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Metabolic Pathways O CHOH AcNH

2

CO O-

CHOH

O

O COO-

6.3.2.7-10 6.3.2.13 HO O

2.4.99.7

CH 2 OH

OPC

OPPU

CH 3CH

CMP-N-Acetyl neuraminate

CH2 OH OCOO HO

O

CHOH CHOH

OH OH

1.1.1.158

2.7.7.43 3.1.3.29

UDP-N-AcGalactosamine

OPPU NHAC

O

UDP-N-AcGlucosamine pyruvate N-Ac-Mannosamine-6-P CH 2OH O

HO OH

HO OH

HO OH

OPPU

5.1.3.14

UDP-N-Ac-Glucosamine

OP

OH

HOCH 2

C

C

C

C

H

OH H

H

OH H C

OH

Glucuronate

OH OH

C

C

H

HOCH 2

CO

Gulonolactone1.1.3.8 OH H HOCH 2 C

CO

H

3-Dehydrogulonate H

OH HOCH 2

C H

C

HOCH 2 C

HOCH 2

H

C

C

H

OH OH

2

C

C

C

H

H

OH

CHO

OH

HOCH 2 C

H

H

C

H

C

HOCH 2

1.1.1.10

CO

H

OH H

C

C

CHO

HOCH 2

C

C

H

H

HOCH 2

C CH 2OH OH

C

H

OH

1.1.1

H

OH H

C

C

.9

2H+

C

H

H

2PQH 2

POCH 2

H

H

H

C

C

C

C

C

P OCH 2 H OH

5.3.1.6 .1.1

4.1.2.-

H

H

HO

C

C

C

CO

D-Xylulose-5-P

C

C

CHO

POCH 2

OH OH OH

H

H

H OH

C

C

C

NH 2

C CO CH OP 2

Glyoxylate

4H+

H+ H+ H+ H+ H+ H+ H+ H+ H+ H+ H+ H+

ADP

H+

THYLAKOI D ME MBRANE

ATP

ATP synt hase

HO

ADP

SERINE

4.2.1.22

- OOC NH 2 OC

POCH CH(N+H )COO 2 3

1.14.99.25 1.1

1.3.1.35

L I P I D

COSCoA

4.9

CO-S-ACP

9.1

3

COO

Prostaglandin PGE 2

H

Palmitoyl-ACP ACYL-ACP

2, 3-Enoyl-ACP

Decanoyl-ACP

CH 3(CH 2) 2CH 2CH 2COSACP

CH (CH ) CH=CHCO-S-ACP

1.3.1.9

Hexanoyl-ACP

3

CH3 (CH2 )2 CH(OH)CH 2COSACP

4.2.1.59

2 2

2, 3-Hexenoyl-ACP

1.1.1.100

3-OH-Hexanoyl-ACP CH 3CH(OH)CH 2COS-ACP

4.2.1.58

Crotonoyl-ACP

3-OH-Butanoyl-ACP

6.2.1.3

3-Oxoacyl-ACP

CH (CH )2 COCH COSACP 3 2 2

2.3.1.15

CH O-CO-R

2.3.1.39

FAT

CH2 O P

2

2.3.1.20

Diacyl glycerol

4.1.1.4

R’-CO-OCH

CH OH

Triacylglycerol 3.1.1.28

CH3 CH(OH)CH2 COO

3.1.3.4 2.7.1.107

1.1.1.30

CH3 COCH2 COO

3.1.2.11

ACYL-CoA

1.3.99.3

(Mitochondria)

CH 3(CH 2) CH CH COSCoA 2 2 2

Hexanoyl-CoA

1.3.99.3

CH 3CH 2CH 2COSCoA

1.3.99.2

Butanoyl-CoA

2, 3-Enoyl-CoA CH3 (CH2) 2CH=CHCOSCoA

2, 3-Hexenoyl-CoA CH3 CH=CHCOSCoA

Crotonoyl-CoA

4.2.1.17

CH(OH)CH COSCoA n 2

3-OH-Acyl-CoA

)2 CH(OH)CH COSCoA 3 2 2 4.2.1.17 CH (CH

3-OH-Hexanoyl-CoA

4.2.1.55

CH 3 CH(OH)CH2 COSCoA

1.1.1.35

3-Oxoacyl-CoA

1.1.1.35

CH3 (CH2 )2COCH 2COSCoA

CH COCH COSCoA 3 2

CH3 CH2CH(OH)CH 2COSCoA

CH 3CH 2CH=CHCOSCoA

Pentanoyl-CoA

1.1.1.35

PYRUVATE

ALANINE

4.1.3. 18

1.1

R '-CO-OCH O

3-OH-Pentanoyl-CoA

Pentenoyl-CoA CH O-CO-R

OH

-

O

R '-CO-OCH

1.3.99.7

3-Oxopentanoyl-CoA

4.1.1.65

O + NH3 CH O 2 P OCH 2CH 2 O

-

2

2

-

3

O

PHOSPHATIDYL SERINE CH 2O-CO-R R '-CO-OCH O

O HCO-CO-R

CH 2O-PO CH2 CH(OH)CH2 O-P-OCH 2 O O

CPP- OCH CH

2.7.8.1

Serine

2.7.8.8

2

-

NH3

HOCH COO 2

Glycolate 1.2.1.21

CH2O-CO-R R' -CO-OCH

2.7.8.5

O

CH2O-PO CH2 CHOHCH 2OH

OPhosphatidylglycerol

+

2

1.2.3.5

O

CDP-diacyl glycerol

4.1.3.5

POCH CH

2.7.7.14

2

+ 2

NH3

2.7.1.82

CH3 C(OH)CH2 COSCoA

ß-OH-ß-Methylglutaryl-CoA

HOOC-COOH

Oxalate

1.1.1.34

HOCH 2CHO

Glycol aldehyde 1.4.3.8

4.2

HOH GDP CO2

NAD+

+ HOCH CH 2 2 NH

NADH+H+

Mevaldate

CYSTE

1.13.11.20

Cysteine sulphinate

3

.5

2

3

THREONINE 4.1.3. 18

OHCCH2COO-

Malonic semialdehyde

POCH 2 CH 2 CH(N

4.2.99.2

O-Phos homose COO

4.2.1.16

CH COC(OH)CH 3

2-Acetolact CH3 CH2 COCOO

Oxobutyrate

4.1.1.32

CH3

GT P

4.1 CH 3

HOCH CHCO 2

.3.1

8

OHCCHCOO

Methylmalonyl semialdehyde

31 1.1.1.

3-Hydro isobutyr COO CH 3COC(OH)CH CH 2

-OOCCOCH COO2

OXALOACETATE

2.6.1.1

2-Aceto-2hydroxy- 1.1 butyrate

2.3.1. 16

4.1.3.7

NAD+

4.2.1. 18

4.1.3.8

CH 2COO-

CH 3

C(OH)COOCH 2COO-

CH3 COCHCOSC

2-Methylace acetyl-CoA

CITRATE

I

4.1.3.2

4.2.1.3

-OOCCHO

1.1.1.37

Glyoxylate Cycle

FMNH2 +

2H

1.8

.8 HSCH CH(NH 2

4.1.1.2

1.1.1.39

4.1.3.4

FMN

.1

1.2.1.18

ACETYL- CoA

I CH2 COO CH 3C(OH)CH CHO 2

1.6.4.1

+ CH CH(OH)CH(NH )COO

3

6.4.1.1

CH 2COO

1.1.1.79

CYSTINE

.99

4.1.2.5

2.6.1.18

7

LACTATE

NADH+H+

4.1.3.5

Glyoxylate

2.7.7.41

CH 2O POCMP

Inositol

2.7.8.11 CH 2O-CO-R’

Cardiolipin

O

R'-CO-OCH

OHCCOO

4.2

4.1.1.12

CH CH(OH)COO

1.2.4.1 2.3.1.12 3.1.3.43

2.3.1.9

Acetoacetyl-CoA

1.6.5.3

CH O-CO-R 2 R' -CO-OCH

COO O + CH O PO CH CHNH

HO OH OH

Phosphatidyl inositol

CH 2O-CO-R

2

OH

CH 2 O-PO

.1.2

CH 3COCOO-

NAD AT P CO2

HS

+ S-CH2 CH(NH 3)COO + S-CH2 CH(NH 3)COO

3-Sulphinyl pyruvate

+ CH 3CH(NH3 )COO

2.6.1.2

4.1.1.9

.1.44 2.6.1.4 2.6 CH 2 O-CO-R

+ CH 2CO-OCH CH(NH )COO 2 3

HSO3-

1.4.1.1

1.2.4.1 2.3.1.12 1.8.1.4

Malonyl-Co-A

2.3.1. 16

CH3 CH2 COCH 2COSCoA

0

+ HO2SCH 2CH(NH 3 )COO

CH 3 COSCoA

CH3 CH2 CH2CH 2COSCoA

.1.3

HO 2SCH COCOO 2

CH 3CO-S-ACP

2.3.1. 16

3-Oxohexanoyl-CoA

1.1.1.157

3-OH-Butanoyl-CoA

Odd C Fatty acids

NH CH

4.3.1.3

CH 2CH 2NH 2

4.4.1.15

4.4.1.15

2.3.1.38

CH3 (CH2 )nCOCH 2COSCoA

2.3

.1.1

Acetyl-ACP

Acetoacetate

Phosphatidate

4.1

PYRUVATE CH (CH 3

2.1.3.2

3

ATP

.1.2

CH 3(CH 2) nCH 2CH COSCoA 2 CH 3(CH 2) nCH=CHCOSCoA

C

N

HISTAMINE

2.7.1.40

3.7

HOOCCH 2CO-SCoA

2.7.8.5

2

R’-CO-OCH

CH2 O-CO-R"

O-Acyl-carnitine

Malonyl-ACP

KETONE BODIES CH 3COCH 3

HC

NH C H

HS

2.3.1.41

3-P-Glycerol

2.3.1.51

CH 2 O-CO-R

R’-CO-OCH

Acetaldehyde

ADP

2

2.7.1.30

P-enolpyruvate

HOOCCH 2CO-S-ACP

Acetone3-OH-Butyrate

CH2 O-CO-R

3.1.1.3

Acetoacetyl-ACP

N

HISTIDIN

Acetylserine

CH CHO

2.3.1.41

2.3.1.7

Carnitine O-Acyl-carnitine

ETHANOL

CH 2=C(O P) COO

CH3COCH 2COSACP

1.1.1.100

C

N

CH 3CH 2OH

CH OP

2

Glycerol

NHCOCH 2CH 2NH 2

Carnosine

C

N

1.1.1.1

3-Oxo-Hexanoyl-ACP

1.1.1.8

HOCH

HOCH CH OH

FATTY ACID

3.1.2.20

CH 2OH

CH2 OH

R-CH 2COO CH3 (CH2 ) n + 2COS-CoA

HC

1.2.1.4

3-Oxo-Decanoyl-ACP

3

CH 3CH=CHCO-S-ACP

1.3.1.9

NH 2 N +C N C HC

4.1.1.22

HOCH2CH(O P) COO

2-P-Glycerate

2.3.1.41

CH CH=CHCO.S-ACP

CH 3CH 2CH 2COSACP

Butanoyl-ACP

ACYL-CoA (Cytosol)

P H O

C H

CH 3(CH 2) 6COCH 2COSACP

1.1.1.100

60 4.2.1.

2, 3-Decenoyl-ACP

C

ACETATE

Mit ochondrial

3-OH-Decanoyl-ACP

CH (CH ) CH=CHCOSACP 3 2 6

NH

Glycerate

2.3.1.41

CH3 (CH2 ) 6CH(OH)CH2 COSACP

C

CH COO

CH (CH )2 n COCH2COSACP 3

1.1.1.100

3-OH-Acyl-ACP

4.2.1. 60

3, 4-Decenoyl-ACP

1.3.1. 9

C

C CH2 CHCOO

N

HOCH 2 CH(OH)COO COO

4.2.1.11

CH3 (CH2 )5CH=CHCH COSACP 2 CH 3(CH 2) 6CH 2CH 2COSACP

CH3 (CH2) n CH(OH)CH 2COSACP

4.2.1.60 4.2.1.61

H

3

Chain e longat ion

Palmitoyl-CoA CH 3(CH 2) n CH=CHCOS-CoA

1.3.1.9 1.3.1.10

H

P-Ribosyl-ATP 3.6.1.31P-Rib HC

POCH 2CH(O P) COO

2, 3-Diphospho-5.4.2.1 glycerate

Oxostearoyl-CoA

H

OH OH O

2.4.2.17

Endoplasmic Reticulum CH 3(CH 2) 14COSCoA

CH ) COS-ACP 3 (CH 2 14

D E G R A D A T I O N

Thromboxane B2

CH 3(CH 2 ) 14COCH 2COS-CoA

OH-Stearoyl-CoA

P OCH 2 C

P OCH COCOO 2

P-Hydroxypyruvate

2.7.1.31

OH

3.5.2.3

2.6.1.22

2.6.1.52

CH3 (CH2 )14 COCH2 COS-CoA

B I O S Y N T H E S I S

L I P I D

5.3.99.5

CH 3(CH 2) 14CH(OH)CH 2COS COS-CoA

2 14

Dehydrostearoyl-CoA

O

HO

OH

CH-COO

H

1.1.1.29

1.1.1.95

3-P-Glycerate

COO

.3 HO

CH (CH ) CH=CHCOS-CoA

COSCoA

Stearoyl-CoA

POCH2CHOH COO

OH

O

.99

Palmitoleoyl-ACP

Oleoyl-CoA

1.14.99.5

5.3

2

Carbam ß-alan

CH 2

Carbamoyl aspartate

Phosphoserine

ATP

1.13.11.34

COO

N

2

3.5.1.6

ß-Alanine 3.1.3.3

3.5.

H NCONHCH CH

H 2NCH2 CH 2COO

COO

Linoleate

3.5.1.6 ß-Ureido isobutyrate 2.1 .1.1 3

3-Aminoisobutyrate 4.1.1.11

Hydroxypyruvate

ADP

COO

H 2 NCH2 CHCOO

+

2.7.7.6

CH 3 H 2NCONHCH 2CHCOO

CH 3

HOCH 2COCOO

.7

20 4.2.1.

4.1.2.5

HOCH2CH(NH3 )COO

2.6.1.51 1.4.1.7

OH OH

P-Ribosyl-PP

OH

2.7.4.6

ATP

FOLIC ACID C1 POOL

2.1.2.1 3

CHOLINE

1:3-bis-P-Glycerate

OP OP

O

2.7.7

1.1.99.1

2.7.2.3 HO

O

ATP

4.6.1.1

2.7.4.6

+ HOCH 2CH 2N (CH3) 3

POCH 2CHOHCOOP

NH

d-ADP

+

Betaine aldehyde

1.7.3

d-ATP

1.2.1.8 OHCCH 2N(CH 3)

6.3.4.7 Pi NAD+

1.2.1.12

CHLOROPLAST OUTE R ME MBRANE

COO

O

OH

Cyclic AMP

Betaine

Pi

.1 5.3.1 2.7.1.28

3.6.1.34

STROMA

O

Dimethylglycine

NADH 2.7.6.1

CH2 O

2.1.1.5

CH2 OP O

Fixation

AT P

O

Allantoin

N O O HC O - P~ OP ~O P O CHN O 2

CH

N

OOCCH 2N(CH 3)2

2.4.2.14

H+

THYLAKOI D LUME N

3.5.2.5

N

HC N

CO C N H NH H

3

Sarcosine

3-P-Glyceraldehyde

.1

N

NH

OC

OC

NH

1.4.4.2

1.2.1.13

CO2

AT P

H+

5.3.1

Ribulose-1,5-bis-P

H+

H+

NH 2

N

1.5.99.2

4.1.2.13

Glyceraldehyde

Pi

H+

H+ H+

H+ H+

C H

N H

+

(Glyce rone - P)

ADP

Pi

OC

H 2N

COO NH 2 CO

H2N

Allantoate

O

2.1 OOCCH NHCH 2

CH

H 2N C RP

OOCCH2 N(CH3 )3

2.2.1.1 Dihydroxyacetone-P

NADPH+H+ H+ H+

Formyl glycinamide-R P

O P

N

HC

CHO NH

Formyl 6.3.3.1 5-Amino glycinamidine-R P imidazole-

6.3.5.3

+

OH OH OH H

HOCH 2COCH 2OP

NADP+

HN C

RP

GLYCINE

2.2.1.1

H+ H+

H+

NH H 2C

CHO

NH

.1.4 2.6 0 .1.1 .20 1.4 .1

Sedoheptulose-PP

H+

P700

NH H C

Urea

P-Ribosyl amine

H

D-Ribose-5-P

H+

2

2.1.2.2

CH 2(NH 3)COOH

CH 2O P O

OH OH H

POCH 2 C

2

H 2NCONH 2

CH2 OP

Fructose1:6-bis-P

2.2.1.2

OH H

5

NHCOCH NH

6.3.4.13

OH OH H

C CO CH 2OH

2.7.1.17

Chl.A 0 PC

H+

C

POCH 2

D Plastoquinone

4-OH-3-Methoxyphenylglycol

2

ADP

(Vitamin E)

2

OCH 3

3.5.3.4

OH OH OH

5.1.3.4

CHOHCH OH

Erythrose-4-P

5.1.3.1

CHO

Dopamine

OH

2.7.1.11 3.1.3.11

C CHO

OH OH

D-Ribose

H+

Fe-S 2e- Cyt.f

H+ H+Protons from Water

H

H

OH OH

1.14.17.1

.1.6

(Normetadrenaline)

OC

ATP

CO CH 2OH

POCH 2 C

2.1

H

1.3.1.13

(Noradrenaline)

CHOHCH NH 2 2

C CO CH 2OH

Glycinamideribosyl-P

1.13.11.27

OH

.3.4

OH OH

Shikim

CH2 CH2 NH

Norepinephrine

OCH OCH 33 OH

1.4

CH OP 2 O

HO

C

Fructose-6-P

OH OH H

CH 2OH

CO

H

C

POCH 2CHOHCHO

.

2e-

H+ H+

O2

CH 2OH

2.7

Fe-S

T ranslocated protons H+

H+

C

OH

PC PC

H+

C

HOCH 2

A1

Cyt bc _ 2e2PQ 2PQ

Mn

H2O

C

OH

OH OH H

NADPH

5.1.3.1

Ribitol

CO CH OH 2

PQ

1e-

Cyt bf

2e-

H

PHOTO- H+

2e-

P680 Chl.a

H

POCH 2

OH

OH

2.1.1.28

4-OH-3-MethoxyD-mandelate

H H
...