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NRSG 510 Advanced Pathophysiology Syllabus...

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California State University, Long Beach College of Health and Human Services School of Nursing

Fall 2021 Advanced Pathophysiology for Advanced Practice Nursing Nursing 510 Section 1

Faculty Noushin Khoiny, MD, MPH

STUDENTS ARE RESPONSIBLE FOR REVIEWING AND KNOWING THE ENTIRE CONTENT OF THIS SYLLABUS

Notes:  The instructor reserves the right to make changes to the syllabus as needed during the course period. Any changes will be communicated to you in advance and posted on BeachBoard.  Additional or modified reading assignments will be posted on BeachBoard in advance.  Some lectures may be video recorded online in addition to or in lieu of class meetings.  Schedule is subject to change due to class need.  Please note that official university communication will be through csulb.edu email. Please do not use personal email accounts.

2 Fall 2021 Semester Syllabus California State University, Long Beach School of Nursing I.

General Information: A. B. C. D.

E. F. G. H.

Course Number: Nursing 510 Title: Advanced Pathophysiology for Advanced Practice Nursing Units: 3 semester units Prerequisites: Admission to the graduate nursing program and completion of upper division pathophysiology course, or consent of instructor. Course Classification: C-4 Faculty: Noushin Khoiny, MD, MPH Contact Information: E-mail: Phone: Office Hours: Tuesdays 3:00PM-5:00PM Thursdays 11:00AM-12:00PM

I. Office Location: J. Class Meetings: K. Class Location:

Other times may be arranged by appointment Online via Zoom Tuesdays 8:00AM-10:45AM Nursing 62

L. Syllabus Revised by: M. Date of Submission:

Noushin Khoiny, MD, MPH August 2021

II. Catalog Description: Advanced pathophysiology principles underlying disturbances of human functioning, homeostatic mechanisms, cellular disturbances and the effect of environmental disruptive events on organ and system functions occurring throughout the lifespan. Letter grade only (A-F). III. Student Learning Outcomes (SLO): Upon successful completion of the course the student will be able to: 1. Integrate knowledge of pathophysiological processes related to major organ system dysfunction across the lifespan. 2. Assimilate the knowledge gained of pathophysiologic processes and begin to correlate this with physical assessment of clients of all ages in health care settings. 3. As learning practitioners, begin to understand the approaches to differential diagnosis and basic concepts of treatment. 4. Demonstrate understanding of core pathological processes commonly seen in the primary care setting and indications for acute care interventions across the lifespan. 5. Analyze the sequence of interactive cellular and organ system processes that result in disturbed homeostasis. 6. Apply the specific pathophysiological concepts related to major organ system dysfunction. 7. Apply gained knowledge of pathophysiology with information to be sought during physical assessment of clients.

3 8. Correlate pathologies with multisystem changes often observed during patient assessment.

IV. Texts: Required Texts:

Supplemental Texts: Andreoli, TE, Benjamin, IJ, Griggs, RC., & Wing, EJ (2016). Cecil Essentials Of Medicine (Ninth Edition). Elsevier Saunders. Ganti, L., Lebowitz, D., Rosario, J., & Vera, A. (2020). Step-Up to USMLE Step 2 CK (5th Edition). Wolters Kluwer. Kumar, V., Abbas, A., Aster, J. (2020). Robbins and Cotran Pathologic Basis of Disease (Tenth Edition). Elsevier. Norris, T. & Tuan, R. (2020). Porth’s Essentials of Pathophysiology (Fifth Edition). Wolters Kluwer. Norris, T. (2019). Porth’s Pathophysiology Concepts of Altered Health States (Tenth edition). Wolters Kluwer.

Zeind, C., & Carvalho, M. (2018). Applied Therapeutics: The Clinical Use of Drugs (Eleventh Edition. Wolters Kluwer.

V. Topics to be covered A. Introduction 1. Review conceptual framework for study of pathological mechanisms 2. Introduction to genetic impact on pathological disorders in primary care

4 3. Genotype versus phenotype 4. Patterns of inheritance 5. Common chromosomal aberration conditions 6. Role of epigenetics and cancer B. Basic pathological concepts 1. Molecular basis of human disease 2. Altered cellular biology, cellular adaptation, and cell death 3. Concepts of immunology 4. Stress – adaptation to potential maladaptation C. Pathological processes in cellular shock 1. Failure of compensatory mechanisms 2. Cardiogenic shock 3. Septic Shock 4. Hypovolemic Shock 5. Loss of neurological compensatory mechanisms 6. Introduction to concepts of acute care D. Pulmonary disorders across the lifespan 1. Obstructive disorders a. Asthma b. Chronic obstructive pulmonary disease 2. Restrictive disorders 3. Infectious diseases of the lungs E. Cardiovascular diseases across the lifespan 1. Hypertension 2. Congestive heart failure 3. Peripheral vascular disease 4. Coronary artery disease 5. Atherosclerosis and lipid disorders F. Renal disorders across the lifespan 1. Acute kidney injury 2. Chronic kidney disease 3. Fluid and electrolyte disorders G. Endocrine disorders across the lifespan 1. Disorders of the hypothalamic-pituitary-adrenal axis 2. Hypothyroidism 3. Hyperthyroidism 4. Cushing’s syndrome 5. Addison’s disease 6. Diabetes a. Type I DM b. Type II DM c. Gestational diabetes H. Gastrointestinal disorders across the lifespan 1. Gastric disorders, including but not limited to ulcers 2. Disorders of the small and large bowel, including but not limited to ulcerative colitis, & Crohn’s disease 3. Disorders of the pancreas and liver 4. Primary care considerations in major gastric pathology I. Disorders of the central nervous system across the lifespan 1. Transient ischemic attacks 2. Cerebrovascular accidents

5 3. Seizure disorders 4. Dementias and other cognitive disorders 5. Immediate and long term care considerations 6. Vertigo J. Hematological disorders across the lifespan 1. Microcytic anemia 2. Megaloblastic anemia 3. Normocytic anemia 4. Sickle cell anemia 5. Clotting and bleeding disorders 6. Leukemias K. Rheumatological disorders across the lifespan 1. Osteoarthritis 2. Rheumatoid arthritis 3. Gout 4. Septic arthritis 5. Systemic lupus erythematosus L. Common Skin disorders across the lifespan 1. Cellulitis 2. Impetigo 3. Malignant melanoma 4. Atopic dermatitis 5. Contact dermatitis 6. Herpes zoster M. Women’s health disorders across the lifespan 1. Dysmenorrhea 2. Amenorrhea 3. Abnormal uterine bleeding 4. Polycystic ovary syndrome 5. Vaginitis N. Men’s health disorders across the lifespan 1. Varicocele 2. Hydrocele 3. Testicular Torsion 4. Epididymitis 5. Balanitis O. Sexually Transmitted Infections 1. Gonorrhea 2. Syphilis 3. Chancroid 4. Herpes 5. Chlamydia 6. Human Papillomavirus

VI. Methods of Presentation A. Lectures B. Case studies C. BeachBoard documents

6 VII. Quizzes (60% of the final grade): There are six quizzes in this course. Each quiz is worth 10% of the final grade and will cover material presented in the lectures and readings for the respective course sections. Grading for quizzes will be on a straight grade scale as listed below. 90-100% = A performance at the highest level showing sustained excellence. 80-89.99% = B performance at high level showing consistent and effective achievement. 70-79.99% = C performance at an adequate level meeting basic requirements. 60-69.99% = D performance is less than adequate meeting minimum course requirements. Below 60% = F performance in which minimal course requirements have not been met. : Quiz 1: Tuesday, September 14, 2021 (topics include material from weeks 1-2 of course) Quiz 2: Tuesday, September 28, 2021 (topics include material from weeks 3-4 of course) Quiz 3: Tuesday, October 12, 2021 (topics include material from weeks 5-6 of course) Quiz 4: Tuesday, October 26, 2021 (topics include material from weeks 7-8 of course) Quiz 5: Tuesday, November 9, 2021 (topics include material from weeks 9, 10, 12 of course) Quiz 6: Tuesday, December 7, 2021 (topics include material from weeks 13-15 of course) ): The competency assessment is worth 20% of the final grade and will be cumulative and cover material from the course and textbooks. This exam is administered by Barkley or its equivalent and is a competency assessment. Please see the School of Nursing Policy for Competency Assessment which I have posted for your review on BeachBoard. The grading criteria for the Barkley or its equivalent competency assessment is as follows: The Barkley or its equivalent competency assessment will count for 20% of the final course grade. The exam will be given at the beginning of the course and as the final exam/post-test. The preassessment exam is to be taken on Tuesday, September 7th. The post-assessment test will be taken during the final exam week. The end of the semester exam will count for 20% of the final grade and will be graded on the following grading scale. Proficiency Level >80 70 - 79 60 - 69 50 - 59...