Exam 2019, questions and answers PDF

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PharmacologyandClinicalPharmacyQuestions

PART1(PharmacologyandClinicalPharmacyMCQ)

Question1[1.00pt(s)] Whichof the followingsideeffects ofchlorpromazineandphenothiazineneuroleptics isexplainedbytheirantidopaminergicaction? Drymouth Eruptions Extrapyramidalsyndrome Constipation

Question2[1.00pt(s)] Whichofthefollowingstatementsofclonidineisfalse? Itisacentrallyactingantihypertensive Itincreasesvagaltone Itcanbegiveninthetreatmentofopioids“withdrawal Itiscontraindicatedinangina

Question3[1.00pt(s)] WhichofthefollowingstatementsofmetoclopramideisFALSE Isanantiemetic Reducesantralcontractions Increasesthepressureoftheloweresophagealsphincter Mayberesponsiblefordyskinesias

Question4[1.00pt(s)] Whichofthesemedicationsisnotanenzymeinducer? Carbamazepine Rifampin Phenytoin Erythromycin

Question5[1.00pt(s)]

Tachycardia Mydriasis Relaxationofthebladdersphincter Relaxationoftheintestine

Question6[1.00pt(s)] Adding adrenaline to a lidocaine solution to be administered by subcutaneous injectioncanprolongthedurationoflocalanesthesiaby: Decreasedpermeabilityofthevascularendothelium Precipitationoflidocaine ChangingthepHofthesolution LocalVasoconstriction

Question7[1.00pt(s)] What is the side effect that is not observed during the treatment with tricyclic antidepressants? Drymouth Myocardialtoxicity SkinPigmentation Seizurethresholdlowering

Question8[1.00pt(s)] Whatisthepropertythatbenzodiazepinesdonothave? Antidepressant Anticonvulsant Amnesic MuscleRelaxant

Question9[1.00pt(s)] Thestimulationofbetaadrenergicreceptorscauses: Miosis Bronchoconstriction Relaxationoftheuterus Vasoconstriction

Question10[1.00pt(s)] The pseudoparkinsonian syndrome can be observed after the treatment with the followingmedication: ValproicAcid Diazepam Haloperidol

WhatisthesideeffectthatisnotbeobservedduringthetreatmentwithLevodopa? Dyskinesias Confusion Nauseaandvomiting Impotence

Question12[1.00pt(s)] Whichofthesetreatmentsisnotpartofthetherapeuticarsenalofacne? Retinoids Benzoylperoxide Topicalmacrolide Metronidazole

Question13[1.00pt(s)] Whatisthetherapeuticclassthatdoesnothaveanticholinergicproperties? Tricyclicantidepressants Digitalis Antiparkinsonism Digestiveantispasmodics

Question14[1.00pt(s)] What is the process that may not be adopted to prevent the nephrotoxicity of aminoglycosides? Maintaindiuresiswithfurosemide Monitoringresidualserum Adaptationofdosesaccordingtothecreatinineclearance Correctionofanydehydration

Question15[1.00pt(s)] TheuseoftrihexyphenidylinaParkinson'spatient: Actsondopaminereceptors Actsonthecholinergicsystem Facilitatesthereleaseofdopamine Causesmiosis

Question16[1.00pt(s)] Valproicacidhasallofthefollowingsideeffectsexcept: 

Sedation

Question17[1.00pt(s)] The following agent can be used as a mood stabilizer in bipolar disorder treatment except:  

Valproicacid Carbamazepine Lithium Phenytoin

Question18[1.00pt(s)] What is the state that should not necessarily be performed prior to initiating lithium treatmentasmoodstabilizerstreatment? 

Thyroidfunctiontests Liverfunctiontests Cardiacfunctiontests Bloodelectrolyteslevelstests(tomainlycheckserumsodium)

Question19[1.00pt(s)] The increase in the toxicity of anticoagulants and oral sulfonylureas when combined withanonsteroidalantiinflammatorydrugisdueto: 

Enzymeinhibition plasmaproteinsinteraction plasmatransportersinteractions(Pgp,BCRP) Enzymeinduction

Question20[1.00pt(s)] Thebioavailabilityofadrugadministeredbydirectintravenousrouteis: 

100% 0% Dependentonthehalflifeofthedrug Isunpredictable

Question21[1.00pt(s)] Whichofthefollowingantiinfectivedrugsisnotcontraindicatedwithalcohol? 

Metronidazole Ketoconazole

Question22[1.00pt(s)] Which of the following molecules is not recommended for the treatment of Pseudomonasaeruginosainfections? 

Ceftazidime Piperacillin+Tazobactam Cefotaxime Cefepime

Question23[1.00pt(s)] Which of the following molecules is not recommended for the treatment of E. coli betalactamasecarryingextendedspectrum Cefepime Cetriaxone Imipenem Amikacin

Question24[1.00pt(s)] Which of the following molecules is not recommended in the treatment of Staphylococcusaureusresistanttomethicillin(MRSA)? 

Vancomycin Imipenem Teicoplanine Tygecycline

Question25[1.00pt(s)] Thefollowingantibiotics arecapableof inducingnephrotoxicityeveninpatientswith normalrenalfunction: 

Quinolones Macrolides Aminoglycosides Blactams

Question26[1.00pt(s)] What is the antibiotic that cannot be the cause of QT prolongation with risk of torsadesdePointeandcardiacarrest? 

Azithromycin Amikacin Levofloxacin

Hepariniscapableofinducing: 

Agranulocytosis acuterenalfailure Thrombocytopenia Liverfailure

Question28[1.00pt(s)] Which of the following is not an indication of opiate antagonists (naloxone and naltrexone)? 

Treatmentofopioidwithdrawalsymptoms Treatmentofalcoholwithdrawalsymptoms Treatmentofmorphineoverdose Treatmentofcocaineintoxication

Question29[1.00pt(s)] Adrugthatisusedsafelyinhypertensivepatientswithischemicheartdisease: 

lisinopril minoxidil phentolamine diazoxide

Question30[1.00pt(s)] A diuretic that inhibits carbonic anhydrase enzyme in the proximal tubular epithelial cells: 

amiloride acetazolamide hydrochlorothiazide furosemide

Question31[1.00pt(s)] Incaseofanacuteanginalattack,youshoulddispensewhichofthefollowingdrugs?  

isosorbidemononitrate amlodipine nitroglycerin propranolol

 propranolol diltiazem isosorbidedinitrate amlodipine

Question33[1.00pt(s)] Whatisthetargetofactionoffluoroquinolones:  

thetopoisomerases ribosomes PBPmembrane integrases

Question34[1.00pt(s)] Whichantibioticproducescrystalluria? 

Penicillin Sulfamethoxazole Doxycycline Gentamycin

Question35[1.00pt(s)] WhichofthefollowingisNOTapharmacologicalactionofdigitalis? 

positivechronotropiceffect positiveinotropiceffect increaseinrenalbloodflow decreaseinpreload

Question36[1.00pt(s)] Zidovudineisa(n): 

antiprotease antibacterial reversetranscriptaseinhibitor integraseinhibitor

Question37[1.00pt(s)] Achronichypertensivepregnantwomanmaybetreatedasafirstchoicewith:

fosinopril methyldopa hydralazine

Question38[1.00pt(s)] Progesterone: 

actsuponmembranereceptors isneverusedalonewithoutestrogen increasestheriskofendometrialcancer dominatesthelutealphase

Question39[1.00pt(s)] triphasiccontraceptivepills: 

contain3activemolecules releasetheactiveingredientsin3phases containdifferenthormoneconcentrationsaccordingtothecycle areintendedforwomenwhosmoke

Question40[1.00pt(s)] AdrugthatisNOTusedasafirstlinetherapyforhypertriglyceridemiais:  clofibrate lovastatin niaspan cholestyramine

Question41[1.00pt(s)] Whichofthesedrugscausesenlargementofthegum: 

phenytoin ibuprofen tramadol captopril

Question42[1.00pt(s)] Ethinylestradiolis: 

anendogenousnaturalmolecule issecretedbytheembryo

Question43[1.00pt(s)] Losartanisa(n): 

betablocker ACEI angiotensinIIreceptorantagonist hypokalaemicdiuretic

Question44[1.00pt(s)] Atenololis: 

AnACEI Anonselectivebetablocker Acalciumchannelblocker Morehydrophilicthanpropranolol

Question45[1.00pt(s)] Erectiledysfunctionmaybecausedby: 

sildenafil alprostadil cimetidine goserelin

Question46[1.00pt(s)] Regardingcalciumchannelblockers: 

Verapamilisnotanantiarrhythmic Nifedipineisanantiarrhythmic amlodipinehasavasculartropism Diltiazemisadihydropyridine

Question47[1.00pt(s)] Regardingantidiabeticagents: 

Biguanidesarelesseffectivethansulfonamides Sulfonamidesincreaseinsulinsecretion Biguanidesincreaseinsulinsecretion Glitazonesinhibitalphaglucosidase

Question48[1.00pt(s)]

metronidazole mebendazole iodoquinol chloroquine

Question49[1.00pt(s)] Whichmoleculecancauselacticacidosis: 

Glibenclamide Pioglitazone Repaglinide Metformin

Question50[1.00pt(s)] Whichofthefollowingviraldiseaseshasnoavailablevaccines? 

gastroenteritis commoncold influenza hepatitisA

Question51[1.00pt(s)] Regardingmetformin: 

Itisstronglyhypoglycemic ItstimulatesSUR1receptor Itcausesweightgain Itstimulatesglucoseutilizationbythecells

Question52[1.00pt(s)] Chronicdisseminatedcandidiasisinstablepatientsshouldbeprimarilytreatedby: 

griseofulvin caspofungin fluconazole amphotericinB

Question53[1.00pt(s)] Levodopa: 

Isananticholinergic

Question54[1.00pt(s)] WhichofthefollowingisaLeukotrienereceptorantagonist: 

Zileutin Cromolyn Ipratropium Montelukast

Question55[1.00pt(s)] Phenobarbital: 

Hasashorthalflife IsonlyadministeredIV Isusedinneonatalseizures Isaprodrug

Question56[1.00pt(s)] Indicatethedrugbelongingtoprotonpumpinhibitors: 

Pirenzepine Ranitidine Omeprazole Sodiumbicarbonate

Question57[1.00pt(s)] BNPrisessignificantly: 

Inhypertensivecrisis Inendocarditis Instableangina Inheartfailure

Question58[1.00pt(s)] Whichofthefollowingstatementsistruefororalhypoglycemics? 

Meglitinideisineffectiveinregulatingpostprandialglucose Metforminissuitableforobesepatients Pioglitazoneisharmlesstotheliver  Acarbose can be used for diabetic patients suffering from gastrointestinal tract disturbances andflatulence

 TroponinT BNP LDH CKBB

Question60[1.00pt(s)] Indicatethespecificantidoteforbenzodiazepines: 

Flumazenil Buspirone Zolpidem Triazolam

Question61[1.00pt(s)] Whichofthefollowingagentsisaselectiveserotoninreuptakeinhibitor(SSRI)? 

Lithium Imipramine Fluoxetine Venlafaxine

Question62[1.00pt(s)] Indicatethedrugbelongingtoantacids: 

Pirenzepine Ranitidine Omeprazole Sodiumbicarbonate

Question63[1.00pt(s)] Which of the following drugs does not belong to the class of mucosal protective agents? 

Misoprostol Bisthmussubsalicylate Sucralfate Domperidone

Question64[1.00pt(s)] NYHAstageIIIinheartfailureischaracterizedby:

Nosymptoms ChestPain Nightsweats

Question65[1.00pt(s)] Indicateaperipheraldopadecarboxylaseinhibitor: 

Entacapone Clozapine Carbidopa Selegiline

Question66[1.00pt(s)] Pyelonephritis.: 

isalwaysasymptomatic isabladderinfection isaccompaniedbyfeverandchills isaviralandnonbacterialinfection

Question67[1.00pt(s)] Nitroderivativesarecontraindicatedwhen: 

Systolicbloodpressure140mmHg Thepersonisdiabetic Thepersonisdyslipidemic

Question68[1.00pt(s)] Whichofthefollowingantiparkinsondrugsisusedtotreathyperprolactinemia? 

Benzatropine Bromocriptine Amantadine Levodopa

Question69[1.00pt(s)] Amongthesemolecules,whichisaninhibitorofglycoproteinGPIIb/IIIa: 

Tirofiban Prasugrel

Question70[1.00pt(s)] Tamoxifenisclassifiedas: 

Antiprogestin Antiandrogen Antiestrogen Androgen

Question71[1.00pt(s)] A 19yearold male presents to the emergency room with bacterial meningitis.Which ofthefollowingCephalosporinislikelytobegiventothispatient? 

Cefazolin Cefuroximeaxetil Ceftriaxone Cefoperazone

Question72[1.00pt(s)] Monitoringtheefficacyofatreatmentwithunfractionatedheparinisby: 

INR Platelet Bleedingtime PTT

Question73[1.00pt(s)] ThefollowingisindicatedforAttentionDeficitHyperactivityDisorder(ADHD): 

Methylphenidate Olanzepine Phenytoin Amitryptiline

Question74[1.00pt(s)] Whichofthesemoleculesisadirectthrombininhibitor: 

Hirudin Eptifibatide Amiodarone Furosemide

Multiple blood cultures drawn demonstrate S. aureus resistant to methicillin. Other findings were consistent with endocarditis.Which of the following is an appropriate antibioticinthiscase? 

Ceftriaxone Imipenem Cefazolin Daptomycin

Question76[1.00pt(s)] MonitoringoftheoralanticoagulantantivitaminKtreatmentisby: 

VitaminK INR PTT Plateletassay

Question77[1.00pt(s)] Concerningvalproate,whichofthefollowingisincorrect? 

Itisusedforallformsofepilepsy Itcausesthrombocytopeniaandhepatotoxicityassideeffects Itcanbeusedsafelyduringpregnancy  It can be used for the prophylaxis and treatment of manic episodes in patients with bipolar disorderunresponsivetolithium

Question78[1.00pt(s)] Whatisthemechanismofactionofciprofloxacin? 

Inhibitionofthe30sribosome Inhibitionofthe50sribosome InhibitionofRNAsynthesis InhibitionofDNAgyrase

Question79[1.00pt(s)] Instableanginacrisis,whichoftheseisused: 

Nitroglycerinpatch Subcutaneousisosorbidedinitrate Calciumchannelblockerpatch Sublingualnitroglycerin

Question80[1.00pt(s)]

 Aripiprazole Chlorpromazine Haloperidol Risperidone

Question81[1.00pt(s)] The bactericidal antibiotic that interferes with bacterial cellwall synthesis and that maycause“redmansyndrome”ifinjectedtoorapidlyis 

Piperacillin Vancomycin Gentamicin Clindamycin

Question82[1.00pt(s)] Pregabalinisnotindicatedfor: 

Partialonsetseizure Neuropathicpain Fibromyalgia Depression

Question83[1.00pt(s)] Whichofthefollowingisasideeffectofnitrates:  

Methaemoglobinaemia Hypertensivecrisis Hyperglycemia DecreaseinHDL

Question84[1.00pt(s)] Theantibioticthatirreversiblyinhibitsbacterialproteinsynthesisandwhoseadverse effectsmayincludeototoxicityandnephrotoxicityis: 

Doxycycline Clarithromycin Gentamicin Clindamycin

Question85[1.00pt(s)]

Scopolaminetransdermalpatch Aprepitant Meclizine Diphenhydramine

Question86[1.00pt(s)] Theantibioticwhoseadverseeffectsincludeheartburn,photosensitivity,andpossible depressionofbonegrowthinyoungchildrenis: 

Erythromycin Tetracycline Gentamicin Clindamycin

Question87[1.00pt(s)] DP is a 72 year old man with a documented NSAIDinduced ulcer and is H.pylori negative.HemustcontinuetheNSAIDforosteoarthritis.Whichofthefollowingisthe recommendedmedicationforulcerhealingandpreventionoffutureulcers? 

Sucralfate Nizatidine Aluminumhydroxide Pantoprazole

Question88[1.00pt(s)] Whichantifungaldrugismatchedwithitscorrectmechanismofaction? 

Echinocandinsinhibitpolysaccharide(glucan)synthesisinthecellwall Flucytosinebindstothecellmembrane FluconazoleisanantimetaboliteforfungalRNA AmphotericinBbindstoacytochromeP450dependentenzyme

Question89[1.00pt(s)] Which of the following drugs affecting gastrointestinal function does not cause constipation? 

Anticholinergics Magnesiumantacids Opiates Aluminumantacids

Question90[1.00pt(s)] AhighBUN/bloodcreatinineratioindicates:

Prerenalfailure Acalculusintheurinarytract Acalculusinthebiliarytract

Question91[1.00pt(s)] A22yearoldsexuallyactivemalepresentstohisprimarycarephysicianwithpainful urinationand urethraldischarge. Gramstainof discharge fluidshows gramnegative diplococci. He is given Ceftriaxone for gonococcal infection. What additional medicationshouldhebegiven? 

Aztreonam Doxycycline Imipenem/cilastatin Nitrofurantoin

Question92[1.00pt(s)] Productssuchaspsyllium,methylcellulose,andpolycarbophilareknownas: 

Stimulantlaxatives Bulkformingagents Cathartics Lubricants

Question93[1.00pt(s)] Benzodiazepinesactataspecificreceptorsite: 

GABAergic Serotoninergic Dopaminergic Muscarinic

Question94[1.00pt(s)] WhatisthemechanismofactionofamphotericinB? 

Bindsergosterol Inhibitscellwallsynthesis InhibitsDNAsynthesis Inhibitssqualeneepoxidase

Question95[1.00pt(s)] Thebenzodiazepines’ action dependsontheir interactionwithwhichofthe following receptors? 

NMDAglutamate Dopamine

Question96[1.00pt(s)] TGisa43yearoldwomanwhopresentswitha2weekhistoryofepigastricpainand a positive serum antibody for H. pylori. Which of the following would be considered thepreferredinitialtherapyforH.pylori? 

PPI+metronidazole+levofloxacin PPI+amoxicillin+levofloxacin PPI+amoxicillin+clarithromycin PPI+metronidazole+bismuth+tetracycline

Question97[1.00pt(s)] Whichofthefollowingisinvolvedinmetronidazole’saction? 

Blockingfolicacidsynthesis DisruptionofDNA Inhibitionofribosomes Inhibitionoftopoisomerase

Question98[1.00pt(s)] Neuropathicpainrespondswellto: 

Opiates NSAIDs Paracetamol Antiepileptics

Question99[1.00pt(s)] Anantiparkinsonianagentwhichactsdirectlyonthedopaminereceptoris: 

Levodopa Amantadine Selegiline Bromocriptine

Question100[1.00pt(s)] Localadverseeffectsofinhaledcorticosteroidsinclude: 

Oralcandidiasis

Question101[1.00pt(s)] Opioidreceptorsmostlyinvolvedinpainare: 

Mureceptors Kappareceptors Yreceptors Omega3receptors

Question102[1.00pt(s)] A23yearoldwomanwhounderwentanopenappendectomyislaterfoundtohavea woundinfection.AculturegrowsmethicillinresistantStaphylococcusaure...