BMS1062 Laboratory 10 result table - students PDF

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BMS1062 Laboratory 10 – Pre-class results table As you complete the pre-class material for Laboratory 10 fill in the results table below. Your answers and the “points-to-ponder” will be discussed further in the online Zoom session.

Section A: Based on the location of abnormal B cells in the spleen by immunofluoresc ence, what type of lymphoma does each patient have? Include your reasoning.

Section B: Which sample karyogram belongs to which patient? What translocation is present?

Section C: Which set of FISH results belongs to

Marvin 65-year-old male

Gertrude 69-year-old female

mantle zone B cells express both IgM and IgD

Germinal centre/follicular B cells are IgM low, IgD high

splenic marginal zone B cells are IgM high, IgD low.

Sample 1 t(14;18)(q32;q21)

Sample 3 deletion of a portion of the long arm of chromosome 7 (7q del)

Sample 2 t(11;14) (q13;q32) mantle cell lymphoma

Sample 2 This translocation puts the IgH enhancer/pro

One more chromosome for no 9.



Sample 1 the translocation t(14;18) (q32;q21)

Agnes 61-year-old female

Sample 3  No translocation occurs  Deletion only

which patient? Include your reasoning.

moter in control of cyclin D1 expression



which places Bcl2 (an important antiapoptotic protein) under the control of the IgH enhancer/prom oter. very high levels of Bcl2 in the cell, preventing apoptosis.

cause the chromosome length to be short rather than transfer them to the new chromosome....