Fidaxomicin - Wikipedia PDF

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Summary

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Description

Fidaxomicin Fidaxomicin (trade names Dificid, Dificlir, and previously OPT-80 and PAR-101) is the first member of a class of narrow spectrum macrocyclic antibiotic drugs called Tiacumicins.[2] It is a fermentation product obtained from the actinomycete Dactylosporangium aurantiacum subspecies hamdenesis.[3][4] Fidaxomicin is minimally absorbed into the bloodstream when taken orally, is

bactericidal, and selectively eradicates pathogenic Clostridium difficile with relatively little disruption to the multiple species of bacteria that make up the normal, healthy intestinal flora. The maintenance of normal physiological conditions in the colon may reduce the probability of recurrence of Clostridium difficile infection.[5][6]

Fidaxomicin

Clinical data Trade names

Dificid, Dificlir

Other names

Clostomicin B1, lipiarmicin, lipiarmycin, lipiarmycin A3, OPT 80, PAR 01, PAR 101, tiacumicin B

AHFS/Drugs.com License data

Monograph EUEMA:by INN USDailyMed:Fidaxomicin USFDA:Fidaxomicin

Pregnancy

AU: B1

category

US: B (No risk in nonhuman studies)

Routes of administration

Oral

ATC code

A07AA12 (WHO ) Legal status

Legal status

AU: S4 (Prescription only) CA: ℞-only UK: POM (Prescription only) US: ℞-only

Pharmacokinetic data Bioavailability

Minimal systemic

absorption[1] Elimination half-life

11.7 ± 4.80 hours[1]

Excretion

Urine (...