RBC Maturation Sequence PDF

Title	RBC Maturation Sequence
Author	Mica Sanchez
Course	Introduction to Medical Laboratory Technology
Institution	Pontifical and Royal University of Santo Tomas, The Catholic University of the Philippines
Pages	1
File Size	61 KB
File Type	PDF
Total Downloads	42
Total Views	130

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Summary

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Description

BASOPHILIC NORMOBLAST (PRORUBRICYTE) 6:1 N:C Chromatin- begins to condense; deep purple-red

POLYCHROMATIC NORMOBLAST (RUBRICYTE) 4:1 N:C No nucleoli are present

ORTHOCHROMATIC NORMOBLAST (METARUBRICYTE) 1:2 N:C

POLYCHROMATIC ERYTHROCYTE

ERYTHROCYTE

No nucleus

No nucleus

Ribosomes- dark blue Golgi complex- pale, unstained

Deeper, richer blue

Hemoglobinpink color Murky gray-blue (polychromatic)

Hb productionsalmon pink Residual ribosomes- slightly bluish hue

Salmon-shaped Irregularly shaped

Biconcave disc Central Pallor

DIVISION

Two (2) daughter cells

Two (2) daughter cells

No division

No division

No division

LOCATION (in healthy states) CELLULAR ACTIVITY

Bone Marrow

Bone Marrow

Last stage capable of mitosis Bone Marrow

Bone Marrow

BM for 1 day Peripheral Blood

PB

1. Hemoglobin production 2. Enzymes of iron uptake 3. Protoporphyrin synthesis 4. Globin producction

Hemoglobin production

Hemoglobin synthesis

1. Complete production of Hb 2. Endoribonuclease 3. Reticulocytes- new methylene blue

Oxygen delivery

>24 hrs.

>24 hrs.

Approx. 30 hrs.

3 Days 2 Days BM 1 Day PB

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RBC STAGE

PRONORMOBLAST (RUBRIBLAST)

NUCLEUS

8:1 N:C 1-2 nucleoli; purple

CYTOPLASM

LENGTH OF TIME IN THIS STAGE

1. Hb production 2. Vimentin 3. Nonmuscle myosin 4. Pyrenocyte 5. Bone Marrow Macrophages -> Phosphatidlyserine 6. Howell-Jolly bodies

Approx 48 hrs.

RBC MATURATION SEQUENCE...