BIO 232 Neuromuscular Junction Worksheet PDF

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BIO 232 Neuromuscular Junction Worksheet...

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The Muscular System: Neuromuscular Junction 1.

What insulates each muscle cell? _________________________ endomysium

2.

Synaptic vesicles in the axon terminal of a motor neuron contain what neurotransmitter? _________________________ acetylcholine

3.

An action potential in the axon terminal of a motor neuron opens what type of ion channels? _________________________ voltage-gated calcium channels

4.

By what means of membrane transport does the neurotransmitter leave the axon terminal? _________________________ exocytosis

5.

Binding of neurotransmitter to the receptors on the motor endplate open what type of ion channels? _________________________ chemically gated ion channels

6.

Opening of these channels leads to _______________ depolarization of the motor endplate.

7.

How is the neurotransmitter removed from the synaptic cleft? the acetylcholine diffuses away from the recpeotr site and the ion channel closes 8. As a result of question 6, an action potential is propagated along the _________________ of the muscle cell and down the _______________ T tubules sarcolemma into the cell. 9.

The result of this action potential releases what ion from the terminal cisternae? ________ calcium ions

10.

a. What effect did molecule “X” in the quiz have on the muscle contraction?

Molecule "X" competed with acetylcholine and blocked the ion channel receptor site

b. Explain its mechanism of action. Binding to the acetylcholine receptor sites cause the neuromuscular transmission to be blocked, causeing paralysis of the skeletal muscles c. What drug did molecule “X” act like? _______________ curare

11.

a. What effect did molecule “Y” have on the muscle contraction? It prevented the breakdown of acetylcholine

b. Explain its mechanism of action. Used to treat diseases such as myasthenia gravis, which is muscle weakness due to inadequate acetylcholine stimulation c. What drug did molecule “Y” act like? _______________ neostigmine

12.

a. What effect did molecule “Z” have on the muscle contraction? It mimicked acetylcholine and causes depolarization of the motor end plate

b. Explain its mechanism of action. Molecule "Z" binds to the acetylcholine receptor site and opens the ion channels. It can cause visible muscle tremors or death depending on the dosage.

c. What drug did molecule “Z” act like? _______________ Nicotine...