Citrate Cleavage Pathway steps PDF

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Summary

Lecture by jennifer young, steps of the citrate cleavage pathway transfer between mitochondria and cytoplasm...

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Citr at eC lea vag e Pa thw ay Citrat ate Clea leavag vage Pathw thway Steps overview:  Purpose and Location: Transport Acetyl-CoA, as a Citrate molecule, from Mitochondrial Matrix into Cytoplasm  Location in cells: Mitochondria and Cytoplasm  Enzymes involved: - Pyruvate Carboxylase (Mitochondrial Matrix) (Step 1) - Pyruvate Dehydrogenase Complex (MM) (also Step 1) - Citrate Synthase (MM) (Step 2) - Citrate Transport Protein (Transmembrane) (Step 3) - ATP-Citrate Lyase (Cytoplasm) (Step 4) - Malate Dehydrogenase (C) (Step 5) - Malic Enzyme (indirectly in FAB as well) (C) (Step 6) - Mitochondrial Pyruvate Carrier (Transmembrane) (Step 7)  Cofactors involved: - Mg2+; - Biotin (step 1)  Substrates: - 1 Acetyl-CoA - 1 Oxaloacetate - 1 ATP - 1 NADH + 1 H+ - 1 NADP+  Final Products: - 1 Acetyl-CoA - 1 Oxaloacetate - 1 ADP + 1 Pi - 1 NAD+ - 1 NADPH + 1 H+ - 1 CO2...