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Columbia University BIOLUN3005_001_2019_1 - NEUROBIO II: DEVPT & SYSTEMS

Spring 2019 Syllabus 2/14/2019

Lectures: Tu./Th. 10:10-11:25 Room: 501 Schermerhorn Hall. Auditors allowed after permission is granted. Course website: https://courseworks.columbia.edu/ Instructor: Rafael Yuste, [email protected] Office Hours: By appointment through email. Teaching Assistants: Jaena Han Michelle Stackmann Sebastian Rolotti < [email protected]> Leslie Sibener Jonathan Lovas Masters students section: Tristan Geiller REQUIREMENTS: This course is the "capstone" course for the Neurobiology and Behavior undergraduate major at Columbia University It is designed for advanced undergraduate and graduate students. Knowledge of Cellular Neuroscience (how an action potential is generated and how a synapse works) will be assumed. It is strongly recommended that students take BIOL UN3004 Neurobiology 1: Molecular and Cellular Neuroscience, or a similar course, before enrolling in BIOL UN3005. Students unsure about their backgrounds should check a representative syllabus of BIOL UN3004 in http://www.columbia.edu/cu/biology/courses/w3004/index.html and study independently chapters 1-8 of the textbook. TEXT (Required): Neuroscience: Purves et al, 2018, Oxford University Press, 6th edition. ISBN 9781605353807 https://global.oup.com/ushe/product/neuroscience-9781605353807?q=purves&lang=en&cc=us The text is available at the Columbia Bookstore and in also in Book Culture. Several copies should be on reserve at the NWC Science Library. Students are expected to read the corresponding chapters for each lecture. TESTS: This course has no final exam. Instead, three tests are given during class time. Each noncumulative test covers material discussed in class and primary research articles discussed in the recitations. Rescheduling of tests is only granted under exceptional circumstances, in cases of serious illness or personal crisis, and the student is required to present a letter from the undergraduate dean as well as other supporting evidence (such as doctor’s notes, etc.). Please note all test dates ASAP and make travel arrangements accordingly. RECITATIONS: During the weekly recitations, students will present and discuss papers from the primary literature posted on the course website: https://courseworks.columbia.edu/ Weekly attendance at the recitations is mandatory for a passing grade and active participation counts in the final grade. Recitations will take place on:

Mondays 9-10am, Fairchild 1000 (except 3/4 TBA), Michelle Stackmann

Tuesdays 9-10am, Fairchild 1000, Leslie Sibener Wednesdays 9-10am, Fairchild 1000, Sebastian Rolotti < [email protected]> Thursdays 9-10am, Fairchild 1000, Jonathan Lovas Fridays 9-10am, Fairchild 1000, Jaena Han UN5005 students: Tuesday 9AM Fairchild 601C; Tristan Geiller All students need to sign up for one recitation emailing the corresponding TA and are required to attend that recitation till the end of the semester. The final exam will incorporate material from the recitations. The first recitations will be January 28th-Feb 1st GRADING: Each test will contribute 30% towards the semester grade. Participation in the recitations is required for a passing grade and will determine the remaining 10%. LECTURE PLAN (Numbers correspond to chapters in textbook) Unit I. Neural Signaling 1-8. Introduction (Ch.1 and Appendix) and The Neuron (Ch. 2-8)

Jan 22nd

Unit IV. The Changing Brain: 22. Early Brain Development

Jan 24th

Recitation 1: Jan 28th-Feb 1st: 23. Construction of Neural Circuits

Jan 29th

24. Circuit Differentiation: Intrinsic Factors and Sex Differences

Jan 31st

Recitation 2: Feb 4th-8th: 25. Experience-Dependent Plasticity in the Developing Brain

Feb 5th

26. Repair and Regeneration in the Nervous System

Feb 7th

Recitation 3: Feb 11th-15th: Unit II. Sensation and Sensory Processing 9. The Somatosensory System: Touch and Proprioception

Feb 12th

9. The Somatosensory System: Touch and Proprioception

Feb 14th

No recitations Feb 18th-22nd: Text week 10. Pain

Feb 19th

FIRST TEST

Feb 21st

Recitation 4: Feb 25th- March 1st: 11. Vision: The Eye

Feb 26th

12. Central Visual Pathways

Feb 28th

Recitation 5: March 4th-8th: 13 The Auditory System

Mar 5th

15. The Chemical Senses

Mar 7h

Recitation 6: March 11th-15th: Unit III. Movement and Its Central Control 16. Lower Motor Neuron Circuits and Motor Control

Mar 12th

17. Upper Motor Neuron Control of the Brainstem and Spinal Cord

Mar 14th

SPRING BREAK

Mar 18th-22nd

No recitations March 25th- 29th: Test week SECOND TEST

March 26th

18 and 19. Modulation of Movement by the Basal Ganglia and Cerebellum

Mar 28th

Recitation 7: April 1st-5th: 20 and 21. Eye Movements and the Visceral Motor System

April 2nd

Unit V. Complex Brain Functions and Cognitive Neuroscience 27. Cognitive Functions and the Organization of the Cerebral Cortex

April 4th

Recitation 8: April 8th-12th: 28. Cortical States

April 9th

29. Attention

April 11th

Recitation 9: April 15th-19th: 30. Memory

April 16th

31. Emotion

April 18th

Recitation 10: April 22nd -26th: 32. Thinking, Planning, and Deciding

April 23rd

33. Speech and Language

April 25th

No Recitations: April 29th- May 3rd: Test week 34. Development and Evolution of Cognitive Functions

April 30th

THIRD TEST

May 2nd

Recitation papers: 1. Jan 28 - Feb 1 Dendritic spikes as a mechanism for cooperative long-term potentiation (Nature, 2002) https://www.nature.com/articles/nature00854 2. Feb 4 - 8 Neuronal activity is required for the development of specific cortical interneuron subtypes (Nature, 2011) https://www.nature.com/articles/nature09865 3. Feb 11 - 15 A critical period for enhanced synaptic plasticity in newly generated neurons of the adult brain (Neuron, 2007) https://www.sciencedirect.com/science/article/pii/S0896627307003340 4. Feb 25 - March 1 Long-term sensory deprivation prevents dendritic spine loss in primary somatosensory cortex (Nature, 2005) https://www.nature.com/articles/nature03715 5. March 4 - 8 The emergence of functional microcircuits in visual cortex (Nature, 2013) https://www.nature.com/articles/nature12015 6. March 11 - 15 Sweet and bitter taste in the brain of awake behaving animals (Nature, 2015) https://www.nature.com/articles/nature15763 7. April 1 - 5 Regulation of parkinsonian motor behaviors by optogenetic control of basal ganglia circuitry (Nature, 2010) https://www.nature.com/articles/nature09159

8. April 8 - 12 Microstructure of a spatial map in the entorhinal cortex (Nature, 2005) https://www.nature.com/articles/nature03721 9. April 15 - 19 Medial prefrontal activity during delay period contributes to learning of a working memory task (Science, 2014) http://science.sciencemag.org/content/346/6208/458.long 10. April 22- 26 Optogenetic stimulation of a hippocampal engram activates fear memory recall (Nature, 2012) https://www.nature.com/articles/nature11028...