Clock test - Lecture notes Social psychology PDF

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Social psychology...

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Clock test  Draw a clock that says 10 past 11  5 points for ∙ 1 for circle ∙ 1 for right order of numbers ∙ 1 for right place of numbers ∙ 1 for 2 clock-hands ∙ 1 for correct time  Can get as worse as that people do not know what to do at all ○ Montreal Cognitive Assessment (MoCa) Test for Dementia  Used in many clinics in NL  Brief 30-question test  Takes around 10-12 minutes to complete  Orientation, short-term memory, executive functions, language abilities, abstraction, attention, animal naming, clock-drawing test (similar to MMSE) Continuum Alzheimer’s disease – Vascular dementia

Mixed dementia in most cases in old age: Alzheimer’s disease in combination with blood vessel changes due to aging  difficult to disentangle Treatment AD ○ No cure for Alzheimer’s disease ○ Pharmacological therapies  Symptomatic drugs: restore imbalanced neurotransmission processes ∙ Acetylcholinesterase inhibitors (AChEIs) increase brain level of Acetylcholine ∙ Memantine normalize glutamate transmission  Disease modifying drugs: change brain symptoms (work in progress) ∙ Drugs that reduce amyloid β production ∙ Drugs that reduce amyloid β aggregation ∙ Drugs that increase amyloid β clearance (immunotherapy) ○

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More than 200 drug development failures in the last 30 years...