PREP 7 Bentonite- Phar Cen PDF

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INTERNATIONAL SCHOOL OF ASIA AND THE PACIFIC- KALINGA COLLEGE OF PHARMACY

PREPARTION NO.7 TITLE OF EXPERIMENT: BENTONITE MAGMA, USP

I. OBJECTIVE: To prepare Bentonite Magma. II. MATERIALS:

Beaker

Burner

Watch glass

Digital Balance

Graduated-cylinder

Spatula

Funnel

Stirring rod

III. FORMULATION: based on this formulation prepare only 400mL

Bentonite…………………………………...50 g Purified Water.........................................qs To make 1000mL

IV. COMPOUNDING PROCEDURE:

1. Weigh/Measure the needed ingredients accurately. 2. Heat 800ml of purified water. 3. To the heated water, sprinkle upon it the bentonite in portions, allowing each portion to become thoroughly wetted without stirring. 4. Allow to stand with occasional stirring for 24 hours. 5. Stir until a uniform magma is obtained. 6. Add sufficient quantity of water and to make the product measure 1000ml and mix well. 7. Place in an appropriate container. 8. Label the container properly.

V. QUESTIONS FOR RESEARCH:

1. What are suspensions? 2. What are the different dosage forms under suspensions? 3. How are magmas prepared? 4. What is bentonite? VI. CALCULATIONS. SHOW SOLUTION ON HOW TO REDUCE THE FORMULATION. Prepare only 400mL

GROUP NAME: PHARCEN DATE PERFORMED: AUGUST 14, 2021 WRITTEN REPORT SCORE:

PRODUCT SCORE: ___ RESEARCH SCORE:

BENTONITE MAGMA, USP

A.

PRODUCT INFORMATION SHEET. Synonyms/ Latin Names

Therapeutic classification Indication

•Native Colloidal Hydrated Aluminum Silicate (NCHAS) •Magma Bentoniti (Latin name) •Mineral soap magma •Wilhinite Soap Clay Magma N/A •Bentonite magma is used to influence the stability of other pharmaceutical and cosmetic products. •application in the extemporaneous compounding of prescriptions

Description of the Finished Product

A preparation of 5% bentonite, a native colloidal hydrated aluminum silicate, in purified water.

Method(s) of Preparation Used

TWO METHODS TO PREPARE BENTONITE MAGMA ●Mechanically -First method is done using a blender -Bentonite should be directly added to water while blender is on. ●Simple hydration -The other method used is when by scattering the bentonite in different portions, upon adding a purified hot water, thus making every part wet without the need to stir, before adding another portion.

Storage Condition Amount of Product Prepared Calculations for Formula Adjustment

-Scattering *Mixture needs to stand 24 hours before stirring *Helps prevents air from being incorporated -Swelling Store in a cool dry place. Preserve in tight containers. 400 mL

TO FORMULATE 400 mL Bentonite Purified Water

50 g 1000 mL

Factor(F)= _Amount desired_ Amount of formula F= _400mL_ = 0.4 1000Ml

B.

PRODUCT FORMULATION SHEET

Solution conti’d: Bentonite Purified Water

50g 1000mL

×0.4 20 g to make 400mL

INGREDIENT

C.

Bentonite

USE IN THE FORMULA Active ingredient

Purified water

Solvent, dispersing medium

PHYSICAL DESCRIPTION Natural clay product that consists mainly of colloidal, hydrated aluminum silicate Gray appearance; Earthy taste Odorless, tasteless, transparent liquid that is colorless in small amount but exhibits a bluish tinge in large quantities.

LABELING INFORMATION (Attach Product Label)

COMPOSITIONS: Bentonite BENTONITE MAGMA magma…………..20g Purified USP 400mL water…………… 1000mL

Shake use.

well

before

Mfg. lic. No.:ljjjj/2021 Batch No.: 1670 Mfg. Date: August 2021 MRP. Rs 55 (inclusive of all taxes)

STORAGE: Store in a cool dry place

Keep out of reach of

Manufactured children by: PharCen

In case of accidental ingestion, seek professional assistance or contact a Poison Control center immediately

D. ANSWERS TO QUESTIONS FOR RESEARCH 1. What are suspensions?

• • •

Suspensions: Preparations containing finely divided drug particles (the suspensoid) dispersed somewhat uniformly in a vehicle in which the drug exhibits minimum solubility. Insoluble dispersed phase (solid) in a dispersion medium. The biphasic liquid dosage form of medicaments in which the finely divided solid particles.

2. What are the different dosage forms under suspensions? A. Oral suspensions -are liquid preparations containing one or more active ingredients suspended in a sweetened, flavoured, sometimes coloured, and usually, viscous vehicle intended for oral administration. B. Topical suspensions -are suspensions designed for dermatological, cosmetic and protective purposes. C. Parenteral suspension/ injectable suspensions -These are dispersed, heterogeneous systems containing insoluble drug particles which are resuspended or re dispersed in either aqueous or vegetable oil vehicles before administering to

a patient. Most parenteral suspensions are designed for intramuscular or subcutaneous administration. C. Rectal suspensions -are liquid preparations intended for rectal use. Formulation and quality considerations for rectal suspensions are similar to that of oral suspensions. E. Otic Suspension -These are liquid preparations containing micronized particles intended for instillation in the outer ear. Most otic suspensions are antibiotics, corticosteroids, or analgesics for the treatment of ear infection, inflammation, and pain. F. Ophthalmic suspensions -are sterile liquid preparations containing solid particles dispersed in a liquid vehicle intended for application to the eye. It is imperative that such suspensions contain the drug in a micronized form to prevent irritation and/or scratching of the cornea. 3. How are magmas prepared? •Magmas are aqueous suspensions of insoluble inorganic drugs. They differ from gels in that the suspended particles are larger. Magmas are thick and viscous, and so there is no necessity of suspending agents. •There are 3 methods: Fusion Method; Cold Method; Dispersion Method -FUSION METHOD: In this method various waxy materials employed as gellant in non-polar media. Drug was added when waxy materials melted by fusion. stirred slowly until uniform gel formed. -COLD METHOD: Water was cooled to 4-10ºc and placed it in mixing container. Gelling agent was slowly added and agitating until solution is complete. Maintained temperature below 10ºc. Drug was added in solution form slowly with gentle mixing. Immediately transfer to container & allow to warm to R.T where upon liquid becomes clear gel. -DISPERSION METHOD: Gelling agent was dispersed in water with stirring at 1200 rpm for 30 min. Drug was dissolved in non-aqueous solvent with preservative. This solution was added in above gel with continuous stirring. 4. What is bentonite? Bentonite •Clays that are frequently generated by altering volcanic ash, that consists of predominant smectite materials, that are montmorillonite • Insoluble in water, swells upon addition of water.

REFERENCES: https://www.slideshare.net/saifullahkhan37017/gels-and-magmas GELS AND MAGMAS https://www.slideshare.net/ravikumarpatil26/suspensions-71574079 SUSPENSIONS https://www.scribd.com/document/432374119/Preparation-21-Bentonite-Magma BENTONITE MAGMA

E. EVALUATION GROUP NAME BANG-I, GERALDINE CALLUENG, C. DALE DUMAGDAG, CRIZA JAVIER, AILYN

MENDOZA, J. KATE

TOLENTINO, SANDY

FUNCTION

SUBMITTED TO: ARCHIMEDES O. BAYQUEN, RPh, MPH Laboratory Instructor

GRADING Rubrics:

REMARKS

COMPLETED CALCULATIONS PART, ANSWERS TO QUESTIONS FOR RESEARCH ANSWERS TO QUESTIONS FOR COMPLETED RESEARCH, CALCULATIONS PART ANSWERS TO QUESTIONS FOR DID NOT PARTICIPATE OR DID NOT RESEARCH, CALCULATIONS PART DO HIS/ HER PART PRODUCT INFORMATION SHEET AND COMPLETED PRODUCT FORMULATION, ANSWERS TO QUESTIONS FOR RESEARCH, RESEARCHER COMPLETED LEADER/ COMPILER, PRODUCCT INFORMATION SHEET AND PRODUCT FORMULATION, LABELLING OF PRODUCT, QUALITY ASSURANCE, RESEARCHER DID NOT PARTICIPATE OR DID NOT ANSWERS TO QUESTIONS FOR RESEARCH, PRODUCT FORMULATION DO HIS/ HER PART SHEET

GROUP NAME COMPLETENESS AND ACCURACY OF DATA AND INFORMATION  PRODUCT INFORMATION SHEET- 10 POINTS  PRODUCT FORMULATION SHEET- 10 POINTS  LABELING INFORMATION- 15 POINTS  ANSWERS TO QUESTIONS- 20 POINTS QUALITY OF OUTPUT TIMELINESS OF SUBMISSION INDIVIDUAL CONTRIBUTION OF EACH STUDENT REFERENCES AT LEAST 3 CITATIONS TOTAL

SCORE 55 POINTS

15 POINTS 10 POINTS 15 POINTS 10 100 POINTS

REMARKS...