Celecoxib (Cele BREX) PDF

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Summary

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Description

CLIENT MEDICATION FORM Trade & Generic Names

Pharmacokinetics (absorption, [onset, peak, duration], distribution, metabolism, excretion)

Celecoxib (CeleBREX)

After oral administration, celecoxib is rapidly absorbed and achieves peak serum concentration in approximately 3 h. It is extensively metabolized in the liver, with very little drug (< 3%) being eliminated unchanged. The major routes of excretion for celecoxib are feces and urine

Classification

Therapeutic class: NSAIDs Pharmacologic class: Cyclooxygenase-2 inhibitors Client Order (include dosage, route, & frequency) 200 mg, PO, BID

Recommended Dosage Range

Adults: 200 mg PO daily as a single dose or in two equally divided doses. IV medication administration flow rate & dilution N/A

Uses/Indications (individualize for client) To relive signs and symptoms of osteoarthritis

Route: PO; Onset: Unknown; Peak: 3 hours; Duration: Unknown; Half-life: 11 hours Side Effects Headache, dizziness, insomnia, HTN, peripheral edema, pharyngitis, sinusitis, abdominal pain, diarrhea, nausea, hyperchloremia, back pain, dyspnea, erythema multiforme, exfoliative dermatitis Contraindications Contraindicated in patients hypersensitive to drug, sulfonamides, aspirin, or other NSAIDs. The risk of heart attack or stroke can occur as early as the first weeks of NSAID use. Risk appears greater at higher doses. Use lowest effective dose for shortest duration possible. Drug Interactions (include IV compatibility/incompatibility) ACE inhibitors, Anticoagulants, antacids containing aluminum or magnesium, aspirin, corticosteroids, CYP2C9 inhibitors, Digoxin, Lithium, Loop and thiazide diuretics, vancomycin, Warfarin Antidote (include dosage, route, & frequency) N/A Nursing Implications (including client teaching)

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Mechanisms of Action Thought to inhibit prostaglandin synthesis, impeding cyclooxygenase-2, to produce anti-inflammatory, analgesic, and antipyretic effects.

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Patients allergic to or with a history of anaphylactic reactions to sulfonamides, aspirin, or other NSAIDs may be allergic to this drug. NSAIDs cause an increased risk of serious GI adverse events, including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal Watch for and immediately evaluate signs and symptoms of heart attack (chest pain, shortness of breath, trouble breathing) or stroke (weakness in one part or side of the body, slurred speech). Advise patient to immediately report rash, unexplained weight gain, or swelling. Advise patient to seek medical attention immediately if chest pain, shortness of breath or trouble breathing, weakness in one part or side of the body, or slurred speech occurs....