Esterification- Synthesis of n-butyl acetate PDF

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Esterification- Synthesis of n-butyl acetate lab report...

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Lab Report for Exterification – Synthesis of n-butyl acetate

Oyinda Adeyemo Lab Partners: Yeabsira Belay & Tyler Jones Lab instructor: Professor Maria Escallon Date: October 6th, 2020

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Objective  To study the reaction and the process used in the micro-scale for the synthesis of n-butyl acetate Materials Shor-necked round bottom flask, thermometer, beaker, analytical balance, stirring vane, test tube, funnel Chemical Index Name of Chemical Molecular Formula Molecular weight Melting point Boiling point

Acetic Acid CH3COOH 60.052 g/mol 16.6°C 117.9°C

1-butanol C4H10O 74.121 g/mol -89.8°C 117.7°C

Procedure  In a 5-mL short-necked, round bottomed flask, place 0.2 g of Dowex, 50x2 ion exchange resin, 0.60 g of acetic acid, 0.74 g of 1butanol and a stirring bar  Attach the addition port with sidearm corked and an empty distilling column  Heat the flask while stirring on a water bath.  Boil the reaction mixture  Stir the mixture to prevent bumping  When a temperature of 91°C has reached, remove the thermometer

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 Allow reaction mixture to reflux so that the vapor condense  When the side-arm fills with condensate, it gets cloudy as the first two-layer separate  Carefully remove the apparatus from the heat, allow it to cool.  Allow the entire upper later in the side arm to run back into the reaction flask  Disconnect the apparatus  Remove the product from the reaction flask with a pipette  Determine its weight and boiling point  Assess its purity by TLC analysis and infrared spectroscopy  The product can be analyzed by gas chromatography on a 10-ft carbowax column  At 152℃, the 1-butanol has a retention time of 2.1 min, n-butyl acetate 2.5 min and acetic acid 7.5 min  Look for the presence of hydroxyl and carboxyl absorption bonds in the IR spectrum. The product can easily be purified by simple distillation. Data and calculation Mass of dowex ion = 0.2023 g Mass of acetic acid ~ 0.6 g Mass if 1-butanol = 0.7395 g Mass of vial with product is 20.50 g Mass of product = 1.08 g Percent yield = ¿

actual yield ×100 % theroretical yield

1. 08 ×100 % 1.5418

= 70.05%

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Discussion The percent yield gotten for this experiment shows that the final product gotten was not 100% pure n-butyl acetate. The total initial mass was 1.5418 g which was gotten from the addition of the dowex, acetic acid, 1-butanol. The percent yield gotten was quite high making the reaction efficient. The purpose of this experiment was understood and achieved Esterification can be used in the pharmaceutical industry as well as the cosmetology industry in the process of making medicine and perfumes from low quality products

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Appendix Yeabsira Belay performed this experiment...