Chapter 8 Study Guide - Lecture notes 8 PDF

Preview

Summary

Download Chapter 8 Study Guide - Lecture notes 8 PDF

Description

Chapter 8 Study Guide (Development of T and B cells) 1. B Cell Development in the Bone marrow shares many features with T Cell Development  What are the major goals of lymphocyte development?  Discuss the ordered steps of receptor rearrangement in B and T cells  Draw parallels between the two cell types  What is the function of the pre-B-cell- receptor and pre- T-cell receptors?  Why do T cells develop in the thymus and B cells develop in the bone marrow? 2. Know the properties and distinguish the two kinds of T cells αβ and δγ 2. Know the pathway of development of T cells with respect to expression of CD4 and CD8.  Any known regulators of the process 3. What are the possible fates of the T cell in the thymus? 4. What is the difference between a nude mouse and a SCID mouse in regard to T cell development? 5. Where does positive selection of T cells take place? When does positive selection occur? 6. Difference between positive and negative selection of T cells. 7. There are three main subsets of B cells : Follicular, Marginal zone and B-1. Compare and contrast their development and functions, cover at least 5 categories...