Biologist Journal 4 About how the body processes alcohol PDF

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BILD 1: The Cell

Biologist Journal #4 Instructions Summary: >250 words of your own ideas (10pts) We would be happy to see a variety of answers! Enzymes and Alcohol “I’ve got the worst hangover,” your roommate says to you at breakfast. “It’s Tuesday,” you reply. “Don’t be like that! I didn’t even drink that much. Like, after 2 drinks I get all red. The other people were drinking way more,” they said. “Like the grad students I work for. They were just pounding back the beers.” You remember now- your roommate works in a chemistry lab, and a grad student in their lab passed their PhD defense and graduated yesterday, and everyone was celebrating. So that explains the drinking. “In any case,” they continue, “you’re taking that biology course, right? Why do I get all red and stuff? My grad student was saying something about some enzyme like ALDH2o r s o me t hi n g , b utnoonewa sr e a l l yma ki n gs e ns ea tt ha tpo i nt . Ug h ,I ’ mg oi n gt og ol i edo wn . ” You’re interested in the question, so you look online… I: Research Using your book, the Internet, and other resources, research what enzymes do in general, what ALDH2 does in particular, and what happens if ALDH2 is not working properly. The resources listed below might be good places to start. II: Organize your thoughts To get your thoughts straight, you organize your notes. Write a brief note to yourself in your own words about enzymes do in general on the molecular level, what ALDH2 does in particular, and what happens on the cellular level if ALDH2 is not working properly. Use at least 150 words in your response. III: Talk to your roommate Write down what you would explain to your roommate about what is going on with the red flush. In your explanation, use the kind of language you would use with your roommate, but remember that they are a chemist and so they will understand best using chemistry jargon. You may also choose to give them life advice. Use at least 100 words in your explanation. Resources that may be useful: About enzymes: Enzymes and the Active Site: https://www.khanacademy.org/science/biology/energy-andenzymes/introduction-to-enzymes/a/enzymes-and-the-active-site BILD 1, UCSD Melinda Owens, Instructor Updated 1-16-20

Campbell Biology: Chapter 8, “An Introduction to Metabolism,”, Concept 8.2 “The free-energy change of a reaction tells us whether or not the reaction occurs spontaneously.” and Concept 8.4, “Enzymes speed up metabolic reactions by lowering energy barriers.” About ALDH2: The Flushing Response to Alcohol: The section “A Primer on the Genetics of Alcohol Metabolism.” in Brooks et al., “The Alcohol Flushing Response: An Unrecognized Risk Factor for Esophageal Cancer from Alcohol Consumption.” PLoS Med. 2009 Mar; 6(3): e1000050. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2659709/

BILD 1, UCSD Melinda Owens, Instructor Updated 1-16-20...