Synaptic Transmission PDF

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Summary

Dr. Lisa McIlvried...

Description

Synapses ● Synapses are the functional connections between neurons ○ 1000 synapses per neuron 14 ○ 10 synapses per brain

Types of Synapses: Electrical ● Connexons in both membranes align, forming an intercellular channel with a pore in the middle, called gap junctions ● Cells share cytoplasm, no gate between them, anything can flow between

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Allow passive flow of current directly through gap junctions ○ Either direction, positive or negative, regardless of amplitude (action potential not necessary) ○ Extremely fast ( Autoreceptors ○ Inhibit neurotransmitter release 2+ ○ Affect Ca , snare complex 2. Postsynaptic --> Modulate postsynaptic potential ○ Affect ionotropic receptors, ion channels

Ending Neurotransmission: deactivation of neurotransmitters 1. Enzymatic breakdown in the synapse 2. Reuptake by neuron by transporter ○ Enzymatic breakdown ○ Recycling into vesicles 3. Uptake by glia ○ Enzymatic breakdown ○ Recycling of precursors...