Sample/practice exam, questions PDF

Title	Sample/practice exam, questions
Course	Medical And Applied Immunology
Institution	University of Melbourne
Pages	2
File Size	42.7 KB
File Type	PDF
Total Downloads	112
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MST-1 Medical and Applied Immunology Short Answer Questions (5 marks): Describe the evidence for the existence of tumour antigens and compare the different types of tumour antigens. If there is an immune response to tumours, explain how tumours are able to evade this? Briefly compare the different types of immunotherapy. Explain the advantages and disadvantages of antibody-based immunotherapy and immunisation with tumour cells / antigens. Describe the process of adoptive cell therapy. Compare the central tolerance mechanisms of B and T cells. Discuss the process of T cell tolerance, and explain why this is critical for controlling selfreactive B cells. Describe the use of Ipilimumab and Nivolumab as a combination therapy. Discuss the differences between AMR and acute allograft rejection. Outline the drugs involved in the immunosuppressive cocktail and the purpose of each of them in avoiding transplant rejection. Discuss the role of BAFF in autoimmunity. Discuss the role of TACI in autoimmunity. Outline how not enough cell death can cause autoimmunity. Using an example, describe antibody mediated autoimmunity. Explain the relevant mouse model for this autoimmune disease. Using an example, describe T cell driven autoimmunity. Explain the relevant mouse model for this autoimmune disease. Explain the interplay of factors that lead to susceptibility to autoimmunity. Outline the acute and chronic response in coeliac disease patients, upon exposure to gluten. Briefly describe the pathogenesis of coeliac disease. Outline the pathogenesis of Crohn’s disease.

Compare the homing and presence of lymphocytes in the two barrier tissues – the gut and skin. Describe the compartments of the skin, making specific reference to their roles in the immune system. Outline the mechanism of skin specific T cell migration. Discuss the role of tissue resident memory cells in the skin and outline how they contribute to the pathology of some diseases....