Pharmacology Essay Titles PDF

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Pharmacology Essay Titles (old module)...

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Write an essay on pharmacogenetic polymorphisms and discuss their role in, and relevance to, drug efficacy and safety. Write an essay on pharmacogenetic polymorphisms and discuss their role in, and relevance to, drug efficacy and safety.

Discuss histamine and its receptors as pharmacological targets in the treatment of allergy. Discuss histamine and its receptors as pharmacological targets in the treatment of allergy.

Give an account of the successive generations of acute anti-migraine drugs, how they were developed, their principle side effects, and whether they provided an improvement in the management of migraine. Give an account of the successive generations of acute anti-migraine drugs, how they were developed, their main side effects, and whether they provided an improvement (i.e., increased efficacy and/or fewer side-effects) in the management of migraine.

Give two examples of drugs targeting protein-protein interactions and discuss their pharmacological profile and mechanisms of action. Give two examples of drugs targeting protein-protein interactions and discuss their pharmacological profile and mechanisms of action. Give two examples of drugs targeting protein-protein interactions and discuss their pharmacological profile and mechanisms of action.

Discuss (providing representative examples of therapeutic drugs) the various ways that antihypertensive drugs can affect the renin-angiotensin system and its downstream target. Discuss (providing representative examples of therapeutic drugs) the various ways that antihypertensive drugs can affect the renin-angiotensin system and its downstream target.

Discuss the role of carriers and transporters in monoamine-mediated synaptic transmission, and provide examples of how they can be targeted to affect neurotransmission. Discuss the role of carriers and transporters in synaptic transmission, and provide examples of how they can be targeted to affect neurotransmission.

Explain how autophagy serves an essential role in cell health and longevity, and describe three pharmacological approaches used to therapeutically modulate autophagy. Discuss the merits and limitations of animal models used in drug development. Describe examples of those used for (i) cancer (ii) depression and (iii) neurodegenerative diseases. Evaluate the use of DMARDs (Disease Modifying Anti-Rheumatoid Drugs) compared to biologic response modifiers for the treatment of auto-immune diseases.

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Discuss the mechanisms of action of at least four classes of cancer chemotherapeutic agents which focus on the cell cycle. Explain why and how the proteins p53 and Bcl-2 could each be targeted for therapeutic purposes. Give an account of the development and use of monoclonal antibodies as immunomodulators for autoimmune diseases. Discuss angiogenesis-based anti-cancer therapies that do and do not function by targeting Vascular Endothelial Growth Factor (VEGF). Discuss pharmacological strategies to suppress innate immune responses that are involved in auto-immune diseases

Write an essay on enzyme induction and discuss its role in, and relevance to, drug efficacy and safety. Provide examples of clinical situations where this might be of relevance. Write an essay on cytochrome P450 isoenzymes and discuss their role in, and relevance to, drug efficacy and safety. Write an essay on enzyme induction and discuss its role in, and relevance to, drug efficacy and safety. Write an essay on enzyme induction and discuss its role in, and relevance to, drug efficacy and safety.

Describe, with examples, the mechanisms by which toxic damage to the kidney may occur. Describe, with examples, the mechanisms by which toxic damage to the nervous system may occur. Describe, with examples, the mechanisms by which toxic damage to the nervous system may occur. Describe, with examples, the mechanisms by which toxic damage to the liver may occur. Within the context of drug toxicity, describe (with examples) how drugs may adversely affect reproduction. Describe, with examples, the mechanisms by which toxic damage to the liver may occur.

Evaluate the function and selectivity of non-steroidal anti-inflammatory drugs with respect to modulation of enzyme activity and therapeutic effect. Evaluate the function and selectivity of non-steroidal anti-inflammatory drugs with respect to modulation of enzyme activity and therapeutic effect. Evaluate the function and selectivity of non-steroidal anti-inflammatory drugs with respect to modulation of enzyme activity and therapeutic effect.

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Write an essay on the use of animal models in drug development, with special emphasis on drugs aimed at managing psychiatric or neurological disorders. Discuss the function of p53 in the human cell and clearly demonstrate why it has been called “the guardian of the genome”. Explain how the affinity of a compound for a receptor can be experimentally determined. In your answer, outline the reagent requirements, the methodology of the procedure and data analysis to determine (i) the affinity of binding and (ii) if there is any co-operativity in binding. Answer the following questions related to ligand binding studies: A library of more than 1000 compounds that may possess antagonistic activity against 5HT1B receptors has been generated. One of these compounds (“compound X”) can be radioactively labelled. Describe, in detail, the methods and principles used to determine all of the following: (a) the affinity of compound X for 5-HT1B receptors. (b) the change in density of the receptor in the brain of Huntington’s disease patient (knowing that this brain disorder is associated with the death of neurons expressing 5-HT1B receptors). (c) the affinities of the other compounds in the library for 5-HT1B receptors, considering only compound X can be radiolabelled. Describe and compare the mechanisms of homologous and heterologous G Protein-Coupled Receptor (GPCR) desensitization Give an account, with examples, of how the organic chemistry of dyes led to the development of various classes of therapeutic compounds widely used today....