MICR3305 Unit Guide PDF

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FACULTY OF HEALTH AND MEDICAL SCIENCES SCHOOL OF BIOMEDICAL SCIENCES

MICR3305 Immunobiology and Immune Diseases

Semester 1, 2020 Crawley Campus

Unit Coordinators: Assoc/Prof Allison Imrie Dr Calila Santos

All material reproduced herein has been copied in accordance with and pursuant to a statutory licence administered by Copyright Agency Limited (CAL), granted to the University of Western Australia pursuant to Part VB of the Copyright Act 1968 (Cth). Copying of this material by students, except for fair dealing purposes under the Copyright Act, is prohibited. For the purposes of this fair dealing exception, students should be aware that the rule allowing copying, for fair dealing purposes, of 10% of the work, or one chapter/article, applies to the original work from which the excerpt in this course material was taken, and not to the course material itself.

© The University of Western Australia 2020

CONTENTS Unit description Unit description and content Learning outcomes

1 1

Contact details Unit coordinators Academic teaching staff Scientific Officers Contacting academic and professional staff by email

2 2 2 2

Unit contact hours

3

Assessment mechanism Assessment mechanism summary Assessment details Practical requirements Appeals against academic assessment

3 3 3 4

Ethical scholarship, academic literacy and academic misconduct

4

Charter of student rights and responsibilities

5

Student guild contact details

5

Student feedback

5

Unit resources Learning Management System (LMS) Textbooks and resources

6 6

Unit schedule Lectures Laboratory and Tutorial Sessions Mid-Semester Tests and Final Examination

7 8 9

UNIT DESCRIPTION Content This unit builds upon basic concepts of immunology taught at Level 2. It focuses on human immune responses and expands on the basic concepts of innate and adaptive immunity; effector cells and cytokines; the complement system; mucosal immunity; generation of diversity in adaptive immune responses; the structural and molecular basis of antigen recognition including the major histocompatibility complex; mechanisms of immune control of pathogens. This unit also discuss the importance of the immune response in transplantation and organ rejection, in autoimmune diseases and tumour biology. In addition, it addresses the immunobiological basis of vaccination and the design of new immunotherapeutics. Tutorials and workshops will address methods and approaches used to investigate immune responses in the context of infectious disease, vaccination, and immunopathogenesis. Laboratory classes are undertaken to reinforce the material taught in lectures. Students will work in groups to produce a short video on a vaccine-related topic. Learning outcomes Assessment Activity

Outcomes Students will be able to recall and integrate key knowledge and concepts about: • • • • • • • • • • • •

Structure and function of the major effector cells of the immune system Innate immunity Adaptive immunity – humoral and cell-mediated Diversity in antigen recognition How antigens are presented and the outcomes thereof Regulation of host immune responses Timing and progression of immune responses Role of the immune response in prevention and control of infectious diseases Microbial immune evasion strategies Immunopathological basis of autoimmunity Immunopathological basis of asthma and allergy Immunobiological basis of vaccination and immunotherapeutics

Students will acquire skills in: • • • • • • •

Laboratory safety and risk assessment Identifying the parts of the microscope Differential white blood cell counts Blood typing Immunohistochemistry Serology for detection of anti-microbial antibody, vaccination and allergic responses Basics of flow cytometry and other approaches for measurement of immune responses

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These learning outcomes will be assessed in the following ways: (1) final examination; (2) quizzes; (3) group assignment

These learning outcomes will be assessed in the following ways: (1) final examination; (2) quizzes; (3) tutorials/workshops

CONTACT DETAILS Unit coordinators Associate Professor Allison Imrie [email protected] Dr Calila S. Santos [email protected] Academic teaching staff Assoc/Prof Allison Imrie [email protected] Assoc/Prof Manfred Beilharz [email protected] Dr Calila S. Santos [email protected] Scientific Officers Julia Dymond [email protected] Nathan Selten [email protected] Contacting academic and professional staff by email Queries regarding timetables and schedules are to be directed to Administrative Officer Alexandra Lowe; [email protected] All queries and applications for Special Consideration (required when a student cannot attend a compulsory class) are to be directed to your Faculty adviser. All LMS-related issues, including problems relating to access to the LMS and access to lecture recordings, should be directed to Student LMS Help. All email messages, should you need to contact a lecturer directly, should be polite, considerate, and contain correct grammar and spelling. All should begin with an appropriate salutation, e.g. “Dear…”, and end with a suitable closing, e.g. “Regards…”. Writing a professional email is a generic skill that you should acquire while at UWA. Do not expect an answer to an email outside of business hours (Monday – Friday, 9.00 – 17.00) or to receive an answer on the same day. Please check the “Announcement” section in the unit’s LMS page before sending an email. Your question may have already been addressed. IMPORTANT: Always include the Unit Code MICR3305 in the email header. We receive *many* emails each day and your message can be lost.

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UNIT CONTACT HOURS Times vary according to the University Timetable. 2 lectures per week; 6 (mandatory) x 3hr laboratory sessions from the start of semester; 9 (mandatory) x 1hr tutorial sessions. Other tutorials may be scheduled during the course of the semester. Schedule clashes If you have a schedule clash for any compulsory class (e.g. Laboratory or Tutorial) contact the Administrative Officer Alexandra Lowe [email protected] before the due date, and alternative arrangements will be considered.

ASSESSMENT MECHANISM SUMMARY 1. Final examination; 60% 2. Mid-semester tests; 35% 3. Assignment; 5% Assessment details Satisfactory performance in both the practical and theory components of the unit is required to pass the unit. Completion of the practical requirements (attendance and all assessment tasks) is compulsory. Attendance is required at all laboratory sessions and tutorials for satisfactory completion of the unit. To avoid a mark penalty, if an assessment task is missed due to illness or another unforeseeable cause, special consideration will need to be granted by the Student Office of the Faculty of Health and Medical Sciences. Applications for special consideration must be submitted no later than three University working days after the date of the missed session. For details go to: http://www.student.uwa.edu.au/course/exams/consideration IMPORTANT: If a session is missed without approval, the assessment for that lab/ tutorial cannot be undertaken.

Laboratory Class Requirements You are required to satisfactorily complete all practical sessions. Suitable attire (laboratory coat, CLOSED shoes and long hair tied back) must be worn to all lab sessions. You should keep accurate lab notes during all lab sessions as these will assist you with your learning. You do not need to purchase a notebook for your laboratory notes and can use the Laboratory Manual. Please always act in a sensible fashion when undertaking any experimental procedure. Handle all chemicals and tissue samples with care, and wear gloves at all times. If you do not adhere to safety rules, you will be removed from the laboratory.

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You cannot bring your own calculator into the laboratories; when one is needed during a class it will be provided for you. Please note that any calculators used in the final exam at UWA MUST be authorised by Student Administration and labelled with an approval sticker. If your calculator does not have this sticker you will NOT be allowed to use it for any assessment. Appeals against academic assessment If students feel they have been unfairly assessed, they have the right to appeal their mark by submitting an Appeal Against Academic Assessment form to the Head of School and Faculty Office. The form must be submitted within twenty working days of the release of the formal result. It is recommended that students contact the Guild Education Officers to aid them in the appeals process ([email protected]). Full regulations governing appeals procedures are available from Academic Policy Services (Review and Appeal of Academic Decisions Relating to Students).

ETHICAL SCHOLARSHIP, ACADEMIC LITERACY AND ACADEMIC MISCONDUCT Ethical scholarship is the pursuit of scholarly enquiry marked by honesty and integrity.

Academic literacy is the capacity to undertake study and research, and to communicate findings and knowledge, in a manner appropriate to the particular disciplinary conventions and scholarly standards expected at university level. Academic misconduct is any activity or practice engaged in by a student that breaches explicit guidelines relating to the production of work for assessment, in a manner that compromises or defeats the purpose of that assessment. Students must not engage in academic misconduct. Any such activity undermines an ethos of ethical scholarship. Academic misconduct includes, but is not limited to cheating, or attempting to cheat, through: • • • • • •

Collusion Inappropriate collaboration Plagiarism Misrepresenting or fabricating data or results or other assessable work Inappropriate electronic data sourcing/collection Breaching rules specified for the conduct of examinations in a way that may compromise or defeat the purposes of assessment.

Penalties for academic misconduct vary according to seriousness of the case, and may include the requirement to do further work or repeat work; deduction of marks; the award of zero marks for the assessment; failure of one or more units; suspension from a course of study; exclusion from the University, non4

conferral of a degree, diploma or other award to which the student would otherwise have been entitled. Refer to the Ethical Scholarship, Academic Literacy and Academic Misconduct policy.

CHARTER OF STUDENT RIGHTS AND RESPONSIBILITIES This Charter of Student Rights and Responsibilities upholds the fundamental rights of students who undertake their education at the University of Western Australia. It recognises that excellence in teaching and learning requires students to be active participants in their educational experience. It upholds the ethos that in addition to the University's role of awarding formal academic qualifications to students, the University must strive to instil in all students independent scholarly learning, critical judgement, academic integrity and ethical sensitivity. Please refer to the website the full charter of student rights and responsibilities, located at http://www.secretariat.uwa.edu.au/home/policies/charter

STUDENT GUILD CONTACT DETAILS The University of Western Australia Student Guild 35 Stirling Highway Crawley WA 6009 Phone: (+61 8) 6488 2295 Facsimile: (+61 8) 6488 1041 E-mail: [email protected]. Website: http://www.uwastudentguild.com/

STUDENT FEEDBACK In the course of the unit you will be asked to complete the following surveys: • Students' Unit Reflective Feedback (SURF) • Student Perceptions of Teaching (SPOT). The feedback you provide in the SURF is used by the unit coordinator to modify future delivery and content of the unit, ensuring high quality teaching and learning practices at UWA. Your responses on SPOT questionnaires are used by the lecturing and demonstrating staff to develop their individual teaching approaches, unit content and student engagement methods. It may also be used to support excellence in teaching and promotion applications. We value your feedback!

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UNIT RESOURCES Learning Management System All course materials, including lecture handouts, tutorial information, and notices about the unit will be posted on the Blackboard Learning Management System in MICR3305: Immunobiology and Immune Diseases. For assistance with the LMS, do not contact the unit coordinator. On the LMS site, select the “LMS Help: STUDENTS” link at www.lms.uwa.edu.au or contact SISO at [email protected] or 6488 3814 or in person at the Reid Library and the Science Library. Or, browse answers online anytime or ask a question through askUWA available at: http://ipoint.uwa.edu.au Lecture Capture UWA’s Lecture Capture System (powered by EchoSystem) captures lectures in selected venues and publishes them in Learning Management System (LMS). MICR3305 lectures will be captured as audio and screen capture and will be published in LMS and available for streaming. We strongly recommend that you attend all lectures in the unit and use the lecture capture system as a backup. We cannot guarantee that all lectures will be captured as the system does fail from time to time.

Textbooks and resources Recommended textbooks are available in UWA Libraries and in some cases as eBooks: 1. Basic Immunology (6th Edition); Abbas, Lichtman and Pillai (Elsevier Saunders) 2. Cellular and Molecular Immunology (9th edition); Abbas, Lichtman, Pillai (Elsevier) 3. Janeway’s Immunobiology (9th Edition); Murphy and Weaver (Garland Science)

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IMMUNOBIOLOGY AND IMMUNE DISEASES: UNIT SCHEDULE Lectures Thurs 8 – 10 am FJ Clarke LT Week

Date

Topic

Lecturer

Week 1/9

27/2 27/2

Cells and Tissues of Immune System Induced responses of Innate Immunity

AI AI

Week 2/10

5/3 5/3

Cytokines and inflammation Complement system

AI AI

Week 3/11

12/3 12/3

T cell development and MHC T cell antigen capture and presentation

AI AI

Week 4/12

19/3 19/3

T cell effector function B cell development

AI AI

Week 5/13

26/3 26/3

B cell activation and antibody production Humoral immune responses

AI AI

Week 6/14

2/4 2/4

Vaccination Hypersensitivity

AI AI

Week 7/15

9/4 9/4

Tolerance and autoimmunity Immune responses to transplant and tumours

AI AI

Mid-Semester break Week 8/17

23/4 23/4

Mucosal immunity Immune responses to viruses

AI AI

Week 9/18

30/4 30/4

Immune responses to bacteria Immune responses to protozoa and fungi

CS CS

Week 10/19

7/5 7/5

Congenital and Acquired Immunodeficiency Aging and immunity

CS CS

Week 11/20

14/5 14/5

Neuroimmunology Immunomodulators

AI AI

Week 12/21

21/5 21/5

Immunotherapy New approaches in vaccination

AI AI

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Laboratory and Tutorial Sessions Laboratory sessions: Fridays 10 – 1 pm or 2 – 5 pm; QEII L-Block G15, G17, G22

Sem Week

Date

Topic

Week 2/10

Fri Mar 6

Cell counting and dilution calculations

Week 3/11

Fri Mar 13

Blood typing; and blood films and differential white cell counts

Week 4/12

Fri Mar 20

Immunohistochemistry – tonsilitis and Candida infection

Week 5/13

Fri Mar 27

Measles ELISA

Week 6/14

Fri Apr 3

Dust mite allergens and cytokines ELISA

Mid-semester break week of Monday April 13

Week 8/16

Fri Apr 24

Review and summative assessment

Attendance at Laboratory sessions is mandatory

Tutorial sessions: Tuesdays 1-2pm (M G19); Thursdays 12-1pm (MG17/G19) Week 1/9

Introduction to unit; Assignment

Week 2/10

Serology: Antigen and antibody profiles

Week 3/11

Toolbox-1

Week 4/12

Type I IFN and viral infection

Week 5/13

IFN-gamma Elispot

Week 6/14

Assignment Progress

Week 8/17

Toolbox-2

Week 9/18

Assignment Marking Guidance

Week 10/19

Review and summative assessment

Week 12/21

Unit Review and Unit Feedback

Attendance at Tutorial sessions is mandatory

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Tests and Final Examination Date/Item

Content

Format

Weight

Week 7/15 MCQ 1

Lectures 1-10; Labs 1-3; Tutorials 2-4

MCQ

20%

Lectures 11-18; Labs 4-5; Tutorials 5-7

MCQ

15%

Tues 7/4/20 11:30am or 13:00; G15

Week 11/20 MCQ 2 Fri 15/5/20 11:30am or 13:00; G15

Final exam TBA

Lectures 1-24; Labs and Tutorials

Week 9/18

Group Assignment

Final exam will be based on all lecture, lab and tutorial content

LMS – learning management system MCQ – multiple choice questions EMQ – extended multiple choice questions SAQ – short answer questions

9

MCQ/EMQ/SAQ

Video

60%

5%...