Concept map - How the immune system is connected to every process. PDF

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Summary

How the immune system is connected to every process....

Description

Innate Immunity

1st layer of defense

Physical barriers

includes

Mucosal membranes

includes

Chemical barriers

Cons of

Affinity maturation

Class switching

is ts

Antimicrobial proteins and peptides

Killing of infected host cells

Cellular innate responses

Complement system

Negative selection for T and B cells

Epithelial barrier

Th1 cells, Th2 cellsand Treg cells

Stimulates

Somatic hypermutation

Bone marrow

Produces

Inflammation Results in

includes

Occurs in

Initiates

Membrane Attack Complex

Phagocytes

Produces

Leads to

Natural Killer cells

PAMPS and PRRS

Hematopoiesis

includes

Macrophages Monocytes Neutrophils

Prod

u ces

Leads to

CD4 T cell activation

Primary lymphoid organs

Recognizes

Opsonization

CD4 T cell differentiatio

Perforin and granzymes

Inflammatory cytokine production

Occurs in

Antigen processing

CD8 T cell activation

Chemotaxis

Leads to

Antibodies

CD4 Th cells

CD8 Tc cells

n izes Recog ns antige d in nte prese

Secretes

Stimulates

BCR

antig e prese ns nted in

MHC class II

T cells Cell proliferation Cons of

Provides

is t s

Occurs in

Lymphocytes B cells

d H C if f e :p ren ep t tid es

s s is t Co n f o

Cell-mediated immunity

TCR

Leads to

Adaptive Immunity

Provides

MHC class I

Antigen M

Produces

Secondary lymphoid organs

Neutralization of pathogens or toxins

Phagocytosis Completely eliminates

Classical pathway connects to

Microbial infection

Provides

Thymus

Clonal selection

Occurs in

V(D)J recombination

Memory B and T cells

Produces

Humoral immunity

Immunological memory

Lymphocyte development

Protection against re-exposure

Killing of intracellular bacteria

Presented by

Leads to

Stimulates

Dendritic cells

APCs Killing of extracellular bacteria

Positive selection for T

B cell activation

Leads to

TI and TD B cell reponse...