Cilostazol Drug Study PDF

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Drug Study by Catherine Espinosa

Generic Name: cilostazole

Trade Name(s): Pletal

Drug Classification: Therapeutic: antiplatelet agents Pharmacologic: platelet aggregation inhibitors Therapeutic Uses: Reduced symptoms of intermittent claudication (cramping) with improved walking distance

Maximum Dosage/24 hours: 50-100 mg twice daily

Possible Routes of Administration: PO

Usual Dosage and Frequency: 100 mg twice daily (50 mg twice daily if receiving inhibitors of cilostazole metabolism) This Patient’s Dose and Frequency: _____________

Mechanism of Action: Inhibits the enzyme cyclic adenosine monophosphate (cAMP) phosphodieterase III (PDE III), which results in increased cAMP in platelets and blood vessels, producing inhibition of platelet aggression and vasodilation

Adverse Effects: headache, dizziness, hyotension, left ventricular outflow obstruction, palpitations, tachycardia, diarrhea

Nursing Implications:

•Assess patient for intermittent claudication before and periodically during therapy. • •

PO: Administer on an empty stomach, 1 hr before or 2 hr after meals. Lab Test Considerations: May occasionally cause anemia, hyperlipidemia, hypericemia, and albuminuria. May prolong bleeding time.

Patient Teaching: •

Instruct patient to take cilostazol on an empty stomach, exactly as directed.

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Advise patient to avoid grapefruit juice during therapy.

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May cause dizziness. Caution patient to avoid driving or other activities requiring alertness until response to medication is known.

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Advise patient to avoid smoking; nicotine constricts blood vessels...