3233-002 lecture syll Spring 20 130pm PDF

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Download 3233-002 lecture syll Spring 20 130pm PDF

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IMMUNOLOGY Spring Semester 2020 PCB3233 Office Hours/Discussion: Ask questions and view old tests Room: To Be Determined Mon-3:30-4:20pm, Tues-10:30-11:20am, Wed-3:00-3:50pm, Thurs-5:30-6:20pm, Fri-10:30-11:20am Review: Go back over more complex concepts (reteach) Room: To Be Determined Mon-3:00-3:30pm, Wed-10:30-11:00am, Thurs-10:30-11:00am LECTURE SEC. 0002 WEEK 1

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Jan-6 Jan-8 Jan-10 Jan-13 Jan-15 Jan-17 Jan-20 Jan-22 Jan-24 Jan-27 Jan-29 Jan-31 Feb-3 Feb-5 Feb-7 Feb-10 Feb-12 Feb-14 Feb-17 Feb-19 Feb-21 Feb-24 Feb-26 Feb-28 Mar-2 Mar-4 Mar-6 Mar-9 Mar-11 Mar-13 Mar-16 Mar-18 Mar-20 Mar-23 Mar-25 Mar-27 Mar-30

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M, W & F 1:30-2:20

LOCATION: CB2 201

Chapter 1- Elements of the Immune System and Roles in Defense Chapter 1- Elements of the Immune System and Roles in Defense Chapter 1- Elements of the Immune System and Roles in Defense Chapter 2- Innate Immunity: the Immediate Response to infection Chapter 2- Innate Immunity: the Immediate Response to infection Chapter 2- Innate Immunity: the Immediate Response to infection MLK day, Holiday Chapter 3- Innate Immunity: the Induced Response to infection Chapter 3- Innate Immunity: the Induced Response to infection EXAM 1- Chapters 1 & 2 Chapter 3- Innate Immunity: the Induced Response to infection Chapter 3- Innate Immunity: the Induced Response to infection Chapter 4- Structure and the Generation of B-Cell Diversity Chapter 4- Structure and the Generation of B-Cell Diversity Chapter 4- Structure and the Generation of B-Cell Diversity Chapter 4- Structure and the Generation of B-Cell Diversity/Start Chapter 5 Chapter 5- Antigen Recognition by T Lymphocyte Chapter 5- Antigen Recognition by T Lymphocyte EXAM 2- Chapters 3 & 4 Chapter 5-Antigen Recognition by T Lymphocyte Chapter 6- The Development of B Lymphocytes Chapter 6- The Development of B Lymphocytes Chapter 6- The Development of B Lymphocytes Chapter 6- The Development of B Lymphocytes/Start Chapter 7 EXAM 3- Chapters 5 & 6 Chapter 7- The Development of T Lymphocytes Chapter 7- The Development of T Lymphocytes Spring Break Spring Break Spring Break Chapter 7- The Development of T Lymphocytes Chapter 8- T-cell Mediated Immunity Chapter 8- T-cell Mediated Immunity Chapter 8- T-cell Mediated Immunity Chapter 8- T-cell Mediated Immunity/Start Chapter 9 Chapter 9- Immunity Mediated by B Cells and Antibodies EXAM 4- Chapters 7 & 8

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Chapter 9- Immunity Mediated by B Cells and Antibodies Chapter 9- Immunity Mediated by B Cells and Antibodies Chapter 10- Preventing Infection at Mucosal Surfaces Chapter 10- Preventing Infection at Mucosal Surfaces Chapter 10- Preventing Infection at Mucosal Surfaces EXAM 5- Chapters 9 & 10 Chapter 11- Selective Readings from Chapter 11 Chapter 13/14- Selective Readings from Chapter 13 and 14 Chapter 13/14- Selective Readings from Chapter 13 and 14 1:00 pm – 2:50 pm EXAM 6- Chapters 11, 13, & 14 + 75-80% old material (20-25% new material)

INSTRUCTOR: Greg Weigel M.S. Department of Molecular Biology and Microbiology HPA II, Room # 316 Office Telephone: 407-823-1790 UCF Campus Email: [email protected] Office Hours: See discussion times at the top of the syllabus. TAs: Norma Almarales – [email protected] Nicole Escudero – [email protected] Office Hours: The discussion hours are in place of office hours/ email for individual appointment. Alternatively, if your schedule does not accommodate the regular office hours, you may set an appointment time to meet with me (via email, telephone or after class). Email is by far the most efficient way to contact me. Please use your knights email instead of emailing through webcourses. COURSE DESCRIPTION: PCB 3233-Immunology is an overview of the basic principles of the immune response involving cells, tissues and molecules, antigen-antibody interactions, cell-mediated immunity and an introduction to immunopathology. COURSE OBJECTIVES: Upon completion of this course, students will be expected to: 1. State the function of the cells involved in the immune response. 2. Compare and contrast the innate and adaptive immune systems. 3. Describe the role of complement and compare the three pathways of activation. 4. List and describe the molecules, mediators and cells involved in the inflammatory process. 5. Compare and contrast the structure, function and receptors of the immunoglobulins. 6. Define the role of the T-cell receptor and the MHC molecule. 7. Explain the concept of immunoglobulin diversity. 8. Describe the process of antigen recognition by antibodies and T cells. 9. Summarize the important regulatory elements in the immune response. 10. Define immune tolerance. 11. Compare and contrast the immune response to viruses, bacteria, fungi and parasites. 12. List and state the function of the tissues and organs of the lymphoid system. 13. Describe the initial encounter with HIV and how it invades. 14. Compare and contrast HIV with Influenza virus. 15. Compare and contrast the 4 main types of hypersensitivity reactions with regard to causes and clinical manifestations. PREREQUISITES: BSC 2010C

TEXTBOOK and STUDY AIDS:  The Immune System, Peter Parham, Garland Publishing 2014, 4rd edition.  MY WebCourses2 @ UCF will be used for the management of the Immunology course.  You should check the contents of MY WebCourses @ UCF often  PowerPoint presentations are used in the class lectures and will be available on MY WebCourses2 @ UCF.  It is the responsibility of the student to obtain access to the Immunology MY WebCourses2 @ UCF site.  It is also necessary and the responsibility of each student to take comprehensive notes during lecture.  Lectures will be recorded and posted on Webcourses2. (this is subject to change as circumstances occur)

COURSE POLICIES: EXAMS:  There will be 6 lecture exams. The final exam will have approximately 20% new material and 80% comprehensive material for the Immunology lecture course.  There will be ONE make-up exam or alternative test date offered for documented reasons only. 1. Examples of documentable cases considered for make-up or alternative test date (all must be accompanied with documentation). This is not an exhaustive list. 1. Doctors note showing you cannot make it to class, death in family, jury duty, research presentation out of town and grad school interview. These would have to interfere directly with the test date. 2. Vacations, weddings, mission trips…, (anything preplanned prior to class start) will be considered for a make-up if notice is given within the first two weeks of class and accompanying documentation is expected. 2. Most common reasons not granted the one make-up or alternative test date. 1. Vacations, weddings, mission trips…, planned during semester. 2. Any reason without documentation and multiple tests on the same date. 3. Times/dates for notice and taking a make-up exam: 1. Students are expected to contact myself, Nicole and Norma by email prior to or within 12 hours of the missed exam. Extenuating circumstances may be considered. 2. Students are expected to reply to an email about setting a time and date within 24 hours of the email being sent to them regarding the make-up. 3. Students are expected to make- up the exam within 4 working days past the missed exam. Extenuating circumstances may be considered. 4. As soon as possible please email Professor Weigel, Norma, and Nicole. 1. Include in the email: 1. Name ________ 2. Section ___ 3. Exam # you are missing 4. Reason ______ 5. Verifiable documentation if possible, at the time, if not then when documentation will be provided 6. Potential times to take the exam  The final exam is an exception to the one make-up exam and make-ups will be considered for documented cases.  In the case of non-documentable cases or after the one make-up test allowance is used, the lowest test score will be dropped and the final can replace the second lowest score. These two opportunities allow the student to miss two exams and still do well in the course if they have learned the material well. (providing the final is taken)  The final grade will be composed of the 5 highest test scores with possibly counting the final twice if it is higher than the second lowest score. Ex: T1 = 100 + T2 = 100 + T3 = 100 + T4 = 0 +

T5 = 50 + T6 = 100. The lowest (T4=0) is dropped, the second lowest (T5=50) is replaced by the final since it is higher than the 5 th test score. T1+T2+T3+T6+T6 = 500/5= 100 average. (If there is even one test score in the first 5 tests which you do not wish to keep, the final must be taken).  The format for all lecture exams will be left to the discretion of the instructor; however, test questions will most likely be multiple choice, matching and true/false format.  Exams may include the WebCourses @ UCF PowerPoint slides, textbook material, lecture notes and any other material covered in the Immunology course.  It is the student’s responsibility to attend course lectures to obtain any information regarding course announcements or other supplemental course information that is provided during the lecture sessions.  Students must provide their own raspberry colored scantron for each of lecture exam.  Students are expected to be on time for course lectures and lecture exams; and are to bring the necessary materials, pencils, erasers, calculators, student ID and PID numbers to each lecture exam.  Coming late to a test: if a student enters after a different student has finished and left the room the late student can be denied access to take the test.  Academic activity at the beginning of each semester is now required for each course. In

order to document that you began this course, please complete the following online MANDATORY QUIZ by the end of the first week of classes (Jan 10th). Failure to do so will result in a delay in the disbursement of your financial aid. ALTERNATIVE EXAM DATES: These are not typically offered. Religious holidays, jury duty, military service, SAS related cases, and UCF approved team travel are reasons a potential alternative test date would be approved. It is the policy of the University of Central Florida to reasonably accommodate the religious observances, practices, and beliefs of individuals in regard to admissions, class attendance, and the scheduling of examinations and work assignments. If a test or mid-term exam is scheduled on a religious holiday, the university catalog states that students may request an alternate day for the exam and observe the holiday without penalty. It is requested that students notify the instructor at the BEGINNING OF THE SEMESTER for accommodation of religious observances, etc. Alternative exams due to conflicts with other important, scheduled events related to education (university sanctioned team travel) will be considered. LECTURE ATTENDANCE: It is strongly recommended that you attend all lectures. Lecture time will be used to deliver information regarding lecture cancellation, announcements, and changes in lecture materials, changes in exam dates or content and supplementary information. It is your responsibility to attend and obtain ALL needed information regarding this course. COURSE GRADES: Course grades are assigned on an objective basis and without regard to the identity of the student or other departmental, program or scholarship requirements. It is the student’s responsibility to see that their course grades are above any minimum requirements mandated by their department, program or scholarship provider. Your final course grade will be based on your performance on lecture exams. Students will be given information regarding their performance on each of the lecture exams through the Immunology MY WebCourses2. MY WebCourses2 can be accessed through the MYUCF Portal. EMAILS REGARDING GRADES If the answer to your email question can be found in this document, your email may not be responded to. Emails at the end of the semester about grades may not be responded to.

CURVING OF GRADES:

Overall class performance is taken into consideration; factors such as class mean average on lecture exams, student attendance to course lectures and student attitudes, as well as, other student behaviors will all contribute to the instructor’s decision to curve or not to curve grades. Do not count on a curve. GRADING: There will be six lecture exams and the lowest score will be dropped and the final can replace your second lowest score. Do not use Webcourses percentage column or the test average tool. The percentage column can’t be set up to figure out your grade with this grading system, you have to do the math. The test average tool takes all grades for that test into account including the students -1 grades of students who did not take the exam so it will be lower than the actual average of the test. YOU ARE KEEPING YOUR BEST 5 SCORES. If you have a score you want dropped in the first 5 tests, YOU WILL NEED TO TAKE THE FINAL EXAM. If you don’t take the final exam, it will be your lowest test score (final exam = 0) and it will be dropped.

GRADE SCALE: 89.5% = A 79.5% = B 69.5% = C 59.5% = D Below 59.5% = F

WITHDRAWAL: March 20th

Friday

NOTE: LAST DAY FOR WITHDRAWAL

Add – Drop Dates Last day to drop – January 9th Last day to add – January 10th The above date is the last day to withdrawal from courses with an automatic: “W”. After the withdrawal period, a student may withdraw with a grade of “W” or “MW” only as stipulated by the University of Central Florida’s policy. This approval is normally given only for urgent reasons related to extended illness (Medical Withdrawal) or equivalent distress. Otherwise, after the withdrawal date you will receive a “WF” which is a grade of “F”. INCOMPLETE (I) GRADES: The grade of “I” (incomplete) indicates that the student’s work is satisfactory (of passing quality) as of the end of the semester, but has not been completed. The grade of “I” will be given only if the student meets all of the following requirements and UCF policies: 1. The student must have completed a substantial part of the course work. 2. The completed work must be of passing quality. Incompletes are not given to students who are failing the course. 3. The student must demonstrate the existence of hardship that renders it unjust to hold the student to the time limits previously fixed for the completion of the work. When a grade of “I” is given, the instructor’s record of the student’s class work remains until the student completes the course work. Previously completed work (prior to receiving the “I”) is then considered with the final work in assigning the course grade. The grade of “I” does not erase all previous work in the course; rather, it allows the student to repeat the course without paying additional credit-hour and laboratory fees. The grade of “I” simply extends the time allowed for completion of the remaining work. Note: because of the design of the syllabus, this not typically an option.

RE-TAKING THE COURSE: Any student needing to repeat the IMMUNOLOGY course due to failure, withdrawal, medical withdrawal or any other reason will be required to retake all the lecture components and exams. No exceptions will be entertained! ACADEMIC INTEGRITY: Review the code of conduct! As reflected in the UCF creed, integrity and scholarship are core values that should guide our conduct and decisions as members of the UCF community. Plagiarism and cheating contradict these values, and so are very serious academic offenses. Penalties can include a failing grade in an assignment or in the course, or suspension or expulsion from the university. Students are expected to familiarize themselves with the University’s Rules of Conduct (http://www.osc.sdes.ucf.edu/). Tests will be monitored and students found cheating will be dismissed from the class and referred to the Office of Student Conduct. You need to be familiar with its contents, as it will be STRICTLY enforced with NO EXCEPTIONS! CHEATING AND/OR DISHONEST BEHAVIOR:  Cheating will not be tolerated in the lecture or laboratory sessions of this course. The following is considered cheating:  Obtaining, sharing and using prior exams.  Using materials during the exam.  Obtaining answers from another student during an exam.  Allowing another student to see your exam, (exams must be covered and kept on the desk area; uncovered scantrons during examination will receive a red mark to signify a reduction of 5 points from your exam score).  Allowing someone to take your exam for you.  Other behaviors that may contradict the UCF creed, integrity and scholarship core values. DISRUPTIVE or RUDE BEHAVIOR WILL NOT BE TOLERATED:  Disruptive behavior will not be tolerated in this course. o You may be asked to leave the class immediately. o In cases of class dismissal, it will be necessary that you set an appointment time with the instructor to discuss the disruptive/rude behavior prior to your being allowed to return to class.  Inappropriate use of WEBCourses links will result in the immediate and unannounced removal of your access to the site. o In cases of lost WEBCourses access, it will be necessary that you set an appointment time with the instructor to discuss the inappropriate use of the WEBCourses site prior to your access being restored.

The Burnett School of Biomedical Sciences Statement on Academic Integrity 

The Burnett School of Biomedical Sciences holds students to the highest standards of academic conduct. Without exception, students who violate these standards will be reported to the Office of Student Conduct. It is critical that students read and understand the Rules of Conduct described in the student handbook, “The Golden Rule.”

This document describes examples of student misconduct, but the faculty of the Burnett School of Biomedical Sciences want to convey the following positive message to our students: 

The lifelong pursuit of a professional career in biomedical science and its related disciplines is achieved through one’s own hard work.

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If you encounter difficulties in your courses of study, cheating is not the solution. Seek assistance from your instructor, early and often. If you devote the necessary energy and resources to your study, and you are prepared for the coursework, you can achieve success.

Students will be reported to the Office of Student Conduct and disciplinary action will be taken for violation of the following rules. Each rule is stated in full in the Golden Rule document. Here we provide examples that relate best to our courses and discipline. The following (1-6) are violations of the Rules of Conduct and are prohibited: Unauthorized assistance  Examples:  A student copies another student’s answers during an exam.  A student uses notes or electronic devices during an exam when they are not allowed.  A student obtains a lab report from another student who previously took the course, and uses the materials to complete a lab assignment for the class. Both students are in violation of the Rules of Conduct.  Two students work together on an online assignment or exam when they were instructed to work alone.  Cell phone or smart phone usage during and exam Communication to another through written, visual, electronic or oral means  Example: Two students are working on an assignment in the library that the instructor has assigned as an individual assignment. One student is finished with the assignment and offers to allow the second student to use the webpage he has found which contains information related to the assignment. Both students are in violation of the Rules of Conduct. Commercial use of academic material  Examples:  A student takes an ...