PEX-04-03 - Physio Ex 9.1 PDF

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Physio Ex 9.1...

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Name: Steffany A. Rivera Exercise 4: Endocrine System Physiology: Activity 3: Hormone Replacement Therapy Lab Report Pre-lab Quiz Results You have not completed the Pre-lab Quiz.

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Experiment Results Predict Question: Predict Question 1: What effect will the saline injections have on the control rat's vertebral bone density? Your answer : c. The saline injections will not change the rat's vertebral bone density (indicated by an unchanging T score). Predict Question 2: What effect will the estrogen injections have on the estrogen-treated rat's vertebral bone density? Your answer : a. The estrogen injections will increase the rat's vertebral bone density (indicated by a less-negative T score).

Predict Question 3: What effect will the calcitonin injections have on the calcitonin-treated rat's vertebral bone density? Your answer : b. The calcitonin injections will decrease the rat's vertebral bone density (indicated by a more-negative T score). Experiment Data: Rat

Elapsed Days

Saline injections

Estrogen injections

Control Estrogen Calcitonin

7 7 7

7 0 0

0 7 0

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Calcitonin injections 0 0 7

T score -2.83 -1.74 -2.10

Post-lab Quiz Results You scored 100% by answering 4 out of 4 questions correctly. 1. Saline injections were used in this experiment to measure the effect of You correctly answered: c. a placebo on bone density. 2. In the ovariectomized rats used in this experiment You correctly answered: d. osteoporosis was evident prior to the injections of estrogen. 3. Injection of calcitonin into an ovariectomized rat will You correctly answered: b. inhibit osteoclast activity and stimulate calcium uptake and deposition in long bones. 4. As the rat's bone density increases You correctly answered: a. the X-ray scanning assay reports a less-negative T-score.

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Review Sheet Results 1. Why were ovariectomized rats used in this experiment? How does the fact that the rats are ovariectomized explain their baseline T scores? Your answer: Since the rats had their ovaries removed there was no more production of estrogen which would make the baseline T scores more negative. 2. What effect did the administration of saline injections have on the control rat? How well did the results compare with your prediction? Your answer: The T-score is more negative that all the other ones because the rat was already not producing any estrogen which then shows that the rat's bone density was already decreasing. 3. What effect did the administration of estrogen injections have on the estrogen-treated rat? How well did the results compare with your prediction? Your answer: It improved the T-scores because the production of estrogen helps increase the bone density. The T score was less negative. 4. What effect did the administration of calcitonin injections have on the calcitonin-treated rat? How well did the results compare with your prediction? Your answer: The T-score of the calcitonin treated rat is almost as low as the control rat because calcitonin activates osteoblasts for the removal of calcium from the bones to the bloood. The calcitonin injections decreased the rat's vertebral bone density. 5. What are some health risks that postmenopausal women must consider when contemplating estrogen hormone-replacement therapy? Your answer: The homeastasis migh be compromised and also there will be an increase in bone density.

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