immunity blood cell textbook notes PDF

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textbook notes - descriptions of immunity blood cell...

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B Leukocytes Participate in Humoral immunity. T Leukocytes Participate in cell-mediated immunity Null Cells Lack surface markers, most are natural killer cells Natural Killer Cells Nonspecific immune response: Generally attacks & destroys foreign cells. Specific immune response: Act in response to IL-2 released by T cells. Subtypes of T cells Memory T cells Cytotoxic T cells Helper T cells Suppressor T cells Subtypes of B cells Memory Cells Plasma Cells Interleukin-1 When released by macrophages, causes fever. Causes B cells to proliferate & differentiate When released by B cells, causes T cells to proliferate & differentiate. Interleukin-10 Inhibits cytokine production by macrophages. Negative feedback of inflammation. Interferon-gamma Does anything & everything to "interfere" with evil plans: Makes cells resistant to viruses Inhibits cancer cell proliferation Stimulates phagocytosis Stimulates Cytotoxic T-cells & NK cells Remembering: Interferon-gamma released by infected cells. Interferon-gamma targets infected cells or cells actively involved in immune response. Interleukin-2 Involved in specific immune response. Essential for B cell differentiation into memory cells Promotes B cell differentiation into plasma cells Promotes Helper & Cytotoxic T-cells Activates NK cells in specific immune response. Hot T-bone stEAK (IL-1 - 6 actions)

IL-1: fever (hot) IL-2: Stimulates T cells IL-3: stimulates proliferation/differentiation in bone marrow (Like GM-CSF) IL-4: stimulates IgE production IL-5: stimulates IgA production IL-6: stimulates "aKute" (Acute)-phase proteins, Pro-inflammatory. Interleukins secreted by Helper T-cells IL-2 IL-3 IL-4 IL-5 IL-6 IL-10 GM-CSF Interferon-Gamma Interleukin-4 Targets B cells Helper T cells Macrophages (Increases number of class II MHC molecules, enhances phagocytois) Mast Cells Interleukin-5 Targets B cells Hematopoietic stem cells (increases eosinophils) Eosinophils Release toxic substances in granules to defend against parasites. Can also act as phagocytes. GM-CSF Granulocyte-monocyte colony-stimulating factor Stimulates Leukocyte differentiation & proliferation in bone marrow....