Sim 1 FA20 – Cell Transport Simulation Graphs PDF

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BIOL 260 – Human Physiology

PhysioEx 10.0

Exercise 1: Cell Transport Mechanisms and Permeability Instructions: Please use the data table that you have generated in answering the PhysioEx activities to fill-in the table and generate the appropriate graphs. A) Activity 1: Simulating Dialysis (Simple Diffusion) 1) Effects of increasing pore size on simple diffusion – 4 solutes (excel) 4 graphs: NaCl, urea, glucose, albumin Pore Size NaCl Urea Glucose Albumin 0.0 20 (MWCO) 0.0 ? 0.0 ? 0.0 50 (MWCO) 0.0150 0 ? 0.0 ? 0.0 100 (MWCO) 0.0150 ? ? 0.0 0.009 0 0?.0094 0.0040 0 4 200 (MWCO) 0.0150 ? Analysis: 1) é solute size à _____ diffusion rate B) Activity 2: Simulated Facilitated Diffusion 1) Effects of increasing glucose carriers on facilitated diffusion of glucose (excel) 2 graphs: NaCl, urea, glucose, albumin # carriers 2 mM 8 mM 0.0008 500 ? ? 0.0023 0.0010 700 ? ?0.0031 900 0.0012 0.0038 Analysis: 1) é # carriers à _____ glucose facilitated diffusion rate (slope change?) C) Activity 3: Simulating Osmotic Pressure 1) Effects of increasing pore size on osmotic rate – 3 solutes (excel) Osmosis Rate: Pore Size NaCl Glucose Alb+Gluc 0.0 20 (MWCO) ? 0.0 ? 0.0 50 (MWCO) 0.0167 0 ? 0.0 0.0 100 (MWCO) 0.0167 ? ? 0.0 0.0044 200 (MWCO) 0.0167 ? 0 Analysis: 1) é solute size à _____ osmotic rate D) Activity 4: Simulating Filtration 1) Effects of increasing pore size on filtration rate – 4 solutes (excel) 2) Effects of increasing pore size on filtration concentrate – 4 solutes (excel) D1) Filtration Rate Pore Size NaCl 20 (MWCO) 0 2.5 50 (MWCO) 100 (MWCO) 5 20 200 (MWCO) No Analysis

Urea 0 ? 0.0 5 20

Glucose 0 ? 0.0 0 20

Charcoal 0 ? 0.0 0 0.0

D2) Filtrate Concentrate Pore Size NaCl Urea Glucose 0.0 0.0 20 (MWCO) 0.0 4.81 0.0 50 (MWCO) 0.0 100 (MWCO) ?4.81 ? 4.74 ? 0.0 4.34 200 (MWCO) 4.81 4.74

Charcoal 0.0 0.0

? 0.0 0.0...