Pharmaceutical Calculations practice exam 1 PDF

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Examiner: Dr Jan Daly...

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A GPHC-APPROVED CALCULATOR IS PERMITTED FACULTY OF SCIENCE AND ENGINEERING SCHOOL OF PHARMACY FORMATIVE EXAMINATION PAPER ______________________________________________________________ Module Code : 5PY022 Examination title: Pharmaceutical Calculations Sitting: Formative paper 1 Date: December 2020 Year leader: Dr Ayman Antoun Reyad Examiner: Dr Jan Daly Time Allowed: 1 hour ______________________________________________________________ Instructions to candidates: This is a closed book examination. The assessment consists of 20 ‘fill in the box’ questions to be completed in 1 hour. Print your name and student number clearly in the space provided at the bottom of this page. Attempt ALL questions. The pass mark is determined by cut-scoring and there is no negative marking. Write your final answer in the ‘Answer’ section at the bottom of each question, using the pre-printed answer grid. Your final answer must be written in the answer grid using a pencil. If you wish to change an answer, rub out your first solution carefully, taking care not to smudge across the boxes, then re-write your answer clearly. The decimal point is already placed on the answer grid. When completing the answer grid use the pre-entered decimal point to guide you. For example if the answer is 118 tablets, fill in the answer as shown below. For whole numbers, do not enter zeros after the decimal point.

Decimal points are provided. If the answer contains a decimal point, use the decimal point that is pre-entered. For example if the answer to a question is 450.5 g, fill in the answer as shown below.

Do not use commas. For example if the answer is four hundred and thirty thousand units, write this as 430 000 as shown below.

However, if the answer is less than 1, then enter a ‘leading’ zero, e.g. write 0.15 mL as shown below

It is an examination requirement that you show a logical working out process to arrive at a computed answer. Accordingly, even where a submitted answer is correct, it will not be awarded a mark in the absence of a logical working out method with supporting numerical data. Read the questions carefully, and ensure that all answers are expressed in the units specified in the answer box

Student name: …………………………………………….

Student number: …………………………….. 1

A calculator is permitted. Write your final answer for each question clearly in the ‘Answer’ box Question 1 Disinfectant D is available as a 90%v/v stock solution. The local community hospital asks you to prepare 5.25 L of 0.06% v/v disinfectant solution for cleaning hard surfaces. How many mL(s) of the stock solution are required? Give your answer to 1 decimal place.

WORKING OUT

Answer:

mL(s)

Question 2 An injection is available as a 1 in 8000 solution. The dose for a child is 87.5 micrograms. How many mL(s) of injection will contain a child’s dose? Give your answer to 1 decimal place.

WORKING OUT

Answer:

mL(s)

Question 3 You receive a prescription for 200 mL of an oral solution containing sodium bicarbonate 2 mmol/5 mL, which you will prepare using a commercially-available solution of sodium bicarbonate 4.2%w/v. How many mL(s) of the 4.2%w/v solution would you need to prepare the prescription item? (Mr for sodium bicarbonate is 84).

WORKING OUT

Answer:

mL(s) 2

Question 4 A child, weighing 14.4 kg, is being treated in hospital for suspected pneumonia with benzylpenicillin at a dose of 200 mg/kg/day, given in divided doses every four hours. Single vials of benzylpenicillin contain 600 mg in 2 mL. How many mL(s) will provide one dose? Give your answer to 1 decimal place.

WORKING OUT

Answer:

mL(s)

Question 5 Mr J asks to buy cough linctus for himself, his mother, and his two children aged seven and ten; sufficient for five days. The dosage instructions are: adults, the elderly and children over 12 years – take two 5 mL spoonsful; children 6 -12 years – take one 5 mL spoonful. Repeat after 4 hours, but not more than 4 doses in 24 hours. If each bottle of linctus contains 250 mL, how many bottle(s) would you sell Mr J? s

WORKING OUT

Answer:

bottle(s)

3

Question 6 Antiseptic C is available as a 1 in 20 solution which is further diluted before use. How many mL(s) of this solution would you use to prepare 3.5 L of a 0.75% w/v solution for use as a skin cleanser?

WORKING OUT

Answer:

mL(s)

Question 7 You are required to supply eight suppositories each containing 500 mg of aminophylline, using theobroma oil as the suppository base, and a mould size of 4 g. You decide to prepare ten suppositories to allow for any wastage during preparation. How many gram(s) of the suppository base do you require? Give your answer to 2 decimal places. The displacement value for aminophylline in theobroma oil is 1.3

WORKING OUT

gram(s)

Answer:

4

Question 8 Keflex® capsules contain cefalexin monohydrate but the dose is expressed in terms of anhydrous cefalexin. How many milligram(s) of the monohydrate, equivalent to 500 mg of anhydrous cefalexin, does each capsule contain? Mr cefalexin monohydrate = 365, Mr anhydrous cefalexin = 347. Express your answer to the nearest whole number.

WORKING OUT

Answer:

mg

Question 9 A patient is prescribed ‘Hear-Clear’ ear drops for use in both ears to facilitate the removal of ear wax. The usage instructions are to ‘instil five drops per ear, twice daily, for ten days’. Assuming the dropper delivers 20 drops per mL and that a bottle of ‘Hear-Clear’ contains 8 mL, how many bottle(s) will you need to supply?

WORKING OUT

Answer:

bottle(s)

5

Question 10 A particular brand of an oral antibiotic powder for reconstitution has a displacement volume of 4.8 mL/g of antibiotic A. You are required to prepare 100 mL of reconstituted suspension, which contains 250 mg of antibiotic A in each 5 mL dose after reconstitution. How many mL(s) of water should be added to the powder in the container to produce a final volume of 100 mL?

WORKING OUT

Answer:

mL(s)

Question 11 Miss N has been prescribed drug V by her hospital consultant, to be reviewed in 3 weeks’ time. She requires 300 mg o.d. on days 1 and 2, then 300 mg b.d. on days 3, 4 and 5, followed by 300 mg t.d.s. thereafter. The hospital consultant requests 4 weeks supply in total. How many tablet(s) should be supplied if each tablet contains 150 mg of drug V?

WORKING OUT

Answer:

tablet(s)

6

Question 12 A 7-year-old boy, weighing 20 kg, has been admitted to hospital for emergency surgery. At the initiation of anaesthesia he is given an intravenous injection of fentanyl at a dose of 2 micrograms/kg, followed by a further dose of 1.25 micrograms/kg at a later stage in the operation. The fentanyl injection contains 0.1 mg/2 mL. How many mL(s) of fentanyl injection will he have received in total? Give your answer to 1 decimal place.

WORKING OUT

Answer:

mL(s)

Question 13 You receive a prescription from the skin clinic for 30 grams of 0.4% w/w hydrocortisone cream, to treat a baby with eczema. 1% w/w hydrocortisone cream is available in the pharmacy, which may be diluted with a suitable base. How many gram(s) of the diluent base are required to prepare this prescription?

WORKING OUT

Answer:

gram(s)

7

Question 14 How many micromole(s) of an active pharmaceutical ingredient are contained in 5 mL of solution, given that the Mr is 50 and the solution is 1 in 8,000? Give your answer to 1 decimal place

WORKING OUT

Answer:

micromoles

Question 15 How many mL(s) of water should be added to a 12.5 %w/v concentrated ‘stock’ solution of disinfectant to prepare 750 mL of a 0.25% w/v solution?

WORKING OUT

Answer:

mL(s)

8

Question 16 A doctor has prescribed 150 mL of a solution containing 30 mg/mL of drug R for Mr TR. The dispensary has solutions containing 4% w/v and 1% w/v of drug R available. How many of mL(s) of the 1% w/v solution should be mixed with an appropriate quantity of the 4% w/v strength to prepare 150 mL of a solution containing 30 mg/mL of drug R?

WORKING OUT

mL(s) of 1% w/v

Answer:

Question 17 A pharmaceutical product is available as bottles containing 50 mL of a 6 % w/v solution of the active pharmaceutical ingredient (API). Before first use the patient is instructed to add 30 mL of water to the bottle, mix well, and then use it as a skin cleanser. What is the concentration of API (in mg/mL) in the solution that the patient applies to their skin? Give your answer to 1 decimal place.

WORKING OUT

Answer:

mg/mL

9

Question 18 Drug K has a displacement volume of 0.08 mL/5 mg. You add 38 mL of water to a bottle containing drug K (as a powder for reconstitution) and this produces a final volume of 50 mL. How many milligram(s) of drug K does the bottle contain?

WORKING OUT

Answer:

mg

Question 19 Master J’s medication chart comes down from the paediatric ward with a take-home prescription for drug D at a dose of 20 micrograms/kg three times a day for 7 days. You contact the ward and are told that Master J, age 10, weighs 32 kg. Drug D is available as an oral solution containing 0.1 mg/mL. How many mL(s) of the oral liquid would you dispense to ensure sufficient for 7 days’ supply? Give your answer to the nearest whole mL.

WORKING OUT

Answer:

mL(s)

10

Question 20 A child is prescribed 600 micrograms of a potent diuretic as an oral dose. It is available in the hospital pharmacy as a solution containing 4 mg/mL. Following the hospital’s local policy you measure 5 mL of this solution and dilute it to 20 mL with water before sending the resulting solution to the paediatric ward. How many mL(s) of the diluted solution provides one dose for this child? Give your answer to 1 decimal place.

WORKING OUT

Answer:

mL(s)

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