Chem 420 Spring 2019 Syllabus PDF

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Chem 420 Instrumental Methods of Chemical Characterization Spring 2019 Monday and Wednesday: 12:00 - 12:50 PM 1024 Chemistry Annex Instructor: Prof. Hee-Sun Han Office hours: Strictly by appointment, Monday, 5-6 PM, Location: TBA e-mail: [email protected] TAs and office hours: Alex W. Schrader Office hours: Mon 1-2 PM, Thurs 6-7 PM Office hour location: TBA e-mail: [email protected]

Sanja Pudar Office hours: Tues 4-5 PM, Fri 3-4 PM Office hour location: TBA e-mail: [email protected]

Any emails to TAs and instructor must have the subject starting as [Chem 420]; otherwise, it will not be answered. Instructor will not answer emails unless emails are about excused absence and request for office hour. Please email TAs for questions regarding homework, exams and other class-related matters. Emails will be answered within 24 hours. Textbook: Skoog, Holler, and Crouch, Principles of Instrumental Analysis, 7th Edition You will be required to read the designated chapters from this book throughout the semester Course website accessed via: http://compass2g.illinois.edu This website will be used to post class presentations, homework assignments, grades, surveys and additional multimedia used in the class. Basic knowledge of this platform and daily use of email for ensuring that class announcements are delivered is expected. Course Information: • Credit: 2 hours • Pre-requisites: Chem 440; or credit or concurrent registration in Chem 442; or consent of the instructor. • Covered materials: fundamental concepts and components of instruments, atomic and molecular spectroscopy, mass spectrometry, gas and liquid chromatography and materials characterization techniques Course objectives: Atoms and molecules are small and we cannot use our conventional human senses to directly “see” them in a way that is useful for most chemical analyses. Therefore, chemists have developed a vast array of instrumental methods for elucidating properties of chemicals. The overall objective of this course is to understand how instrumental methods operate so that you can better interpret the resulting information produced, and then use this information to solve chemical problems. Although they may seem to operate as such, scientific instruments are not simply black boxes and you can better understand how to use (or not) instrumentation by understanding what goes on “under the hood”. Chemical instrumentation affects your life every single day. Chemical instrumentation helps us explore and understand, search and learn, and decide whether or not something is true. Instrumental techniques facilitate chemical characterization over an incredibly broad range of

applications from the surface of a distant planet to the tiny crevice of a catalytic converter. Every day, cutting edge analytical tools allow researchers to peer inside single cells, count individual DNA molecules, or analyze small biochemical modifications to proteins implicated in human disease. Beyond exotic applications, instruments also play a key role in the analysis of food, drinking water, air, medicine, fuel, blood, and airline luggage – all substances or products we frequently encounter and rely on. This class is designed to provide an overview of instrumental methods of chemical analysis. We cannot see molecules directly, so we use instruments to illuminate atomic and molecular events and to answer questions such as “What is it?” and “How much?” and “Is it pure?”. An amazing number of diverse instruments exist commercially, each bringing inherent capabilities and shortcomings to the analysis of a given system or sample. This class aims to provide an understanding of what instruments can and cannot measure, how scientific measurements are made, why instruments are designed as they are, and how best to determine which instrument is most suited to address a given challenge. Rather than describe each technique in extraordinary detail, this course surveys some of the most common classical, modern, and emerging approaches to instrumental analysis of both simple and complex chemical and biomolecular systems. The course seeks to prepare students to analyze real-world challenges, select appropriate instrumental methods, interpret data appropriately, and seek greater detail if needed from method-specific literature to answer the chemical question at hand. Things to keep in mind This course will use i>clickers. You are responsible for bringing your controller to class and registering it in Compass 2g. I>clicker results will be registered for class attendance (a part of your grade). You are expected to always bring a pocket calculator, paper and pen to answer questions during class. Grading: Grading breakdown (total 400 pts) Hour exams (180 pts: 60 pts each) Final exam (100 pts) Problem sets (80 pts) Pop quizzes (40 pts) Attendance (after missing 4 classes, 2 points will be deducted from the total score per absence) I do not have a set grading scale, but rather will adjust to accurately reflect the performance of the students in the course. I do use plus and minus grades and will adjust grades to reflect natural breaks in the student distribution. In that case, the highest cluster will receive As, the next Bs, etc. with pluses and minuses assigned in a fair manner. Typically, about 1/3 of the course will get As (A+, A, A-), 1/3 will get Bs, 1/3 will get Cs. Grades lower than these usually reflect issues with effort and exam attendance. Problem sets are due at 12PM on the due date (before class) and will constitute 20% of the total course grade. Late submission (12:01 PM - the end of class) will be recorded late and will receive 80% of the score. If you know you will miss a class period when a problem set is due, you should turn in the assignment in advance of the absence. If you fail to turn in a problem set due to an approved excused absence, a grade commiserate with your average performance (relative to the rest of the class) on the other problem sets will be substituted at the end of the semester. Due to the limited number of TAs for this big class, we will do random grading for problem sets. Students need to complete all questions since we will not be revealing which questions will be graded. Each question on the problem sets will be worth the same amount, regardless of being graded for correctness. Therefore, if not all questions are completed, scaling factors will be applied (ex. If 4

out of 5 questions are completed, you will receive 80% of your original score). Problem sets will be randomly photo-copied as a record. Exams will be administered at the listed time period only and will constitute 70% of the total course grade. It is required to take every exam. The three hour-exams given during class will each be worth 15% of the total, and the comprehensive final worth 25% of the total. Make up exams will not be administered under any conditions, even in the case of an excused absence. If you miss an exam due to an approved excused absence, a grade commensurate with your average performance (relative to the rest of the class) on the other three exams will be substituted at the end of the semester. All exams will be closed book. No cheat sheet is allowed. I will provide necessary constants and equations. Exams will be will be randomly photo-copied as a record. Exams missed due to unexcused absences will result in a score of zero. If a conflict exists with a final exam period, the situation will be handled according to University policy and on an individual basis. If you miss the Final, an exam for which there is no substitute, you will receive an incomplete for the course. Pop quizzes. There will be random in-class pop quizzes, which constitute 10% of the total course grade. Pop quizzes will be simple questions that you can easily answer if you have been paying attention in class. They will also give me a quick feedback on how much you are following the lecture materials. Pop quizzes will be given at the end of the class. There are no make-up quizzes. Regrading: Hour exams may be submitted for a regrade up until the end of the class period following that in which the exam was returned. Restated, if you received your graded exam during Monday’s class, you have until the end of Wednesday’s class to submit the regrade. The exam should be submitted to Prof. Han with a cover sheet detailing the errors you felt were made. On this cover sheet, you will also need to officially state that you have made no changes to your exam answers. At the bottom, legibly provide your printed name and signature. DO NOT write on or modify the actual exam under any circumstances. If you do decide you would like your exam to be regraded, your entire exam will be regraded. Thus, your score may increase or decrease. Haggling over a few points is very likely not to your benefit. As a warning to those who may try to take advantage of this system, bear in mind that we randomly photocopy the graded exams. Your TAs will be crosschecking your returned exam against our copy to determine if cheating has occurred. Arithmetic errors will be fixed immediately without regrading the entire exam. Disability Services: Students with disabilities will be appropriately accommodated, and must inform me as soon as possible of their needs. Disability Resources and Educational Services is located at 1207 S. Oak St.; http://www.disability.illinois.edu; 217-333-1970; [email protected].

Course outline (subject to change): Date Jan 14 Jan 16 Jan 23

Homework

Jan 28 Jan 30 Feb 4 Feb 6 Feb 11

Assign PS 1 PS 1 Due

Feb 13 Feb 18 Feb 20 Feb 25 Feb 27 Mar 4 Mar 6 Mar 11 Mar 13 Mar 18 Mar 20 Mar 25 Mar 27 April 1 April 3 April 8 April 10 April 15 April 22 April 24

Assign PS 2 PS 2 Due

Assign PS 3 PS 3 Due Assign PS 4

Topic Course introduction and instruments in space Analytical signals and noise Basic statistics and calibration methods Analytical figures of merit and introduction to optical sources LASERS and properties of light Optical detection Catch up day/Exam review Hour Exam #1 Exam return and review, and Introduction to applied optical spectroscopy Atomic spectroscopies (AA, AF, AE) UV-visible absorption spectroscopy Fluorescence spectroscopy Infrared (IR) absorption and Raman spectroscopy Hour Exam #2 Exam return and review Introduction to separations Gas chromatography No class (Spring break) No class (Spring break) Liquid chromatography Capillary electrophoresis and its role in sequencing the human genome Mass spectrometry: Atomic and Molecular

Reading (Skoog) Chapter 1, Appendix 1, and Chapter 5 Chapter 6-7

Chapter 6 Chapters 8-10 Chapters 13-14 Chapter 15 Chapters 16-18

Chapter 26 Chapter 27

Chapters 28-29 Chapter 30

Chapters 11, 20

PS 4 Due

Assign PS 5

April 29 May 1

PS 5 Due

May 8

7-10 PM

Hour Exam #3 Exam return and review Materials characterization via surface spectroscopies : XPS, Auger, etc. Materials characterization via surface spectroscopies : AFM, STM, etc. Next generation DNA sequencing. Comprehensive Final Exam Location: TBD

Chapters 21 A-D, F Chapter 21G

Academic integrity, excused absences, the nature of the course, test accessories and safety: • You should always attend class – the PowerPoint presentations posted on Compass are a supplement, not a substitute, for attending class. The more you come to class, the more you will be prepared for the problem sets and exams. Please remember there will be random inclass pop quizzes. • Absences for problem sets and exams will only be considered excused if a note from the emergency Dean is provided within 1 week of the absence or your improved health (for multiday/absence maladies). Notes from McKinley are not acceptable to establish an excused absence. • Please, do not be disruptive during class. Instructors are responsible for maintaining a positive learning environment in the classroom, and whatever behavior that is found to interfere with or disrupt this environment will be taken seriously by the instructors and TAs. All students must behave according to the code of conduct and guarantee an inclusive environment for all peers and members of the University community http://oeoa.illinois.edu/campusconduct.html. Students whose behavior suggests the need for counseling or other assistance may be referred to their college office or University Counseling Services. Sexual harassment by any member of the University community, student, faculty, staff, administration, is prohibited according to the university policies that can be fully consulted at the following link: http://oeoa.illinois.edu/sexualharassment.html Even if you are not trying to learn, the person next to you or in the row behind is. Show respect for your own education and the learning environment of others. The instructor reserves the right to remove disruptive students from the classroom. • Buy the textbook. Yes, it is expensive, but you are expected to have access to the textbook material. Also, this text will be a valuable reference book in your future career as a chemical scientist. • All homework and exams must be written using an blue or black ink pen for any chance of additional credit during a re-grade. Also, in the process of regarding, additional points may be deducted if additional incorrect responses are identified. Any homework and exam written using pencils will receive 0. • Calculators are the only approved electronic devices allowed during exams and quizzes. Laptop computers or any other device with spreadsheet or data transmitting functions are expressly prohibited. • All assignments are expected to be representative of your own effort and understanding of the course material. Students are assumed and encouraged to work together on problem sets. However, each student must turn in their own work and NOT a copy, or substantially a copy, of another student’s work. • Any form of cheating and plagiarism on exams, problem sets, or quizzes will automatically result in a score of zero. Additionally, students may also be subject to additional action in accordance with Part 4 of the University’s Student Code. • Your safety. Please take a moment to consult the following information provided by the University’s Police Department regarding your preparedness for emergency situations: http://police.illinois.edu/dpsapp/wp-content/uploads/2017/08/syllabus-attachment.pdf and https://mediaspace.illinois.edu/media/t/1_bbti3ec5...