Haemophillus, Legionella & Bordetella PDF

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summary of Haemophillus, Legionella & Bordetella. Microbiology...

Description

Haemophilius infuenzae pertussisBordetellamophilia Legionella

ABOUT - Pleomorphic -ve bac/coccobacilli - Facultatively anaerobic (max growth in 5% CO2) - Man only (colonise nasopharynx of healthy5% capsule, 25-80% NC) - Transmitted via respiratory - H ducreyi: chancroid (STI) - No-capsule -ve bacillus - Strict aerobe - 50 species, >70 seroG - Ubiquitous organism AQUATIC BODIES: 35-42oC, stagnation, scale, sediment - Tiny -ve coccobacillus - 3 distinct serotypes 1-3 - Human specific organism - Strictly aerobic - Highly infections - Attach to ciliated resp epith in nasopharynx & PREVENTION OF PERTUSSIS

VIRULENCE 1. Capsule: 6 types- Severe invasive disease. 2. Capsule type b/ Hib: systemic disease: anti-phagocytic PS capsule- polyriboxyl ribitol phosphate (PRP). No anti-PRP Ab helps evade IS 3. Attatchment pilli & fimbriae 4. IgA1 protease TOXINS: - No exotoxins 1. Motile (fimbriae, fagellum) 2. Haemolysin - Causes 85% of human infections with the species- esp serogroup 1

CLINICAL ENCAPSULATED H. infuenzae (type B) 1. RTI in early childhood: acute epiglottitis, pneumonia 2. Meningitis: mort 90% untreated, sequelae: deafness, seizures, intellectual impairment 3. Septic arthritis esp in infants 4. Sepsis often with meningitis 5. Cellulitis: closed, spreading - VACCINE PREVENTABLE (purified cap PS conjugated w/ P carrier. 2, 4, 6 mo; booster at 13 mo) - Severe in...