Drugs on line quiz 1-3 PDF

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Drugs On Line quizzes

1. The sites sometimes used to store drugs taken into the body include: bone and fat 2. A drug-mediated response will be more intense if more receptors are occupied by the drug 3. Many adverse drug reactions are dose related. False 4. Some drugs increase the metabolism of other drugs by inducing synthesis of enzymes in the: Liver 5. A drug interaction that has an inhibitory effect: reduces therapeutic effects or adverse effects 6. The action of competitive antagonists will not be affected by increasing the concentration of the agonist. False 7. Which statement below best describes the term 'drug interaction'? One drug may increase or reduce the effect of another drug the client is taking 8. Adverse drug reactions may be genetically predisposed. True 9. Most drugs are metabolised by which organ? Liver 9. Adverse drug reactions are always unpredictable effects. False 10. In general, responses to orally administered drugs are less variable than responses to intravenously administered drugs. True

11. Drug excretion may occur at all sites EXCEPT: Hairs 12. When a drug has high selectivity it is likely to have/be: Less adverse effects 13.Virtually every tissue in the body is capable of drug biotransformation (drug metabolism). True 15. If the half-life of drug X is 4 hours and the initial concentration is 100mg/mL what will the concentration be at 6 hours? 37.5mg/mL 16. Allergic drug reactions occur more commonly: after more than one dose of the drug is given 17. Drugs are given by intravenous injection because they: Have 100% bioavailability 18. The rationale for sugar-coating capsules is to: Improve the palatability of the drug 19. When a receptor has prolonged exposure to an antagonist, it undergoes a process known as: up-regulation 20. The MOST important characteristics of a drug are effectiveness, safety and selectivity 21. A drug with high hepatic clearance will always have high renal clearance: False 22. Virtually every tissue in the body is capable of drug biotransformation (drug metabolism). True 23. A side effect of a drug is: a secondary drug response, not the primary reason for giving that drug

24. The site of dispersal of an enteric-coated tablet is: In the small intestine 25. The therapeutic range of a drug will elicit Therapeutic effects 26. Drug metabolism can be affected by all of the following EXCEPT: skin colour 27. All of the following statements about drug interactions are true EXCEPT: Drug interactions are always undesirable. 28. Non- prescription drugs are known as Over the counter (OTC) 29. A drug may cause all of the following EXCEPT: completely change the function of a cell 30. Drug-drug interactions can result in decreased adverse effects True 31. Because antagonist drugs do not activate receptors, these agents are of little therapeutic value. False 32. The therapeutic index of a specific drug is a measure of: Safety 33. When a drug has high selectivity it is likely to have/be: Less adverse effects 34. Plasma concentration of a drug is influenced by: Drug absorption and drug excretion 35. The prolonged exposure to agonists often results in receptor Down-regulation 36. Most drugs are metabolised by which organ ?

Liver 37. Target(s) for drug action include: Enzymes, ion channels and receptors 38. An ideal drug should be all of the following EXCEPT Expensive 39. Metabolism and excretion are processes involved in drug elimination True 40. Infants tend to be less sensitive to drug response False 41. The kidneys excrete most metabolites of drugs from the body True 42. Drug tolerance occurs as it becomes necessary to increase the dosage of the drug to produce the required effect. True 43. Following drug biotransformation lipid-soluble compounds may be excreted by the kidneys True 44. An antagonist is a drug that mimics the actions of natural substance (endogenous ligand) receptors False 45. A drug that is lipid-soluble passes rapidly through a cell membrane. True 46. Drugs are given by intravenous injection because they: Have 100% bioavailability 47. The rate of drug absorption is influenced by all of the following factors EXCEPT: Body weight of an individual 48. Targets for drug action include:

Enzymes, ion channels and receptors 49. A drug that binds to a receptor and stimulates it, leading to a response is called: Agonists 50. If the half-life of drug X is 4 hrs and the initial concentration is 100mg/ML what will the concentration be at 6 hrs? 37.5mg/mL 51. Drug metabolism can be affected by all of the following EXCEPT: Skin colour 52. A drug-mediated response will be more intense if: More receptors are occupied by the drug 53. In general, drug metabolism renders the drug: Less biologically active 54. All of the following statements about drug interactions are true EXCEPT: Drug interactions are always undesirable 55. A drug may cause all of the following EXCEPT: Completely change the function of a cell 56. Some drugs increase the metabolism of other drugs by inducing synthesis of enzymes in the: No answer 57. Most drugs are metabolised by which organ? Liver 58. A drug interaction that is _____ results in an increased drug effect. Potentiative 59. The dosing interval of a drug will be affected by which of the following: Half-life 60. A fall in a clients serum albumin will result in the:

Unbound drug increasing 61. Ventolin is administered to treat asthma, the drug can be administered via a puffer or aerosol spray. The drug is given this way because To minimuse undesired systemic effects 62. An aspirin may be enteric-coated to: Prevent irritation to the gastric mucosa 63. The rationale behind the use of sustained-release capsules is to: Provide a gradual but continuous release of the drug 64. The route used to be administer suppositories is usually: Rectally 65. The route most commonly used to administer a drug is: Oral 66. The sire of dispersal of an enteric-coated tablet is: In the small intestine 67. A barrier to transdermal drug delivery is the Stratum corneum 68. An oral form of medication where the drug enters circulation prior to being processed by the liver Sublingual wafer 69. The rationale for sugar coating capsules is to: Improve the palatability of the drug 70. Drugs that have little or no structural specificity with receptor sites are incapable of eliciting a response False 71. Bioavailability is the rate and extent to which an active drug is absorbed and becomes available: At the site of the action

72. Water soluble drugs readily cross capillary membranes once they have been absorbed. False 73. Most drugs are metabolised in the: Liver 74. Drugs administered via the gastro-intestinal route are called parenteral. False 75. Toxic drug concentration occurs: When plasma drug level is high 76. All of the following statements about drug interactions are true EXCEPT: Drug interactions are always undesirable 77. In general, drug biotransformation renders the drug: Less biologically active and easier to excrete 78. Bioavailability describes the proportion of administered drug reaching the systemic circulation. True 79. Pharmacogenomics is the study of an individuals genetic make-up in order to predict a response to a drug True 80. A potent drug: Both (a) and (b) are correct – don’t have the answer 81. Drugs administered into muscles cannot be absorbed. False 82. The study of drugs in humans is known as__________. Clinical pharmacology 83. The intensity of the response to a drug is determined predominantly by the: Concentration of a drug at its sites of action

84. An allergic response from an adverse drug reaction may be life threatening. True 85. Elderly individuals tend to be less sensitive to drug response. False 86. The metabolic process involved in drug biotransformation tend to: Increase renal excretion of the drug 87. Drugs given directly into the fatty layers beneath the skin are known as Subcutaneous injections 88. Parenteral drug administration elicits a fast response, which of the following is an example of parenteral administration? Intramuscular injection 89. The process of a drug moving from the site of administration to the bloodstream is called: Absorption 90. High use of “speed” leads to Psychotic episodes 91. The most pure form of methamphetamine is Ice 92. When a person has the desire to re-experience the effects of a substance, the person has developed: Dependence 93. The property that enhanced the effects for inhalants is their potential to Vaporise 94. A resumption of drug-seeking or drug-taking behaviour after a period of abstinence is called Relapse 95. Tolerance very quickly develops with the use of Ice

96. Complications of opioid abuse include all of the following EXCEPT: Decreased chance of risk-taking behaviour 97. Rohypnol can induce Amnesia 98. The most common withdrawal symptom from methamphetamine is Depression 99. Addiction is a behaviour pattern which features: All of the above 100. Exampled of 2 sympathomimetic hallucinogenic drugs are MDMA and LSD 101. Consumption of opioid (narcotic) analgesics: All of the above 102. Speedball users may choose which drug to soften withdrawal? Rohypnol 103. Ecstasy achieves its effects by Increasing serotonin release 104. The following statements concerning ‘fantasy’ are correct EXCEPT: Fantasy is also known as ecstasy 105. All of the following classes of substances are prohibited by the World Anti-Doping code EXCEPT: Anorectics 106. All of the following are potential adverse effects associated with the consumption of beta-adrenergic blocking agents (antagonists) EXCEPT: Hypertension and bradycardia 107. Erythropoietin in sport is used to: Increase the body’s oxygen carrying capacity

108. Anabolic effects directly relate to: Growth and development in muscle mass 109. Side effects of stimulant use may be Both physical and psychological 110. According to the IOC, doping can be characterised as the: All of the above 111. Performance enhancing drugs, known as ergogenic aids, Reduce the workload of an athlete 112. An example of nutritional supplement promoted in sporting activities includes: Creatine 113. Which of the following stimulants was removed from the banned list in sport 2006? Caffeine 114. The use of beta blockers enhances performance in sports such as Show jumping 115. The term ‘anabolic’ refers the effect that testosterone produces in the body to Increase muscle mass 116. One potential adverse effect from diuretic use of hyperkalemia. This refers to: Increased levels of potassium 117. Hirsutism refers to Excessive growth of body hair 118. Physiological changes which may affect young athletes using growth hormone for sport enhancements include Early epiphyseal plate closure 119. Characteristics of anabolic steroid abusers include all of the following EXCEPT: High self esteem 120. The hormone responsible for stimulating the production of red blood cells:

Erythropoietin 121. Indications of diuretic abuse include All of the above 122. Testing for the detection of Human Growth Hormone is detected in the Blood 123. Beta-blockers can be used therapeutically for all of the following conditions EXCEPT: Emphysema 124. A synthetic growth hormone was originally developed in the 1980’s to treat Kidney disease 125. All the following statements concerning opioids are correct EXCEPT: Opioids act by blocking dopamine and serotonin uptake transporters 126. GHB is often used at dance parties as an alternative to Ecstasy 127. Crack is a/an Smokable cocaine 128. The resin from the Cannabis sativa plant is known as Hashish 129. Males are more likely to use drugs for Recognition by peers 130. The harmful use of illicit drugs contribute to increased morbidity through: All of the above 131. Females are more likely to use drugs for Therapy 132. The property that enhances the effects of inhalants is their potential to Vaporise

133. Selective serotonin reuptake inhibitors (SSRIs): Affect the presynaptic neuron 134. Which of the following is a noradrenergic agent? Phentermine (Duromine) 135. Tricyclic antidepressants (TCAs): Block re-uptake of serotonin 136. Which of the following agents is MOST effective in alleviating anxiety disorder with or without depression? Venlafaxine (Efexor) 137. Commonly known side effects of the antidepressant Moclobemide: Insomnia and dizziness 138. Most antidepressants work by: Blocking neurotransmitter reuptake 139. Eating yeast-rich foods may cause a hypertensive emergency when taking: Monoamine oxidase inhibitors (MAOIs) 140. Risk factors for depression include: A history of physical and sexual abuse 141. The older monoamine oxidase inhibitors are likely to interact dangerously with all of the following EXCEPT: Skim milk and tea 142. Anorectic drugs include: Fenfluramine (Pondimin) and phentermine (Duromine) 143. The mechanism of action of sibutramine is to: Inhibit both the reuptake of noradrenaline (norepinephrine) and serotonin in the brain 144. Which of the following type of agents slows gastric emptying? Pramlintide (Symlin)

145. Obese individuals are more prone to: Depression and blood clots 146. A body mass index (BMI) of 25-29.9kg/m2 is classified as: Overweight 147. A cannabinoid antagonist promotes weight loss by: Diminishing appetite 148. A neurotransmitter strongly implicated in appetite control is: Serotonin 149. Ephedrine causes weight loss by stimulating __________ receptors? Beta3-adrenergic 150. Orlistat (Xenical): Reduces fat absorption 151. Blockade of which one of the following types of receptors causes blurred vision in patients who are taking tricyclic antidepressants (TCAs)? Muscarinic receptors 152. Possible adverse effects of sibutramine (Reductil) include all of the following EXCEPT: Hyperphagia 153. One of these anti-obesity drugs is poorly absorbed when administered orally: Orlistat (Xenical) 154. Jemimah Freeman is a middle aged woman with obesity. Her problems started 5 years ago after the death of her partner. She initially tried a number of alternative therapies, including Traditional Chinese Medicine (TCM), to overcome depression, but eventually clinical depression was diagnosed and medical treatment was advised for both her obesity and her depression. If Jemimah was prescribed Axokine she could develop Drug resistance and possible allergic reaction 155. Jemimah Freeman is a middle aged woman with obesity. Her problems started 5 years ago after the death of her partner. She initially tried a number of alternative therapies, including Traditional Chinese Medicine (TCM), to overcome depression, but eventually

clinical depression was diagnosed and medical treatment was advised for both her obesity and her depression. Which of the following traditional therapies would be thought likely to benefit Jemimah in the early stages of her depression? St Johns wort 156. Jemimah Freeman is a middle aged woman with obesity. Her problems started 5 years ago after the death of her partner. She initially tried a number of alternative therapies, including Traditional Chinese Medicine (TCM), to overcome depression, but eventually clinical depression was diagnosed and medical treatment was advised for both her obesity and her depression. Which combination of factors makes Jemima likely to be predisposed to depression? Female, personal loss, hormonal profile 157. The elements of TCM are Water, fire, metal, wood and earth 158. TCM uses the eight principles to Assess symptoms and assist in the diagnosis of certain conditions 159. Approximately how many Australians use complementary medicines? 66% 160. The underlying philosophy of Traditional Chinese Medicine is A balance exists between all organ systems and functions 161. Alternative therapies include biologically based practices such as Herbal teas 162. Which are the most commonly used complementary medicines? Vitamins 163. In TCM the body part most useful for diagnosis of conditions is the Tongue 164. In TCM, which element relates to conditions of the small intestine? Fire

165. Chinese medicines can contain different combinations of All of the above 166. Chinese herbs may combine up to 15 herbs for mutual Reinforcement for stronger effects 167. Written in approximately the 7th century BC, this is still a famous classic of Chinese medicine today. Yi Jing 168. Qi is the life force circulating through the body. Qi travels which system of pathways? Meridians 169. “Like cures like” is the principle of which complementary therapy? Homeopathy 170. Serial dilution is a process in homeopathy which Progressively weakens the therapeutic ingredient 171. In Chinese cosmology the compass directions assumed an individual faced south. When an Emperor faces South he is also said to? Receive the influence of heaven and yang 172. Homeopathy aims to cure through promoting Reintroduction of diluted original harmful substances 173. Appetite is stimulated by: Cannabinoids 174. The mechanism of action of phentermine (Duromine): Increases noradrenaline release from the presynaptic membrane 175. An adverse effect of caffeine is: Hypertension 176. Which of the following anti-obesity drugs are associated with an increased incidence of primary pulmonary hypertension? Dexenfluramine (Redux) and fenfluramine (Pondimin)

177. A decoction involves medicines delivered as Teas 178. A meridian in TCM is a Pathway of life forces and energy 179. Jemimah Freeman is a middle aged woman with obesity. Her problems started 5 years ago after the death of her partner. She initially tried a number of alternative therapies, including Traditional Chinese Medicine (TCM), to overcome depression, but eventually clinical depression was diagnosed and medical treatment was advised for both her obesity and her depression. Jemimah would initially have suffered from Reactive depression 180. Jemimah Freeman is a middle aged woman with obesity. Her problems started 5 years ago after the death of her partner. She initially tried a number of alternative therapies, including Traditional Chinese Medicine (TCM), to overcome depression, but eventually clinical depression was diagnosed and medical treatment was advised for both her obesity and her depression. If Jemimah chooses to support her drug therapy with a complementary therapy, which type would be best advised? A/an Mind-body practice 181. Drug metabolising enzymes found in which medicine reduces the plasma concentration of certain drugs? Hypericum perforatum (St John’s Wort) 182. Selective serotonin reuptake inhibitors (SRRIs) and serotonin-noradrenaline reuptake inhibitors (SNRIs) are: No more effective than TCAs or MAOIs...