Course Syllabus HEMA LEC AND LAB PDF

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COURSE SYLLABUS CLINICAL HEMATOLOGY 1

COLLEGE

COURSE DESCRIPTION MEDICAL LABORATORY SCIENCE

This course deals with the study of the development and diseases of the cellular elements of the blood. In this course, the fundamental concepts of DEPARTMENT MLS biology and chemistry are applied to the medical diagnosis and treatment of various disorders or diseases related to or manifested in the blood and COURSE CODE HEM 324 bone marrow. Emphasis is on laboratory diagnostic procedures which enables students to perform routine and special hematologic techniques important in diagnosing and prevention of disease with strict adherence to DESCRIPTIVE CLINICAL HEMATOLOGY principles of safety and quality assurance. TITLE 1 PREREQUISIT HIS 312, NSC E (S)

COURSE OUTCOMES(CO) After successful completion of Clinical Hematology, students already have: CO1.explain the facts and principles of hematological determinations which will aid the physicians in the diagnosis and treatment of blood diseases and other factors affecting blood indirectly CO2: identify microscopically the normal and abnormal blood cells CO3: demonstrate responsibility in handling blood specimen including examinations and reporting its results CO4: identify the importance of hematological tests to patient diseases CO5: apply the concept of quality assurance in hematology.

WEE K

UNIT OUTCOMES (UO)

COURSE CONTENT

I. University Mission-Vision and Core Values

1

1. Review precisely the University and College Mission-Vision, Core Values and Objectives and Grading System. 2. Explain the basic principles in Clinical Hematology correctly.

II. College Mission-Vision and Objectives III. Orientation to the course IV. Introduction to Clinical Hematology 1. Overview of Clinical Hematology

1. Enumerate hematological method of examination accurately. 2

2. Explain the quality assurance program for clinical hematology correctly

I. Basic Hematological Methods of Examination II. Quality Assurance Program III. Collection of Blood Specimen 1. Venipuncture

3. Differentiate methods of blood collection correctly.

3

2. Skin Puncture

1. Define hematopoiesis correctly.

I. Hematopoiesis

2. Enumerate the stages involved in hematopoiesis accordingly.

A. Stages of Hematopoiesis

3. Explain the types and roles of Bone Marrow in hematopoiesis accurately. 4. List other hematopoietic tissues necessary for cell production correctly. 5. Enumerate the important growth factors in the production of cells accordingly.

B. Bone Marrow Microenvironment C. Hematopoietic Tissues D. Growth Factors E. Stem Cell Theory

6. Discuss the concept of Stem Cell Theory correctly. Lineage Specific Hematopoiesis 1. Describe the specific morphological characteristics of lineage specific hematopoiesis correctly.

B. Granulopoiesis C. Lymphopoiesis

4 2. Differentiate the specific morphological characteristics of lineage specific hematopoiesis properly.

D. Monopoiesis E. Megakaryopoiesis

1.Describe the structural components of red blood cell correctly.

Red Blood Cell

2. Explain the different red blood cells metabolic pathways accurately.

A.

Structure

B.

Metabolism

C.

Destruction

D.

Function

5 3. Differentiate Intravascular lysis from Extravascular lysis accordingly. 4. Discuss the functions of red blood cell accurately.

6

A. Erythropoiesis

Preliminary Examination Hemoglobin 1. Describe the structure of hemoglobin accurately. 2. Explain the biosynthesis of hemoglobin properly.

7

8

A. Structure

B. Biosynthesis 3. Discuss the regulatory mechanism and functions of hemoglobin correctly. C. Regulation 4. Enumerate the different derivatives of hemoglobin accordingly.

D. Functions

1. Enumerate and describe the different red blood

RBC Abnormalities

E. Derivatives

cell abnormalities according to size, shape, hemoglobin content, inclusion bodies and associated diseases accordingly.

A.

2. Describe the different red blood cell B. abnormalities according to size, shape, hemoglobin C. content, inclusion bodies and associated diseases correctly. D. 3. Discuss correctly the manner of reporting of red E. blood cell abnormalities.

Anisocytosis Poikilocytosis Aniscochromia Inclusion Bodies Reporting of abnormalities

White Blood Cells 1. Describe the development and circulating kinetics of white blood cells (Circulation and Margination) correctly.

9

10

A. Development of White Blood Cells

2. Enumerate the different the types of white blood B. Circulating Kinetics of cells correctly. White Blood Cells 3. Discuss the functions of white blood cells C. Functions of White Blood accurately. Cells 4. Describe the different white blood cell D. Morphologic anomalies of abnormalities. White Blood Cells (Neutrophilic, Lymphocytic, Monocytic) correctly.

1. Explain the principles and procedures involved in the performance of complete blood count accurately. 2. Explain the uses and importance of complete blood count accordingly. 3. Describe the uses and importance of peripheral blood smear examination appropriately.

Laboratory Evaluation in Hematology

A.

Complete Blood Count

a.

Manual cell count

b.

Hemoglobin

c.

Hematocrit

d.

Blood indices

e.

Differential count

B.

1. Explain the principles and procedures involved in the performance of other special hematologic tests correctly.

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Peripheral Blood Smear

Laboratory Evaluation in Hematology

2. Explain the uses and importance of other special hematologic tests appropriately. A. Other special Hematologic 2. Explain the principles involved in automation in Tests hematology properly. B. Principles of Automation 3. Identify factors that affect automated routine hematologic tests accordingly.

12

Midterm Examination I. Red Blood Cell Disorders 1. Describe the pathophysiologic process of Anemia correctly. Anemia

13

2. Explain the types of Microcytic-Hypochromic anemia accordingly.

A.

3. Explain the types of Macrocytic Anemia accordingly.

B. Microcytic-Hypochromic Anemia C.

Introduction

Macrocytic Anemia

Red Blood Cell Disorders

14

15

1. Explain the types of Normocytic-Normochromic Anemia Anemia accordingly. A. Normocytic-Normochromic 2. Describe properly the characteristics of Thalassemia and Hemoglobinopathies. B. Thalassemia and Hemoglobinopathies

1. Describe the pathophysiologic processes of

Leukocyte Disorders

Leukocyte Disorders accurately. 2. Differentiate properly the types of quantitative and qualitative Leukocyte Disorders. 3. Explain properly the different classification of Leukemia.

1. Describe correctly the pathophysiologic processes of the different types of acute leukemia. 16

A.

Quantitative

B.

Qualitative

C.

Introduction to Leukemia

Leukocyte Disorders

2. Describe correctly the pathophysiologic processes of the different types of chronic leukemia.

A.

Acute Leukemias

B.

Chronic Leukemias

3. Explain correctly the pathophysiologic process and types of Lymphoma.

C.

Lymphoma

1. Explain the uses of cytochemistry properly in diagnosing hematological disorders.

A. Cytochemistry

17

B. Immunophenotyping 2. Discuss the principles and cell staining patterns in cytochemistry correctly.

18

Final Examination

TEXTBOOKS Keohane, E.M., Otto, C.N., Walenga, J.M., Rodak’s Hematology, 6thEdition: Clinical Principles and Applications, 2019 REFERENCES (BOOKS/ONLINE WEBSITES/JOURNALS) 1. Anderson S. and K. Poulsen. Anderson’s Atlas of Hematology. USA: Lippincott Williams and Wilkins, 2003. 2. Brown, Barbara. Hematology: Principles and Procedures 6th ed. Philadelphia: Lea and

Febiger, 1993. 3. Carr, Jaqueline and Bernadette Rodak. Clinical Hematology Atlas 3rd ed. Philadelphia: W.B. Saunders, 2008. 4. Garza, Diana and Kathleen Becan-McBride. Phlebotomy Handbook: Blood Collection Essentials 7th ed. USA: Prentice Hall, 2004. 5. Greer J., J. Foerster and J. Lukens. Wintrobe’s Clinical Hematology 11th ed. USA: Lippincott Williams and Wilkins, 2003. 6. Harmening D. Clinical Hematology and Fundamentals of Hemostasis. 5th ed. USA: F.A. Davis Co., 2008. 7. Hoeltke, Lynn. Phlebotomy: Principles and Procedures. USA: Delmar Learning, 2006. 8. Hoffbrand V., P. Moss and J. Pettit. Essential Haematology 5th ed. USA: Wiley-Blackwell, 2006. 9. Hoffman R. et.al. Hematology: Basic Principles and Practice 4th ed. USA: Churchill Livingstone, 2004. 10. McClatchey, Kenneth. Clinical Laboratory Medicine 2nd ed. USA: Lippincott Williams and Wilkins, 2002. 11. Mckenzie, Shirley, Clinical Laboratory Hematology. USA: Prentice Hall, 2006. 12. Mcpherson, Richard A. and Matthew R. Pincus. Henry’s Clinical Diagnosis and Management by Laboratory Methods 21st ed. Philadelphia: Elsevier Inc., 2007. 13. Reddi, V., M. Marques and G. Fristma. Quick Guide to Hematology Testing. USA: AACC Press, 2007. 14. Schmaier A. and L. Petruzelli. Hematology for the Medical Student. USA: Lippincott Williams and Wilkins, 2003. 15. Scott M., A. Gronowski and C. Eby. Tietz’s Applied Laboratory Medicine 2nd ed. USA: Wiley-Liss, 2007. 16. Steininger, Cheryl et al. Clinical Hematology: Principles, Procedures and Correlations. Philadelphia: J.B. Lippincot, 1992. 17. Theml, H. Color Atlas of Hematology: Practical, Microscopic and Clinical Diagnosis 2nd ed. USA: Thieme, 2004. 18. Turgeon, Mary Louise. Clinical Hematology: Theory and Procedures 4th ed. USA: Lippincott Williams and Wilkins, 2004. Electronic References: 1. http://wps.prenhall.com/chet_mckenzie_clinicallab.

2. http://www.bloodline.net/ 3. http://www.emedicine.com/med/topic132.htm 4. http://www.hematologyatlas.com/ 5. http://www.wadsworth.org/chemheme/heme/cytoheme/cyto35mm.htm...