Med Card Bosentan PDF

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Med Card Bosentan...

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INSTRUCTIONS: 1. For each chapter that teaches about medications, fill in the following table regarding the chosen meds. CLASS: endothelin receptor GENERIC NAME: Bosentan TRADE NAMES: Tracleer antagonists MOA: Antagonizes the effects of the neurohormone endothelin by binding to its receptor sites in endothelium and vascular smooth muscle. INDICATIONS: 1. Pulmonary arterial hypertension (PAH) (WHO Group 1). 2. Idiopathic or congenital PAH. CONTRAINDICATIONS/PRECAUTIONS: Contraindicated in: Hypersensitivity Concurrent use of cyclosporine or glyburide Concurrent use with a CYP2C9 inhibitor and a strong or moderate CYP3A4 inhibitor Moderate to severe liver impairment or patients with liver enzymes (>3x ULN) OB: Pregnancy (may cause fetal harm); Lactation: Lactation. Use Cautiously in: Rep: Women of reproductive potential Pedi: Children...