Probenecid Medication PDF

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ACTIVE LEARNING TEMPLATE:

Medication

Loureiro STUDENT NAME Valerie _____________________________________ (Probalan) MEDICATION probenecid __________________________________________________________________________ REVIEW MODULE CHAPTERGOUT ___________ derivative CATEGORY CLASS Sulfonamide ______________________________________________________________________ PURPOSE OF MEDICATION

Expected Pharmacological Action Increases urinary excretion of uric acid and lowers serum acid level, which may prevent or resolve urate deposits, tophus formation, and joint changes. Eventually, incidence of acute gout attacks decreases. Probenecid also inhibits renal excretion of penicillins and some cephalosporins, thereby increasing their serum concentration and prolonging their duration of action.

Therapeutic Use To treat chronic gouty arthritis and hyperuricemia due to chronic gout.

Complications Dizziness, headache Sore gums Anorexia, nausea, vomiting Hematuria, renal calculi, renal colic, urinary frequency Costovertebral pain, joint pain, redness and swelling Facial flushing, pruritis, rash, urticaria

Contraindications/Precautions Age less than 2 years, blood dyscrasias, hypersensitivity to probenecid or its components, renal calculi (urate).

Interactions acyclovir: decreased renal tubular secretion of acyclovir allopurinol: additive antihyperuricemic effects heparin: increased and prolonged anticoagulant effect riboflavin: decreased GI absorption of riboflavin thiopental: prolonged thiopental effect alcohol use: increase in hyperuricemia, decreased probenecid effectiveness

Medication Administration Probenecid comes in a tablet to take by mouth. It usually is taken two times a day when prescribed for chronic gout or gouty arthritis and four times a day when prescribed with antibiotics to make them more effective.

Nursing Interventions Be aware that probenecid therapy should not start until acute gout attack has subsided. Use drug cautiously to patients with peptic ulcer disease. Closely monitor patients receiving intermittent therapy because they're more likely to develop allergic reactions. Check blood glucose level often in diabetic patient who takes a sulfonylurea because of the risk of drug interactions.

Client Education Evaluation of Medication Effectiveness

ACTIVE LEARNING TEMPLATES

Advise patient to take probenecid with meals to minimize GI distress. Encourage patient to increase fluid intake (up to 3 L daily) to help prevent renal calculus formation. Instruct patient to immediately notify HCP if they have signs of acute gout attack (joint pain, swelling, redness) Caution patient against taking salicylates while taking probenecid. Instead, advise acetaminophen to treat mild pain or fever....