ts t o pt a ki n gs u d d e n l y Av o i dOTCp a i n ki l l e r s .I b up r o f e n Al c o h o lwi l lwo r s e ni nd i g e s t i on Ke e po u to fs i g h ta n dr e a c ho fc h i l dr e n

Be c l o me t h a s o n eq v a r , c l e n i l– wor kb yc a l mi n gd o wny o u ri mmu n es y s t e m. Th i sr e du c e st h es we l l i n gi ny o u rl u n g st h a t ma ke si td i ffic u l tt ob r e a t h e . p r e v e n t sy o ug e t t i n gs y mp t o mss uc ha s wh e e z i n ga n dc o u g h i n g . Mo deo fa c t i on

St e r o i d sp a s st h r o u g ht h ep l a s mame mb r a n e i n t e r a c twi t hr e c e p t o r si nt h ec y t o p l a s m. Th ea c t i v a t e dr e c e p t o rt h e n p a s s e si n t ot h en u c l e u st omod i f yt h et r a n s c r i p t i o no fg e ne s . Pr o i n fla mma t o r yc y t o ki n e sa n dc h e mo ki n e sa r ed o wn r e g u l a t e d , wh i l ea n t i i n fla mma t o r yp r o t e i n sa r eu p r e g u l a t e d . I nt h ea i r wa y s ,t hi sr e duc e smuc o s a li nfla mma t i o n, wi de nst hea i r wa y s , a ndr e duc e smuc uss e c r e t i o n. Th i si mpr o v e ss y mpt o msa ndr e duc e se x a c e r ba t i onsi na s t h ma . As t hma :t ot r e a ta i r wa y si n fla mma t i o na n dc o n t r o ls y mp t oms Ri n s emo u t ha f t e ru s i n gi t , a v o i do r a lt h r u s h , ma k es u r et h e yh a v et h e i ra c t i o np l a n , Si dee ffe c t s :h oa r s ev o i c e ,t h r u s h Ta k e st i met owo r k Dono ts t o pu s i n gi fy o ug e tb e t t e r I fy ouf o r g e tt ot a k ey o u ri n h a l e r , mi s so u ty o u rf o r g o t t e nd o s ea n dt a k et h en e x td o s ewh e ni ti sdu e . Cl e a ni n h a l e ro n c eawe e k Wa r ms o a p ywa t e r Ke e pa wa yf r o mh e a ta n ddi r e c ts un l i gh t , d on o te x p o s et oh i g ht e mp e r a t u r e s Ke e po u to fs i g h ta n dr e a c ho fc h i l dr e n Ho wt ous ei nh a i l e r

Fi r s t , h o l dt h ei n ha l e ru p r i g h ta n dt a k et h ec a po ff. Che c kt h e r e ’ sn o t h i n gi n s i d et hemo u t h pi e c e . Sh a k et h ei n h a l e rwe l l . Pu tt hei n h a l e ri n t ot h eh ol ea tt h eb a c ko ft h es pa c e r As kt h e mt os i to rs t a ndu ps t r a i g h ta nd s l i gh t l yt i l tt h e i rc h i nu pi ti se a s i e rf o rme d i c i ner e a c ht h e i rl u n g s . Pu tt hema s ko nt h e i rf a c et oma k eas e a lo v e rt h e i rn o s ea ndmo u t h . Th en e x ts t e p sa l lh a p p e ni no n ea c t i o n . En c o u r a g ey o u rc h i l dt ob r e a t h ei na ndo ut . Pr e s st h ec a ni s t e ro nt hei n h a l e ro n c ea n d

g e tt h e mt ob r e a t h ei na n do u ts l o wl y a nds t e a d i l yfiv et i me s . Re mo v et h ema s kf r o mt h e i rf a c e . I fy ou rc h i l dn e e d st ot a k ea n o t h e rd os e , r e mo v et h ema s kf r o mt h e i rf a c e . Wa i t3 0s e c o n d st oami nu t ea n ds h a k et h ei n h a l e ra g a i n . Ri ns i ngy o u rmo ut hwi t hwa t e ra f t e re a c hd o s e h e l p sp r e v e n th o a r s e n e s s , t h r o a ti r r i t a t i o n , a n d i n f e c t i o ni nt h emo ut h. d on o ts wa l l o wt h ewa t e ra f t e rr i ns i ng. Co u l du s eas pa c e rt or e d u c et h e s ep r o b l e ms .

Be t ab l o c k e r s–Bi s o pr o l o l Mo deo fa c t i onh e a r t f a i l ur e

Bi s o p r o l o ls l o wsd o wnt h eh e a r tr a t e a n dma k e st h eh e a r tmor e e ffic i e n ta tp u mp i n gb l oo da r o u n dt heb o d y . r e duc ef o r c eofc ont r a c t i o na nd s pe e dofc onduc t i o ni nt hehe a r t . He a r tf a i l u r eo c c ur swh e nt h eh e a r tmus c l ei s we a ka n du n a b l et op u mp e no u g hbl o o dt os u p pl yt h ebo d y ’ sn e e d . p r o t e c tt h eh e a r tf r o mc hr o n i cs y mp a t h e t i cs t i mu l a t i o n Mo deo fa c t i ona n gi n a

I sac a r d i o d e p r e s s a n ta n dh y p o t e n s i v ea c t i on s . r e d u c eh e a r tr a t e ,c o n t r a c t i l i t ya n dBP be t a b l o c ke r sr e d u c et h ewo r ko ft h eh e a r ta n d x y g e nd e ma n do ft h eh e a r t . t h eo Re d u c i n go x y g e nd e ma n d x y g e ns u p pl y / de ma n dr a t i o, i mpr o v e st h eo wh i c hc a nr e l i e v eapa t i e ntofa n gi n a lp a i n t h a ti sc a u s e db yar e d u c t i o ni nt h eo x y g e ns u pp l y du et oc or o n a r ya r t e r yd i s e a s e . Mo deo fa c t i onAF

βbl o c ke r sr e duc ef o r c eo fc o nt r ac t i o na nd s pe e dofc onduc t i o ni nt hehe a r t . s l o wt h ev e nt r i c u l a rr a t ei na t r i a lfib r i l l a t i o n ma i n l yb ypr ol o ng i ngt her e f r a c t o r ype r i o doft heAVnode .

Si dee ffe c t s–f a t i g u e , c o l de x t r e mi t i e s , h e a d a c h e , GId i s t u r b a n c e ss u c ha sn a us e a , Dono tdr i v eo ro p e r a t ema c hi n e r y Ta k es a met i mee a c hd a y , Ta k e st i met owo r k Dono ts t o ps u d d e n l y Ta k et h en o r ma ld o s ea ss o o na sy o ur e me mbe r a ndt h e nc a r r yo nwi t ht h eu s u a ldo s et h en e xtd a y . Li f e s t y l ea dv i c e PI LL Ma s kh y p o g l y c a e mi a -di z z i n e s s , s l o wsr e s p o n s et ol o wb l o o ds u g a r

Ke e po u to fs i g h ta n dr e a c ho fc h i l dr e n Li mi ta l c o h oldu et od i z z i n e s s

Ci me t i d i ne– Mo deo fa c t i on

Hi s t a mi n eH2 r e c e pt o ra n t a g on i s t r e duc eg a s t r i ca c i ds e c r e t i o n. Pr o mo t e sul c e rhe a l i ng Ac i dp r o d u c e db yt h ep r o t o np u mpo ft h eg a s t r i cp a r i e t a lc e l l , wh i c hs e c r e t e sH+i n t ot h es t o ma c hl u me n i ne x c ha n g ef orK+i n t ot h ec e l l . Th ep r o t o np u mpi sr e gu l a t e db yh i s t a mi ne . Hi s t a mi n ei sr e l e a s e db yp a r a c r i n ec e l l sa n d b i n d st oH2 r e c e p t o r sont heg a s t r i cp a r i e t a lc e l l . H2r e c e p t o r sa r ec o u p l e dt oa de n y l y lc y c l a s et oi n c r e a s e c AMPwh i c ht h e n a c t i v a t e st h ep r o t o np u mp . Bl o c ki n gH2 -r e c e p t or st he r e f o r er e d u c e sa c i ds e c r e t i o n . Si dee ffe c t s–d i a r r h o e a , c o n s t i p a t i o n , h e a da c h ed i z z i n e s s . Ci me t i d i nea n dC. d i ff Ta k ea f t e rme a l s Be s tt a k e na tni g h t Li f e s t y l ea dv i c e Mi s s e dd o s e PI LL Ke e po u to fs i g h ta n dr e a c ho fc h i l dr e n

Cl o p i d o g r e l– Mo deo fa c t i on

Th r o mb o t i ce v e n t so c c u rwh e nt h r o mb u sf o r msi na r t e r i e s a n do c c l u de st h ec i r c u l a t i o n . Cl o p i d o g r e lpr e v e nt spl a t e l e ta g g r e g a t i o na n d r e d uc e st h er i s kofa r t e r i a lo c c l u s i o n b yb i n d i n gi r r e v e r s i b l yt oa de no s i nedi pho s pha t e( ADP)r e c e pt o r s( P2 Y1 2s u bt y p e ) o nt h es u r f a c eofp l a t e l e t s . r e d u c et h er i s kofh e a r ta t t a c k so rs t r o k e s . Si dee ffe c t s–b l e e di n g , GIu p s e ta b d o mi n a lp a i n, d y s p e p s i a ,d i a r r h oe a , Ta k ewi t ho rwi t h o u tf o o d, r e p o r ta n yu n u s u a lb l e e di n g ,b r u i s i n g . Te l ld e nt i s ta b o u ty o u rt r e a t me n t Mi s s e dd o s e s Av o i da l c o h o la si tc a nc a u s ei n d i g e s t i o nwi t ht h i sd r u g Dono ts t o pt a ki n gs u d d e n l y a v o i dOTCp a i n ki l l e r sort e l lp ha r ma c i s t PI LL Ke e po u to fs i g h ta n dr e a c ho fc h i l dr e n

Lo wd o s e so fc l o pi d o gr e lr e q u i r eu pt o

awe e kt or e a c ht h e i rf u l la n t i pl a t e l e te ffe c t . Wh e nr a p i de ffe c ti sn e e de dy o us h o u l dp r e s c r i bea l o a di ngdo s e ,n o r ma l l y3 0 0mgo r a l l yf o rACS

Cl o z a p i n e– Mo deo fa c t i on

I ns c hi z ophr e ni at o omuc hdo pa mi nes one e dt or e duc ei t s e c o nd g e n e r a t i o na nt i p s y c h o t i c t r e a ts y mpt o mso fs c h i z o p h r e n i a :h a l l uc i na t i o n sa ndd e l u s i o n s a c t sa na n t a g on i s tt od o p a mi nea nds e r o t on i nr e c e p t o r s b i n d st ot h edo p a mi n ema i n l yD4b uta l s oD2r e c e p t or c on t r i b u t i n gt ot h ed e c r e a s ei n n e g a t i v es y mp t omsa n de x t r a p y r a mi d a ls y mp t o ms . Pa r t i a ls e r o t o ni n5 HT1Aa g o ni s t ,c o n t r i b ut i n gt ot h e r e d u c t i o no fn e g a t i v es y mp t omsa n d e x t r a p y r a mi d a l s y mp t o msa nd mu s c a r i n i cM1,M2 , M3 , M5 , h i s t a mi n ea n t a g o n i s t . An t i p s y c h o t i c sc a u s ed o p a mi n eb l o c ka d ei nba s a lg a n g l i a Ex t r a p y r a mi d a ls y mp t o ms( EPSE)a r ec a u s e da sar e s ul t EPSEi n c l u de sp a r k i n s o n i s m,a k a t h i s i a ,d y s t o n i a , d y s ki n e s i a Do p a mi n ed e fic i e n c yr e s ul t si nc h o l i n e r g i ce x c e s s I mp o r t a n tt ob a l a n c ec h ol i ne r g i ca ndd op a mi ne r g i ca c t i vi t yi nt heb a s a lg a n g l i a EPSEf u r t h e rma n a g e db yr e v i e wi n g / r e d uc i n gd o s eo fa n t i p s y c h o t i ct h e r a p y EPSEf u r t h e rma n a g e db yp r e s c r i b i n gp r o c y c l i d i n ea sr e g ul a rme d i c a t i o n c o uns e l l i n g

Ta k ewi t hf o o do rwi t h o u t Ta k es a met i mee a c hd a y , Dono ts t o ps u d d e n l y Smo ki n g ,c a ffe i n e–s a mel e v e l s , r i s ki fs t op Te l lh e a l t h c a r es t a fft r e a t i n gy o u Ma yt a kes o met i met os h o wa n ye ffe c t Si dee ffe c t swe i g h tg a i n ,d y s l i p i d a e mi a ,d i z z i ne s s ,d r o ws i n e s s( a l c o h ol ) , d r ymo ut h , r e s t l e s s n e s s , p o s t ur a lh y p o t e n s i o n Cl o z a p i n ebo o kl e t Re p o r t–f e v e r ,s we a t i n g , mu s c l es t i ffn e s s , flul i k es y mp t oms , s o r et h r o a t ,c o n s t i p a t i o n Bl o o d swi l lb emo n i t o r e dr e gu l a r l y , Cl o z a p i n ewi l lb es u p p l i e di fb l o od sa r eOK Mo n i t o r i n g–Bl o odwe e kl y–1 8we e k s , t he ne v e r y4 we e ks Li v e rt e s t , we i g h t i n g ,ECG, Mi s s e dd o s e -t a k ea s a pb u ti fc l o s et ot hen e x td os et h e nwa i tt a k en or ma lt i me I fs t o p p e dt a ki n gf o r2d a y si n f o r md o c t o r Av o i dp e o p l ewi t hh a v i n gi n f e c t i o n s Sa meb r a nde a c ht i me St or ea tr o o mt e mpe r a t u r e , o u to fs i gh ta n dr e a c hofc hi l d r e n PI LL Ke e po u to fs i g h ta n dr e a c ho fc h i l dr e n As ka b o uts i d ee ffe c t s Agr a n ul oc yt os i s

Fl ul i k es y mp t o msc a nb ea ni n d i c a t o ro fmo r es e r i ou sp r o b l e ms Cl o z a p i n ec a nc a u s en e u t r o p e n i aa n dl o wwh i t eb l o o dc e l lc ou n t

Th i sc a nl e a dt oa gr a n u l oc y t o s i s Ag r a nu l o c yt o s i sc a nl e a dt oawe a ke n e di mmu nes y s t e m Th i sr e s u l t si na ni n c r e a s e dr i s ko fi nf e c t i o n Th i sma yr e s u l ti ns e p s i s / ma yp r o v ef a t a l Mo n i t o r i n go fb l o o da i dsr e c o g ni t i o nofa gr a n u l oc y t o s i s

Co t r i mo x a z ol e-s u l f a me t ho xa z o l e> Mo deo fa c t i on

i n h i b i t sb a c t e r i a ls y n t h e s i so fd i h y d r o f o l i ca c i d t r i me t ho p r i m>b l o c k sp r o d u c t i o no ft e t r a h y d r o f ol i ca c i d Ov e r a l l , b l oc k st h eb i o s y nt h e s i so fn uc l e i ca c i d sa nd pr o t e i n se s s e n t ...