PHA3042 Unit Guide 2018 PDF

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The guide contains information about the assessments and mark break down of each....

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Unit Guide 

PHA3042 Modern drug development Semester 2, 2018    Handbook link: http://monash.edu.au/pubs/2018handbooks/units/PHA3042.html Science Handbook link: http://monash.edu.au/pubs/2017handbooks/units/index-byfaculty-sci.html

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Table of contents Unit handbook information

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Synopsis

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Mode of delivery

4

Workload requirements

4

Unit relationships

4

Prerequisites

4

Prohibitions

4

Co-requisites

4

Chief Examiner(s)

4

Unit coordinator(s)

4

Lecturer(s)

5

Administrative contact Academic overview

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Learning outcomes

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Teaching approach

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Assessment summary

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Assessment requirements

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Participation

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Assessment tasks

13

Referencing requirements

19

Assignment submission

19

Returning assignments

20

Resubmission of assignments

20

Special Consideration

20

Extensions and penalties

20

Special Consideration Examination(s) Examination material or equipment Feedback to you

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Unit Schedule

24

Your feedback to us

26

Learning resources

26

Required resources

28

Technological requirements

28

Recommended resources

28

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Other information

29

Policies

29

Academic Integrity

29

Special Consideration

29

Clinical/Fieldwork Placement Procedures and Behaviour Guidelines

29

Word Count Guidelines

29

Honours Guidelines

29

Research Project and Minor Thesis Guidelines

29

Professional Editing Guidelines

29

Immunisation and Infection Risk

30

Police Checks

30

Working with Children Check Guidelines

30

Graduate Attributes Policy (within Course Design Policy)

30

Student Charter

30

Student Services

30

Monash University Library

30

Student Support

30

Disability Support Services

30

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Unit handbook information Synopsis Modern drug development will provide the student with an appreciation of the process of discovery, testing, approval and marketing of new drugs. This will include the diseases most likely to be targeted by pharmaceutical companies for drug development; the technical issues underlying drug discovery; the role of genomics in identifying novel targets; rational drug design; the importance of screens including molecular models and high throughput screening; disease models; case studies illustrating the successful development of drugs. Career opportunities in all aspects of drug development will be highlighted.

Mode of delivery Clayton (On-campus)

Workload requirements Two 1-hour lectures and three hours of laboratory or self-directed learning/ tutorial per week. Contact hours : Two 1-hour lectures and three hours of laboratory/workshop/self-directed learning per week (i.e. 5 hours/week) over the 12-week semester. Workload: In line with the University’s policy, the expected workload for this unit is 12 hours per week which equates to at least 7 hours of personal study in addition to the formal class contact.

Unit relationships Prerequisites PHA3011 and one of PHA3021, BMS3021 or BMS3031

Prohibitions None

Co-requisites None

Chief Examiner(s) Dr Barbara Kemp-Harper

Unit coordinator(s) 4

Dr Barbara Kemp-Harper Dr Eva Patak Unit Coordinators

Dr Barbara Kemp-Harper & Dr Eva Patak

Campus:

Clayton

Phone:

Dr. Kemp-Harper - 9905 4674 ; Dr. Patak - 9905 5783

Email:

[email protected]; [email protected]

Lecturer(s) Name: Name:DrBarbaraKemp-Harper Campus: Clayton Building: 9 Ancora Imparo WayRoom: 147 Phone: +61 3 990 54674 Email: Email:[email protected] Name: Name:DrEvaPatak Campus: Clayton Building: 27 Rainforest WalkRoom: 305 Phone: +61 3 990 55783 Email: Email:[email protected] Name: Name:DrJenniferIrvine Campus: Clayton Building: 9 Ancora Imparo WayRoom: EG20 Phone: + 61 3 990 55745 Email: Email:[email protected] Name: Name:DrJaneBourke Campus: Clayton Building: 13ERoom: 147 Phone: +61 3 990 55197 Email: Email:[email protected]

Name: Name:DrBradleyBroughton Campus: Clayton Building: 9 Ancora Imparo WayRoom: 139 Phone: +61 3 990 50915 Email: Email:[email protected] Name: Name:Dr RicDeGaris Campus: Biopharmaceutical Industry Consultant Building: Room:

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Phone: Email:

Name: Name:DrTraceyGaspari Campus: Clayton Building: 13ERoom: E119 Phone: +61 3 990 54762 Email: Email:[email protected] Name: Name:A/ProfJustinHamilton Campus: Alfred Hospital Building: Room: Phone: +61 3 990 30125 Email: Email:[email protected] Name: Name:MsJing JingLi Campus: Clayton Building: 75Room: 2103 Phone: +61 3 990 58153 Email: Email:[email protected] Name: Name:DrFrancineCoelho Marques Campus: Clayton Building: 17Room: G30E Phone: +61 3 990 56958 Email: Email:[email protected] Name: Name:MrSamMostafa Campus: MyDNA Life Building: Room: Phone: Email: Name: Name:DrRossMurdoch Campus: Phosphagenics Limited Building: Room: Phone: Email: Name: Name:Dr ShanePatella Campus: Pantheon Consulting Building: Room: Phone: Email:

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Name: Name:DrNataliePayne Campus: Australian Regenerative Medicine Institute, Monash University Building: Room: Phone: Email: Name: Name:DrHayleyRamshaw Campus: Clayton Building: 75Room: G86 Phone: +61 3 990 58906 Email: Email:[email protected] Name: Name:Assoc ProfessorChrishanSamuel Campus: Clayton Building: 9 Ancora Imparo WayRoom: 102 Phone: +61 3 990 20152 Email: Email:[email protected]

Name: Name:DrAnnieSolterbeck Campus: Statistical Revelations Building: Room: Phone: Email: Name: Name:A/ProfPaulWright Campus: School of Medical Sciences, RMIT University Building: Room: Phone: Email:

Administrative contact For administrative inquiries: Please contact Student Services in the School of Biomedical Sciences. In person: SOBS Reception, Ground Floor,23 Innovation Walk Online inquiry: viaask.monash.edu Phone inquiry: (03) 9902 6011

Academic overview Learning outcomes On completion of this unit students will be able to:

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1. Discuss the steps involved in the drug discovery process, including sources of drugs, how targets are identified and screening processes that can be used to test for desired activity; 2. Discuss the steps involved in developing a commercial product from a potential drug candidate, including the relevant regulatory framework and marketing considerations; 3. Critically evaluate methodologies and data from experiments in the context of the drug development process; 4. Obtain, present and interpret data from pharmacological experiments relevant to the area of drug development; 5. Source, integrate and critically evaluate the scientific literature to address an issue in the area of drug development and to communicate this orally, in written form or via a poster presentation; 6. Work both independently and as part of a team.

Teaching approach PHA3042: Modern Drug Development incorporates a number of teaching approaches. ●

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Pre-lecture activities will be provided to allow students to gain an overview of the lecture topic and/or set the context for the topic. Lectures will be used to provide an overview of material and to introduce, discuss and integrate key concepts in pharmacology and modern drug development. Laboratory-based practical classes will reinforce material covered in lectures and develop skills in interpretation of data, logical reasoning and scientific writing. In-class exercises will aid students to develop skills required to critically evaluate methodologies, approaches and study design, in the context of the drug development process. Group oral poster presentation will be used to develop skills required to source and critically evaluate the scientific literature, in the area of drug development, and to communicate this orally and via a poster presentation. Self- & Peer-marking sessions will help students develop skills required to critically evaluate their own and others’ work as well as engaging them in the assessment process. Workshopsand/or problem classes will be used to extend and apply knowledge and interpretation skills.

In 2018, some lectures in PHA3042 will adopt a “flipped” approach which will involve pre-class activities (e.g. videos, short readings, quizzes) to introduce concepts which will then be explored further and reinforced with in-class collaborative and interactive activities. Post-class activities (e. g. quizzes, follow up reading) will be used to help students consolidate and apply the concepts. This approach, along with timely assessment, aims to encourage the build-up of knowledge and understanding which is required to achieve a deeper level of learning to facilitate efficient “use” of knowledge. The relationship between the learning outcomes, teaching activities & assessment is outlined in the table below.

Learning Outcome

Teaching & learning activities

Assessment

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1. Discuss the steps involved in the drug discovery process, including sources of drugs, how targets are identified and screening processes that can be used to test for desired activity

lectures, practicals /workshops, self-directed learning

test; exam; practical reports

2. Discuss the steps involved in developing a commercial product from a potential drug candidate, including the relevant regulatory framework and marketing considerations

lectures, workshops, individual assignment, self-directed learning

test; exam; in-class activity; individual assignment

3. Critically evaluate methodologies and data from experiments in the context of the drug development process

lectures, practicals/workshops

test; exam; practical reports

4. Obtain, present and interpret data from pharmacological experiments relevant to the area of drug development

lectures, practicals/workshops

practical reports

5. Source, integrate and critically evaluate the scientific literature to address an issue in the area of drug development and to communicate this orally, in written form or via a poster presentation

workshops, final practical report, group assignment

final practical report; group assignment

6. Work both independently and as part of a team

individual assignment, group assignment, practicals/workshops

independent work: in-class activity; individual assignment; final practical report; test; exam team work: group assignment

From this table it can be seen that to demonstrate you have achieved all learning outcomes, you must satisfactorily complete all assessment tasks. For this reason: a pass (at least 45%) in the final examination, the practicals and in-class assessment component and the assignments must be obtained to pass the unit. 

Assessment summary Examination (3 hours): 50% (Hurdle) Tests: 10% Assignments: 15% (Hurdle) Practicals and in-class exercises: 25% (Hurdle) This unit is subject to the [[http://www.med.monash.edu.au/ policies/assessment-policy-2017.html][Hurdle and Threshold Standards policies]] of the Faculty of Medicine, Nursing & Health Sciences.

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Assessment task

Value

Due date

Practical Coursework and In-class Activities

25%

Various. Practical 1 worksheet to be completed in-class in Week 1. Practical 2 worksheet to be submitted at the start of your practical class in Week 3. Practical 3 worksheet to be submitted at the start of your practical class in Week 5. The Final Practical Report (incorporating data from practicals 1-4) is to be submitted online by 11.59pm Sunday September 16.

Assignments: Individual Sales Representative Presentation

7%

Presentation in allocated practical session on Thursday October 4 (Week 10)

Assignments: Group Oral Poster Presentation

8%

A mid-project update is to be provided to your mentor in your practical session in Week 9 (Thursday September 20). Display of poster and oral presentation in allocated practical session on Thursday October 18.

In-semester tests

10%

Ongoing (see Moodle and the Unit timetable)

Examination

50%

To be advised

Please note note: This unit is subject to the Faculty of Medicine, Nursing and Health Sciences Assessment policy as outlined below.

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Assessment requirements Students are required to note the Faculty’s assessment policy (item 1.2.1) regarding threshold standards/hurdles at: http://www.med.monash.edu.au/policies/assessment-policy-2017.html Students are required to refer to the University Academic Integritypolicy and procedure at: http://www.policy.monash.edu.au/policy-bank/academic/education/conduct/student-academic-integrity-policy.html The procedures state that: Proofreading: The process of identifying errors and suggesting corrections to a text. This must not involve rewriting passages of text in order to clarify meaning; amending the words used by the author (except to identify the correct spelling of the word used); rearranging passages of text or code, or reformatting other material; contributing additional material to the original; and checking calculations or formulae.

Academic Integrity and Technology In line with the Acceptable Use of Information Technology Facilities by Students Procedures, students are not permitted to use Information and Communications Technology facilities to sell, purchase or offer to write assignments or other assessable work, or to request help with such work. Furthermore, students are required to take steps to minimise opportunities for others to cheat by, for example, not saving work to a shared network drive that is accessible by others and not sharing work on social media sites. Failure to comply with these requirements may result in disciplinary action under Part 7 of the Monash University (Council) Regulations for collusion or general misconduct, as appropriate in the circumstances. Students should be aware that the University will monitor and act on information received about the use of cheat sites, paper mills and other online resources that promote dishonest academic conduct. If a student has been found to have used any of these sources to breach the Student Academic Integrity Policy, the University will pursue the matter in accordance with Part 7 of the Monash University (Council) Regulations.

Participation Practical work is considered an integral part of PHA3042 and attendance at ALL practical sessions (wet classes and workshops) is compulsory. Pre-practical exercises (see below) are to be completed online PRIOR to your allocated practical session. It is each student’s responsibility to check when these are due and the close-off time for their practical session (see Practical Guide). Lecture attendance is STRONGLY encouraged. While lecture attendance is not compulsory, it should be noted that class activities and discussions may not be fully recorded via the MULO recording system and therefore failure to attend a lecture may mean that you miss out on information that is covered in that class. Furthermore, completion of set pre-class activities is required to get the full benefit from each face-to-face teaching activity.

11 PHA3042 Modern drug development - Semester 2 (S2-01) - 2018

The Group Oral Poster Presentation is a compulsory assessment task. Groups of 4 students will research an aspect of drug development and prepare and present a poster on the topic. Contributions of individuals within the group will be determined by peer/selfassessment and will be used to moderate the final mark awarded to individuals in the team. Students who do not contribute appropriately to the preparation and presentation of the poster will therefore be penalised .

12 PHA3042 Modern drug development - Semester 2 (S2-01) - 2018

Assessment tasks IMPORTANT: All assessment tasks must be attempted. Assessment title:Practical Coursework and In-class Activities Alignment with learning outcome(s): outcome(s):The practical coursework and in-class activities included in this unitare designed to develop and assess the following unit learning outcomes: 1. Discuss the steps involved in the drug discovery process, including sources of drugs, how targets are identified and screening processes that can be used to test for desired activity; 2. Discuss the steps involved in developing a commercial product from a potential drug candidate, including the relevant regulatory framework and marketing considerations; 3. Critically evaluate methodologies and data from experiments in the context of the drug development process; 4. Obtain, present and interpret data from pharmacological experiments relevant to the area of drug development; 6. Work both independently and as part of a team.

Details of task:  Pre-prac exercises can be accessed via Moodle (in the relevant Theme block). These exercises will involve a short video which must be watched before completing a set of quiz questions. The quiz can be attempted up to 3 times. Marks are awarded providing a score of at least 80% is achieved .

Practical worksheets: Guided practical worksheets, including graphical representation of results, will be completed after practicals 1, 2 and 3. Specific requirements for each practical worksheet will be available either in the Practical Guide or provided in post-practical information that will be uploaded to Moodle on the Friday afternoon of the practical week. Final Practical Report: This report will present, describe and interpret all data acquired in practicals 1-4. The report is to be prepared in the format of a scientific paper and include a summary, introduction, methods, results and discussion. Further details regarding the task will be provided in the practical session in Week 3. In-class Drugs & Advertising Exercise: This in-class exercise will be conducted following the associated lectures ( content from CA-3 & CA-4). The exercise will be performed under exam conditions in the practical class Total - 25%.

13 PHA3042 Modern drug development - Semester 2 (S2-01) - 2018

Task

Details

Due Date

Worth

Pre-practical Exercises

Practical 1 (0.5%) Practical 3 (0.5%)

Thu July 26 Thu Aug 16 *Qui...