14. Hypersensitivity (Table) PDF

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Summary

IMMUNOLOGY SEROLOGY HYPERSENSITIVITY HYPERSENSITIVIT Y TYPE I: (ANAPHYLACTIC ALLERGIC IMMEDIATE) TYPE II: (CYTOTOXIC) INFO DISEASES Immune mediator: IgE Effector cells: Mast cell Basophil Mechanism: Cell bound Ab reacting with Ag to release physiologically active substances Immune mediator: IgG IgM ...

Description

IMMUNOLOGY & SEROLOGY

HYPERSENSITIVITY HYPERSENSITIVITY

INFO

DISEASES * ANAPHYLAXIS

TYPE I: (ANAPHYLACTIC / ALLERGIC / IMMEDIATE)

TYPE II: (CYTOTOXIC)

- Immune mediator: IgE - Effector cells: Mast cell & Basophil - Mechanism: Cell bound Ab reacting with Ag to release physiologically active substances

- Immune mediator: IgG & IgM - Effector cells: RBC, WBC, PLT - Mechanism: Free Ab reacting with Ag on the cell surface

JOYCE ANN S. MAGSAKAY

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ANTIGENS - Plant pollen, house dust, mites, foods (eggs or chocolates)

* ALLERGIC RHINITIS

- Fungal/mold spores, animal danders & hair

* BRONCHIAL ASTHMA

- Penicillin, Antiseptic, Anesthetics, bee sting wasp

* TROPICAL EOSINOPHILIA

- Penicillin, Parasites (W.bancrofti, A.lumbricoides) Venom from bee wasp, hornets, foods (shellfish, peanuts, dairies)

* TRANSFUSION REACTIONS

- Ag present on the RBC

* HEMOLYTIC DISEASE OF THE NEWBORN

- Ag present on the RBC

* ACQUIRED IMMUNE HEMOLYTIC ANEMIA (AIHA)

- Drugs coating the RBC

* IDIOPATHIC THROMBOCYTOPENIC PURPURA (TTP)

- Ag present on the Platelets

* GOOD PASTEUR SYNDROME

- Ag on basement membrane of the lungs & kidney

BS MEDICAL LABORATORY SCIENCE

DIAGNOSIS  IN-VIVO SKIN TEST  CUTANEOUS / PRICK TESTING  INTRADERMAL TEST  IN-VITRO SKIN TEST  RADIOIMMUNOSORBENT TEST (RIST)  RADIOALLERGOSORBENT TEST (RAST)

 DIRECT ANTIGLOBULIN TEST / DIRECT COOMB’S TEST (DAT)  INDIRECT ANTIGLOBULIN TEST / INDIRECT COOMB’S TEST (IAT)

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OLFU VALENZUELA

IMMUNOLOGY & SEROLOGY

HYPERSENSITIVITY

TYPE III: (IMMUNE COMPLEX)

TYPE IV: (DELAYED / TUBERCULIN) TYPE V: (ANTIRECEPTOR / STIMULATORY)

* ARTHUS REACTION

- Aspergillus fumigatus

- Immune mediator: IgG & IgM - Effector cells: Host tissue - Mechanism: Ab reacts with soluble Ag to form complexes that ppt in the tissue

* SERUM SICKNESS

- Horse serum

- Immune mediator: T-cells - Effector cells: Macrophages - Mechanism: Synthesizes T-cell rather than Ab

- Immune mediator: IgG but complement fixing

TYPE VI: MISCELLANEOUS

JOYCE ANN S. MAGSAKAY

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* SYSTEMIC LUPUS ERYTHEMATOUS (SLE)

- Nuclear material

* RHEUMATOID ARTHRITIS (RA)

- IgG

* PULMONARY TUBERCULOSIS (PTB)

- Mycobacterium tuberculosis

* LEPROSY

- Mycobacterium leprae

* CONTACT DERMATITIS

- Dyes, metals, Cathecol

* GRAVE’S DISEASE

- TSH receptor of acinar cells

* MYASTHENIA GRAVIS

- Acetylcholine

* GRAM (-) ENDOTOXIC SHOCK

- Lipopolysaccharide of a g(-) bacteria

* PNH

- defective RBC membrane

BS MEDICAL LABORATORY SCIENCE

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TUBERCULIN SKIN TEST PATCH TEST MANTOUX TEST VOLMER TEST VON PIRQUET TEST

OLFU VALENZUELA...